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Application of imidafenacin in preparation of drugs for pre-anesthetic medication

A new technology of midana and drugs, which is applied in anesthetics, drug combinations, nervous system diseases, etc.

Inactive Publication Date: 2016-07-27
张蕊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the use of midanacin as a pre-anesthesia drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] In order to further illustrate the beneficial effect of the technical solution of the present invention, we verify by the drug effect experiment, and the drug effect experiment is as follows:

[0012] Experiment 1 Effects of midanacin on isolated rat submandibular gland

[0013] 1 Experimental materials

[0014] 1.1 Experimental animals: SPF grade adult male SD rats, provided by the Experimental Animal Research Center of Chengdu University of Traditional Chinese Medicine, weighing 220-280g, a total of 30, 6 in each group, pre-feeding for 1 week, and the rat feed is full-price rat pellets The materials were provided by the farm of the Special Committee of Experimental Animals of Sichuan Province.

[0015] 1.2 Experimental drugs:

[0016] Midanacine, Atropine Sulfate, CCh (Carbachol).

[0017] 1.3 Experimental equipment:

[0018] Ultra-clean workbench, electronic balance, methyl fluoride fiber tube, BF-41 constant temperature water bath, peristaltic pump.

[0019] 2....

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PUM

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Abstract

The invention discloses application of imidafenacin in preparation of drugs for pre-anesthetic medication. Preclinical pharmacological tests prove that imidafenacin not only can be used for pre-anesthetic medication, but also has effects superior to those of atropine, thus opening up a new path for clinical pre-anesthetic medication.

Description

technical field [0001] The technical solution of the invention relates to a new application of mida, and belongs to the technical field of medicine. Background technique [0002] The purpose of medication before anesthesia is to relieve the patient’s anxiety, fear, anxiety, etc., reduce the secretion of saliva and respiratory tract during anesthesia, so as to keep the respiratory tract unobstructed, facilitate the management of the respiratory tract during operation and reduce postoperative pulmonary complications. Prevent complications such as bradycardia and laryngeal spasm caused by intraoperative stimulation, induction of vagal reflex or other visceral reflexes. The classic pre-anesthesia drug is atropine, because it is a non-selective drug that antagonizes M cholinergic receptors, it often causes adverse reactions such as increased heart rate, postoperative urinary retention and intestinal paralysis; Excitement symptoms such as irritability and hallucinations are espec...

Claims

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Application Information

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IPC IPC(8): A61K31/4174A61P25/20A61P23/00
Inventor 张蕊金洪伟
Owner 张蕊
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