Orally rapidly disintegrating tablet comprising imidafenacin

一种迅速崩解、口腔内的技术，应用在含有效成分的医用配制品、有机活性成分、非有效成分的医用配制品等方向，达到给药容易、崩解性优异、光稳定性优异的效果

Active Publication Date: 2013-08-14
XINGLIN HLDG CO LTD
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, it is difficult to coat the tablet with titanium oxide and ferric oxide while maintaining the disintegrating properties of the orally disintegrating tablet. agent has not yet been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Orally rapidly disintegrating tablet comprising imidafenacin
  • Orally rapidly disintegrating tablet comprising imidafenacin

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0039] In the preparation of the orally rapidly disintegrating tablet of the present invention, the coated granules containing midanacin or midanacin granules are mixed with a composition containing an excipient and a disintegrating agent. The amount of the composition containing the excipient and the disintegrating agent is, for example, 1 to 50 parts by mass, preferably 3 to 25 parts by mass, relative to 1 part by mass of the coated granulated product containing midanacine or midanacin granules. parts by mass.

[0040] The coated granules or midancin granules containing excipients and disintegrants, for example, can be prepared in a V-shaped mixer, a diamond mixer (diamond mixer), a drum Mixing in a mixer or the like.

[0041] Then, the resulting mixture is compression-molded to prepare the orally rapidly disintegrating tablet of the present invention.

[0042]Compression molding can be performed suitably using a tablet press such as a rotary tablet press, for example. Ho...

Embodiment 1

[0068] 4.0 g of midanacin and 2 g of Kollidon 90F (BASF) were dissolved in a mixed solution of 118.2 g of pure water and 275.8 g of ethanol. 394 g of Starch 1500G (Japanese カラコン) was loaded into a rotary fluidized bed granulator (manufactured by Dalton, NQ-160), and the solution was coated by top spray method (spray liquid volume 15g / min, spray pressure 0.1MPa, air supply temperature 70° C.) to obtain granules containing midanacin.

[0069] Separately, 60 g of a stomach-soluble polymer, EUDRAGIT EPO (Rohm GmbH & Co. KG), and 30 g of magnesium stearate (vegetable) (Taihei Chemical Industry) were dissolved in a mixed solution of 273 g of pure water and 637 g of ethanol.

[0070] 300 g of granulated matter containing midanacin was charged into a rotary fluidized bed granulator (manufactured by Dalton, NQ-160), and the solution was applied by the top spray method (spray liquid volume 20 g / min, spray pressure 0.15 MPa, Air supply temperature 80°C) to obtain coated particles.

[0...

Embodiment 2

[0073] 25.0 g of midanacin and 12.5 g of Kollidon 90F (BASF) were dissolved in a mixed solution of 738.75 g of pure water and 1723.75 g of ethanol. Starch 1500G (Japanese カラコン) 4962.5g is packed into a fluidized bed granulator (manufactured by FLOINT INDUSTRY, FL-5), and the solution is coated by the top spray method (spray liquid amount 100g / min, spray pressure 0.3MPa, air supply temperature 70° C.) to obtain midanacin-containing granules (average particle diameter: 128 μm). Separately, 750 g of EUDRAGITEPO (Rohm GmbH & Co. KG) and 375 g of magnesium stearate (vegetable) (Taihei Chemical Industry) were dissolved in a mixed solution of 3412.5 g of pure water and 7962.5 g of ethanol. 3750 g of the granulated matter containing midanacin was charged into a fluidized bed granulator (manufactured by Floint Industries, FL-5), and the solution was coated by the top spray method (spray liquid volume 100 g / min, spray pressure 0.3 MPa, Supply air temperature: 80° C.) to obtain coated p...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Provided herein is an imidafenacin-containing orally rapidly disintegrating tablet which is excellent in the photostability. The orally rapidly disintegrating tablets comprises (1) a granulated product containing imidafenacin or imidafenacin particles, which is or are coated with povidone or a gastric juice-soluble polymer; and (2) a composition containing an excipient and a disintegrating agent, wherein the resulting composition is subjected to compression molding.

Description

technical field [0001] The present invention relates to an orally rapidly disintegrating tablet containing imidafenacin as an active ingredient. Background technique [0002] Midanacin is a compound having muscarinic receptor M3 and M1 antagonistic activity (Patent Document 1), and is provided as a therapeutic drug for overactive bladder (Non-Patent Document 1). Oral solid preparations, percutaneous absorption preparations and the like containing midanacin are known as pharmaceutical formulations containing midanacin as a main component (Patent Documents 2 and 3). [0003] Patent Document 2 describes that since the midanacin preparation is unstable to light, photostability is achieved by coating a tablet with a coating liquid containing titanium oxide and ferric oxide. However, Patent Document 2 does not disclose the case where a coating is applied to the midanacin granules before tableting for photostabilization. [0004] In addition, Patent Document 3 is a percutaneous a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4164A61K9/20A61K47/32A61K47/36A61K47/38A61P13/10
CPCA61K9/205A61K9/2018A61K31/4164A61K9/0056A61K9/1652A61K9/5026A61P13/06A61P13/10
Inventor 石崎敏广青木芳延
Owner XINGLIN HLDG CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap