Orally rapidly disintegrating tablet comprising imidafenacin

Abstract

Provided herein is an imidafenacin-containing orally rapidly disintegrating tablet which is excellent in the photostability. The orally rapidly disintegrating tablets comprises (1) a granulated product containing imidafenacin or imidafenacin particles, which is or are coated with povidone or a gastric juice-soluble polymer; and (2) a composition containing an excipient and a disintegrating agent, wherein the resulting composition is subjected to compression molding.

Description

technical field

[0001] The present invention relates to an orally rapidly disintegrating tablet containing imidafenacin as an active ingredient. Background technique

[0002] Midanacin is a compound having muscarinic receptor M3 and M1 antagonistic activity (Patent Document 1), and is provided as a therapeutic drug for overactive bladder (Non-Patent Document 1). Oral solid preparations, percutaneous absorption preparations and the like containing midanacin are known as pharmaceutical formulations containing midanacin as a main component (Patent Documents 2 and 3).

[0003] Patent Document 2 describes that since the midanacin preparation is unstable to light, photostability is achieved by coating a tablet with a coating liquid containing titanium oxide and ferric oxide. However, Patent Document 2 does not disclose the case where a coating is applied to the midanacin granules before tableting for photostabilization.

[0004] In addition, Patent Document 3 is a percutaneous a...

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