177 results about "Polysorbate 20" patented technology

The present invention generally relates to the transdermal delivery of various compositions. In some aspects, the transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ibuprofen and/or an ibuprofen salt, a nitric oxide donor, and optionally, a hostile biophysical environment. In some cases, the composition may be stabilized using a stabilization polymer such as xanthan gum, KELTROL® BT and/or KELTROL® RD; propylene glycol; and a polysorbate surfactant such as Polysorbate 20, which unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.

The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising a phosphodiesterase type 5 inhibitor and/or a salt thereof, and optionally, a hostile biophysical environment and/or a nitric oxide donor. In some cases, the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum, KELTROL® BT and/or KELTROL® RD), propylene glycol, and a polysorbate surfactant such as Polysorbate 20, which combination unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.

Disclosed herein is a liquid pharmaceutical composition of botulinum toxin which is improved in stability. It comprises botulinum toxin, polysorbate 20, and methionine and optionally isoleucine. Employing, instead of the animal-derived protein albumin or gelatin, a combination of polysorbate 20 and methionine and optionally isoleucine as botulinum toxin stabilizers, the liquid pharmaceutical composition eliminates the risk of contaminating the body with serum-derived pathogens or microorganisms and can be administered safely to the body. Also, the composition is convenient for use as a direct injection for patients. Superior to conventional compositions employing either detergents or amino acids in terms of the storage stability of botulinum toxin at 25˜370 C as well as at refrigerated temperatures, the liquid pharmaceutical composition of the present invention is very useful for storing botulinum toxin under an emergency condition such as an environment without maintaining low temperature. The liquid pharmaceutical composition can be readily prepared because it employs a detergent and an amino acid(s) without a lyophilization process.

The present invention relates to mucomimetic and ophthalmic solutions comprising a cationic multimeric antimicrobial agent such as polyaminopropyl biguanide and a magnesium, calcium or magnesium/calcium complex of an anionic polymer such as hyaluronate, alginate, carboxymethyl cellulose, chondroitin sulfate or mixtures thereof. In specific embodiments, the solutions include additional components such as a surfactant, preferably polysorbate 20, a viscosity-modifying agent, preferably hydroxypropylmethyl cellulose, carboxymethyl cellulose or hydroxyethyl cellulose, a tonicity agent and a buffer. The solutions are biocompatible with and are highly comfortable when administered to mucous membranes, including those of the eye, as well as are effective disinfectants.

The invention discloses a red wine mud facial mask. The red wine mud facial mask is a dosage form which can be uncovered after coating and drying are conducted and comprises the following ingredients which comprise deionized water, wine extractives, ethanol, vinol, glycerol, butanediol, dimethyl silicone polymer, polysorbate-20, amp aminomethyl propanol, phenoxyethanol, ethylhexylglycerin, hydroxyethyl cellulose and cellulose gum. The invention further discloses a preparation method for the red wine mud facial mask. Red wine mud which is an accessory substance of wine making is applied to the field of personal care products, the red wine mud facial mask which is easy to depart and use is prepared, the red wine mud facial mask is soft and has functions of skin lighting, moisture maintaining, cutin removing and the like, and can nourish the skin and make the skin to be fine and smooth and glossy.

The invention discloses a natural Chinese prescription mouthwash, which is prepared from the following raw materials in percentage by mass: 0.2%-5.0% of a licorice extract, 0.1%-5.0% of a tea extract, 0.1%-3.0% of a scutellaria extract, 0.1%-3.0% of a cortex phellodendri extract, 0.1%-5.0% of a gallnut extract, 0.1%-5.0% of a honeysuckle extract, 0.1%-3.0% of a cassia twig extract, 0.01%-3.0% of menthyl lactate, 0.01%-3.0% of citric acid, 0.5%-8.0% of glycerinum, 0.5%-8.0% of sorbitol and 0.1%-1.0% of polysorbate-20. The mouthwash disclosed by the invention has a bacteriostasis function and is interesting in use.

