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Protein and polypeptide liquid stabilizer

A liquid stabilizer and protein technology, applied in the field of protein and polypeptide liquid stabilizers, can solve the problems of inconsistent viscosity and serum plasma, harsh transportation and storage, complicated production process, etc., and achieves low production cost, easy transportation and storage. , the effect of long stability

Inactive Publication Date: 2016-07-27
RELIA BIOTECH JIANGSU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current quality control products on the market have inconsistent viscosity with serum plasma, are expensive, have harsh transportation and storage, complicated production process, or poor stability

Method used

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  • Protein and polypeptide liquid stabilizer
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  • Protein and polypeptide liquid stabilizer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation method of the protein and polypeptide liquid stabilizer of the present embodiment is as follows:

[0023] Weigh 20 grams of human serum albumin, 2 grams of PVP, 2 grams of sodium chloride, 200 grams of sucrose, and 0.5 grams of sodium azide, dissolve the above substances in phosphate buffer, and set the volume to 1000 ml.

Embodiment 2

[0025] The preparation method of the protein and polypeptide liquid stabilizer of the present embodiment is as follows:

[0026] Weigh 50 grams of bovine serum albumin, 1 gram of PVP, 10 grams of sodium chloride, 100 grams of sucrose, and 0.5 grams of sodium azide, dissolve the above substances in phosphate buffer, and set the volume to 1000 ml.

Embodiment 3

[0028] The preparation method of the protein and polypeptide liquid stabilizer of the present embodiment is as follows:

[0029] Weigh 5 grams of human serum albumin, 20 grams of PEG, 50 grams of sodium chloride, 10 grams of trehalose, and 0.5 grams of sodium azide, dissolve the above substances in phosphate buffer, and set the volume to 1000 ml.

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Abstract

The invention provides a protein and polypeptide liquid stabilizer. The protein and polypeptide liquid stabilizer is prepared from human or animal serum albumin, polyvinyl pyrrolidone or polyethylene glycol, sodium chloride, sucrose or trehalose, sodium azide and a phosphate buffer. The protein and polypeptide liquid stabilizer has the following technical effects: 1) the protein and polypeptide liquid stabilizer has very good protective effect on proteins and polypeptides and has longer stability; the proteins and polypeptides can be stabilized for at least 7 days when stored at the room temperature, can be stabilized for at least 12 months when stored at the temperature of 2-8 DEG C and can be stabilized for at least 24 months when stored at the temperature of subzero 20 DEG C or lower; 2) the whole configuration operation is simple, the reproducibility is good, and the production cost is low; 3) the stabilizer is in a liquid state, is not required to be redissolved, and is convenient to use and easy to transport and store; 4) the viscosity of the protein and polypeptide liquid stabilizer is close to that of serum and plasma, and the stabilizer better shows superiority in dry biochemical and immunological detection.

Description

technical field [0001] The invention relates to a protein and polypeptide liquid stabilizer, which belongs to the field of biotechnology. Background technique [0002] With the rapid development of clinical diagnosis, it is imperative to improve the accuracy of test results. The accuracy of test results is affected by many factors, such as failure of reagents and calibrators, operational errors, poor instrument maintenance, accidental factors, and so on. How to effectively reduce the errors caused by these factors, there is no doubt that the use of quality control products can eliminate some errors to a certain extent. A quality control substance (fixed and non-fixed) usable in in vitro diagnostics is a substance, material, article or device intended for use in a test system intended for medical use, the purpose of which is to evaluate or verify measurement precision, Measurement accuracy, performance characteristics such as possible analytical bias of the detection system...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/68
Inventor 刘建源何晓红
Owner RELIA BIOTECH JIANGSU
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