Oriented loading system and directional method for loading particles in wells
A technology for loading systems and particles, applied to chemical instruments and methods, measuring devices, containers for laboratories, etc., can solve problems such as the inability to use large measurement methods
Active Publication Date: 2019-01-29
PERSONAL GENOMICS INC
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- Application Information
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Problems solved by technology
However, in many cases, it is not possible to use a large number of measurement methods, for example, when the sample volume is too small or the concentration of the target molecule is too low for a given technology, the detection sensitivity of the target molecule is limited
Method used
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Embodiment 1
[0083] Embodiment 1, the synthesis of cysteine-betaine silane (cysteine-betaine (CB) silane)
[0084] Synthetic steps:
[0085]
[0086] Mix trimethoxy[(3-methylamino)propyl]silane with ethyl 4-bromobutanoate at a molar ratio of 1:1.3 in acetonitrile (ACN) and reflux for 72 hours. The product was dried with a lyophilizer. For glass surface modification, oxygen plasma treated glass was immersed in 1 (v / v)% product dissolved in ethanol for 1 hour. After treating with 2.5M hydrochloric acid for 30 minutes to hydrolyze the ethyl group, the glass grafted with cysteine-betaine (CB) functional groups can be obtained.
Embodiment 2
[0087]Embodiment 2, the synthesis of sulfo-betaine silane (sulfo-betaine (SB) silane)
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Abstract
The present disclosure provides a directional loading system. The directional loading system includes: a substrate; a plurality of wells formed in the substrate, each well having a bottom and sidewalls; a plurality of particles loaded in the wells, wherein the particles include a core structure and an inner layer , the inner layer includes magnetic material and partially covers the core structure such that a portion of the core structure not covering the inner layer is exposed; and a metal layer includes magnetic material and is partially deposited in the sidewalls of the wells, Wherein the metallic layer attracts the inner layer such that the exposed core structure is oriented towards the bottom of the well, or the inner layer is oriented towards the bottom of the well. The directional loading system of the present disclosure can improve the loading efficiency of the analyte molecule and clearly detect the signal of the analyte molecule. The present disclosure also provides an orientation method for loading particles into wells.
Description
technical field [0001] The present disclosure relates to a loading system, and more particularly to a directional loading system and a directional method for loading particles into wells. Background technique [0002] Most traditional chemical or biochemical analyzes are based on "bulk" measurements. In these measurements, the collective behavior of multiple molecules within a volume of a sample solution is measured to determine molecular properties. However, in many cases, it is not possible to use a large number of measurement methods, for example, when the sample volume is too small or the concentration of the target molecule is too low for a given technology, the detection sensitivity of the target molecule is limited . In recent years, detection of single analyte molecules has become possible. And single molecule detection can provide higher sensitivity and more detailed information than traditional mass measurement. The development of single-molecule instrument sen...
Claims
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IPC IPC(8): G01N35/10
CPCG01N35/10B01J2219/00317B01J2219/00468B01J2219/005B01L3/502761B01L3/5085B01L2200/025B01L2200/0647B01L2200/0663B01L2200/0668B01L2300/0809B01L2300/0829B01L2300/0858B01L2300/0887B01L2400/043G01N1/2813
Inventor 蔡经纬谢馨仪彭于瑄陈文逸黄俊仁
Owner PERSONAL GENOMICS INC