The present invention provides an immunoconjugate formulation that is substantially free of particles, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of: sucrose, polysorbate 20, polysorbate 80, cyclodextrin, dextrose, glycerol, polyethylene glycol, mannitol, sodium chloride, and an amino acid, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention also provides an immunoconjugate formulation that is substantially free of aggregates, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of histidine, sucrose, glycine and sodium chloride, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention further provides an immunoconjugate formulation that is substantially free of both particles and aggregates.

The invention discloses a hair growth, hair fixation and hair care nutrient solution, the composition and mass fraction of which are as follows: SD ethanol 40-B 9-15 parts, butanediol 5-10 parts, azelaic diglycine potassium 3-8 parts, purslane extract 5-7 parts, camphor 4-9 parts, zinc sulfate 3-10 parts, pyridoxine hydrochloride 2-6 parts, panthenol 5-7 parts, sawn leaf palm fruit extract 4-8 parts, glycerin 6-9 parts, nicotinamide 4-8 parts, allantoin 6-9 parts, biotin 3-10 parts, PEG-60 hydrogenate castor oil 7-9 parts, hydrolyzed yeast protein 3-8 parts, polysorbate-20 2-6 parts, phenoxyethanol 6-10 parts, menthol 1-5 parts, hydroxybenzyl methyl ester 1-3 parts, folium Camelliae sinensis extract 8-13 parts, root extract of Glycyrrhiza glabra 11-13 parts, propolis extract 9-14 parts, azelaic diglycine potassium 7-5 parts, tripeptide-1 copper 5-8 parts, tocopherol acetate 1-3 parts, water 80-100 parts. The hair growth, hair fixation and hair care nutrient solution provided by the invention has excellent hair care effect, in particular, obvious effect on damaged hair quality, can effectively improve damaged hair quality, and can keep the hair soft and elastic.

The invention discloses sterilization antibacterial wet tissue and a making method. The sterilization antibacterial wet tissue comprises non-woven cloth and an infiltration liquid, wherein the infiltration liquid consists of the following raw materials in parts by weight: 100-200 parts of deionized water, 0.5-5 parts of lysozyme, 5-25 parts of wild chrysanthemum extract, 2-15 parts of eucommia ulmoides chlorogenic acid, 3-10 parts of aucubin, 5-20 parts of allicin, 0.05-0.3 part of potassium sorbate, 0.1-2 parts of polysorbate-20, 0-8 parts of citric acid and 0-1 part of sodium citrate. The sterilization antibacterial wet tissue is capable of rapidly removing odor and stain on tableware, melons and fruits and hands, can effectively kill and inhibit bacteria, is natural and environmental-friendly, free of alcohol or essence, comprises food-grade preservatives and emulsifiers, is safe and non-toxic, free of toxic effect on human bodies, gentle and non-pungent and free of hand damage, and has the advantages of high efficiency, security and environmental-friendliness.

The invention provides a sleeping mask with a long-lasting moisturizing effect. The sleeping mask is prepared from the following raw materials in parts by weight: 15-18 parts of water, 4-7 parts of cyclopentapolydimethylsiloxane, 5-8 parts of 1,3-propanediol, 12-14 parts of glycerinum, 3-5 parts of polydimethylsiloxane, 2-5 parts of betaine, 5-8 parts of 1,2-hexanediol, 13-15 parts of ammonium acrolyldimethyl taurine/VP copolymer, 12-18 parts of dimethiconol, 15-17 parts of phenoxyethanol, 6-8 parts of Carbomer and 5-7 parts of polysorbate-20. The sleeping mask provided by the invention has the advantages that the sleeping mask contains multiple plant components, is capable of reducing dry and thirsty wrinkles of skin, softening and moistening the skin, recovering skin elasticity, and cleaning pores; the skin feels more comfortable, and is clean and gorgeously glows on the next day; the sleeping mask can be used overnight, the defects that massage cream needs to be washed and cannot be frequently used are remedied.

