Medical micro-hole composite hemostatic material and preparing method thereof

A hemostatic material and microporous technology, applied in the field of biomedical hemostatic materials, can solve problems such as unsatisfactory hemostatic effect, insufficient hemostatic speed, and restrictions on wide application, and achieve the effects of enhancing hemostatic effect, promoting wound healing, and activating the blood coagulation system

Inactive Publication Date: 2016-06-22
广西达庆生物科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the hemostatic effect of these current technologies is not ideal, and the hemostatic speed is not fast enough, which limits its wide application in clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] A medical microporous composite hemostatic material is composed of the following raw materials in weight percentage:

[0082] Collagen 20%

[0083] Hyaluronic Acid 40%

[0084] Puffball spore powder 20%

[0085] Hemostatic Chinese medicine extract 20%.

[0086] The hyaluronic acid is a pharmaceutical grade powder with an average molecular weight of 500 Daltons.

[0087] The collagen is medical grade collagen with an average molecular weight of 1000 Daltons.

[0088] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 110 degrees Celsius, crushing and passing through a sieve of more than 100 mesh.

[0089] The hemostatic traditional Chinese medicine extract is a mixture of 10 parts of large thistle extract and 20 parts of small thistle extract.

[0090] The above-mentioned collagen, hyaluronic acid, puffball spore powder and hemostatic tra...

Embodiment 2

[0092] A medical microporous composite hemostatic material is composed of the following raw materials in weight percentage:

[0093] Collagen 40%

[0094] Hyaluronic Acid 20%

[0095] Puffball spore powder 25%

[0096] Hemostatic Chinese medicine extract 15%.

[0097] The hyaluronic acid is a pharmaceutical grade powder with an average molecular weight of 2000 Daltons.

[0098] The collagen is medical grade collagen with an average molecular weight of 500 Daltons.

[0099] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 120 degrees Celsius, and passing through a sieve with a mesh size of 100 or more after crushing.

[0100] The hemostatic traditional Chinese medicine extract is a mixture composed of 20 parts of Burnet ulmus extract, 40 parts of Ramie root extract, 30 parts of Sophora japonica extract, 30 parts of Puhuang extract and 25 parts ...

Embodiment 3

[0104] A medical microporous composite hemostatic material is composed of the following raw materials in weight percentage:

[0105] Collagen 30%

[0106] Hyaluronic Acid 25%

[0107] Puffball spore powder 20%

[0108] Hemostatic Chinese medicine extract 25%.

[0109] The hyaluronic acid is a pharmaceutical grade powder with an average molecular weight of 1200 Daltons.

[0110] The collagen is medical grade collagen with an average molecular weight of 900 Daltons.

[0111] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 130 degrees Celsius, and passing through a sieve with a mesh size of 100 or more after crushing.

[0112] The hemostatic traditional Chinese medicine extract is 10 parts of Burnet extract, 20 parts of Rubia extract, 20 parts of Imperata rhizome extract, 10 parts of Cockscomb flower extract, 20 parts of Duanxueliu extract, 5 pa...

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Abstract

The invention relates to a biological medical hemostatic material, in particular to a medical micro-hole composite hemostatic material and a preparing method thereof. The medical micro-hole composite hemostatic material is formed by collagen, hyaluronic acid, puffball conidial powder and hemostatic Chinese herb extracts, wherein the collagen can quickly combine with hemoglobin in blood to form hemostatic coagulum, the hyaluronic acid can timely absorb water in the blood to form hydrogel to plug exudation, and the puffball conidial powder contains a lot of porous fiber which can quickly absorb water in the blood and mechanically plug crevasses of a blood vessel and exudation of blood capillaries. The three matters can form physical barriers to isolate a wound and achieve effects of preventing adhesion and stopping bleeding timely. The hemostatic Chinese herb extracts have effects of stopping bleeding, resisting inflammation, resisting bacteria, easing pain, cooling blood, eliminating stasis, subduing swelling, performing convergence, activating a coagulating system and promoting wound healing. The four matters organically combine with each other, are obvious in hemostatic effect, are suitable for hemostasis of all kinds of wound, fresh tissue wound surface exudation, small blood vessel hemorrhage and bleeding areas and can prevent adhesion.

Description

technical field [0001] The invention relates to the technical field of biomedical hemostatic materials, in particular to a medical microporous composite hemostatic material and a preparation method thereof. Background technique [0002] Hemostasis is an important link in the operation of various departments in the hospital, and plays a considerable role in the success of the operation and the safety of the patient. The normal hemostasis mechanism mainly includes three aspects: the contraction of small blood vessels, the activation of platelets and the activation of the coagulation system. Among them, the contraction of small blood vessels is the earliest response to hemostasis after trauma. After the blood vessels are damaged, the smooth muscles of the blood vessels constrict the blood vessels and slow down the blood flow through axon reflex, which is beneficial to blood coagulation and hemostasis. Platelets have the physiological function of adhering to the surface of woun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/08A61L24/00A61K36/899A61P7/04A61K35/36
CPCA61L24/08A61K35/36A61K36/14A61K36/185A61K36/258A61K36/28A61K36/489A61K36/53A61K36/62A61K36/739A61K36/74A61K36/88A61K36/898A61K36/899A61L24/0005A61L24/0015A61L24/102A61L2300/30A61L2300/404A61L2300/412A61L2300/418A61L2400/04C08L89/00C08L5/08A61K2300/00
Inventor 梁奕福
Owner 广西达庆生物科技有限公司
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