The invention relates to an oil-in-water emulsifiable paste, and particularly relates to an oil-in-water emulsifiable paste with high stable performance. The oil-in-water emulsifiable paste comprises the following components: deionized water, ethylhexyl palmitate, aloe extract, petrolatum, glycerol, polydimethylsiloxane, mineral oil, cetostearyl alcohol, cetearyl glucoside, steareth-21, phenoxyethanol, acrylamide/acrylic acid copolymer, allantoin, xanthan gum, methyl hydroxybenzoate, acrylics/C10-30 alkyl alcohol acrylate cross-linked polymer, EDTA (ethylenediaminetetraacetic acid) disodium salt, ethylhexylglycerin, polyisobutene and polysorbate-20. The invention further provides a preparation method for the oil-in-water emulsifiable paste. According to the oil-in-water emulsifiable paste and the preparation method for the same disclosed by the invention, oil and active matters are re-emulsified, thus reducing the influence of the oil and the active matters which are not included by water on stability, and improving the stable performance of the oil-in-water emulsifiable paste; simultaneously, more oil can be added, and lots of active substances can be added at a low temperature.

The present invention is directed to stable liquid growth hormone formulations that remain stable after physical agitation, and after exposure to one or more freeze-thaw events. Formulations of the present invention can be stored long term at a variety of temperatures, even frozen. In the present invention, a combination of buffer and stabilizing agents, including a non-ionic surfactant (e.g., polysorbate 20), a polymer stabilizer (e.g., polyethylene glycol), and other optional stabilizers combine to provide unexpected stability to aqueous formulations of a growth hormone (e.g., human growth hormone).

The invention relates to the technical field of cosmetics, in particular to wrinkle-resistant skin-rejuvenating essence. The wrinkle-resisting skin-rejuvenation essence comprises millet polypeptide powder, nano pearl powder, a chlorella extract, tremella polysaccharide, a natural plant extract, ceramide 3, olive oil, squalane, sodium hyaluronate, glycerol, sodium lactate, sodium pyrrolidone carboxylate, an antioxidant, polysorbate-20 and a proper amount of mountain spring water. The wrinkle-resistant skin-rejuvenating essence has the advantages of good permeability, easiness in absorption, moisture retention and skin moistening according to the biological rhythm of the skin, effective repair of skin wrinkles, inhibition of wrinkle regeneration, delay of skin aging and high biocompatibilitywith the skin.

The invention relates to a pet deodorizing and odor removing wet tissue and a method for manufacturing the same. The pet deodorizing and odor removing wet tissue comprises a non-woven fabric. The non-woven fabric is used as a carrier for pet deodorizing and odor removing cleaning liquid, the weight ratio of the pet deodorizing and odor removing cleaning liquid to the carrier is 3-3.5:1, the pet deodorizing and odor removing cleaning liquid comprises, by weight, 1%-3% of sodium dodecyl sulfate or sodium cocoamphoacetate or polysorbates 20, 1%-5% of propylene glycol or polyether triols-26 or dipropylene glycol, 0.1%-3% of plant extract liquid, 0.1%-3% of PEG (polyethylene glycol)-75 lanolin or silicone quaternium-17 or dimethyl siloxane, 0.2% of daily use chemical essence, 0.3%-0.6% of phenoxyethanol or polyaminopropyl biguanide or benzalkonium chloride, 0.1% of disodium EDTA (ethylene diamine tetraacetic acid), 0.1%-1% of citric acid and 84.1%-97.1% of deionized water. The pet deodorizing and odor removing wet tissue and the method have the advantages that the method is simple and safe and is free of pollution; the pet deodorizing and odor removing wet tissue is mild, has light fragrance and is free of irritation, and the hair of pets can be conditioned and protected and has certain gloss.

The invention discloses cosmetic containing methyl-pyrimidine type substances. The cosmetic is prepared from ectoine, fullerene, butylene glycol, allantoin, polyquaternium-51, hyaluronic acid, sweet orange flower extracts, lily pad embryo extracts, lalang grass rhizome extracts, panthenol, beta-glucose, EDTA (ethylene diamine tetraacetic acid) disodium, xanthan gum, imidazolidinyl urea, iodopropynyl butylcarbamate, polysorbate 20, polysorbate 80, glycerin and pure water. Ectoine, the lily pad embryo extracts and fullerene are compounded in a specific formula, so that the prepared cosmetic has very remarkable anti-wrinkling and moisturizing effects and can remarkably reduce skin lines, reduce the depth of wrinkles, reduce the surface roughness of skin, improve skin peeling rate, enhance the skin elasticity, repair crow's-feet and keep the skin moist and full for a long time, and the skin looks more smooth, healthier and younger.

A composition is provided for reducing incidents of hot flashes experienced by menopausal women, the composition comprising a mixture of water, a thickener, sorbitan monolaurate, cocoa butter or shea butter, polysorbate 20, dimethicone 200, bacteriacide, a pH adjuster and an effective amount of Chinese black cohosh. A method is also provided for preparing the composition and its use by menopausal women in need of treatment of hot flashes.

The invention relates to the technical field of cosmetics and discloses a cleansing lotion with the capabilities of replenishing water and dispelling dirt. The cleansing lotion with the capabilities of replenishing water and dispelling dirt is prepared from the following components in percentage by weight: 1-5 percent of butanediol, 5-23 percent of propanediol, 5-8 percent of potassium cocoyl glycinate, 3-5 percent of potassium myristoyl glutamate, 0.3-1.6 percent of glycerol, 3-12 percent of polysorbate-20, 1-7 percent of polysorbate-85, 2-5 percent of PEG-7 glyceryl cocoate, 0.01-0.03 percent of hyaluronic acid, 1.5-4 percent of a rheological agent, 0.3-1.0 percent of a skin conditioner, 1-3 percent of a lilium brownie extract, 1-3 percent of a lavender extract, 45-65 percent of water, 0-0.05 percent of a perfume and 0-0.5 percent of a preservative. The cleansing lotion with the capabilities of replenishing water and dispelling dirt has the effect of softening horniness, is capable of deeply cleaning pores, purifying black heads in the pores, deeply replenishing water and smoothing skin texture so as to get rid of the skin problems of black heads, acne, dull skin and the like, is mild and safe and is also capable of removing and discharging various residual cosmetics which are difficultly removed, maintaining beauty and keeping young in addition to having the functions of removing the cosmetics, cleansing face and replenishing water.

The invention discloses a facial mask composition containing natural volcanic mud, which is composed of the following raw material components in weight percentage: 2.0%-6.0% of glycerin, 20.0%-50.0% of Wudalianchi medicinal mineral mud, and 1.0% of stearyl alcohol ~4.0%, glyceryl stearate 0.5%~1.8%, 1,3-propylene glycol 0.5%~3.0%, stearic acid 2.0%~4.0%, hydroxyethyl cellulose 0.1%~1.0%, polyvinyl alcohol 0.5% %~2.0%, Isopropyl palmitate 2.0%~8.0%, Vitamin C 0.1%~0.5%, Dimethicone 1.0%~6.0%, Polysorbate-20 0.3%~1.2%, Hyaluronic acid 0.01% to 0.05% sodium nitrate, 1.0% to 5.0% sweet almond oil, 0.05% to 0.1% ethyl paraben, 0.01% to 0.1% essence, and the balance is Wudalianchi mineral water. The present invention adopts the combination of Wudalianchi's products (volcanic mineral water and medicinal mineral mud) to increase skin elasticity, gloss, safety, and antibacterial performance, which is far superior to similar mud film products on the market.