A kind of flunarizine hydrochloride pharmaceutical composition

A technology of flunarizine hydrochloride and flunarizine hydrochloride tablets, which can be used in drug combinations, pharmaceutical formulations, nervous system diseases, etc., can solve problems such as uneven dissolution and looseness of drugs

Active Publication Date: 2019-07-12
DISHA PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Purpose of the invention: to solve the problem of uneven drug dissolution and the phenomenon of loosening after long-term storage

Method used

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  • A kind of flunarizine hydrochloride pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Flunarizine hydrochloride 5.9g, lactose 62.5g, microcrystalline cellulose 70g, sodium carboxymethylcellulose 3.2g, silicon dioxide 0.8g, magnesium stearate 0.8g, docusate sodium 1g, according to the technical plan The above preparation method prepares 1000 tablets.

Embodiment 2

[0023] Flunarizine hydrochloride 5.9g, lactose 82.5g, microcrystalline cellulose 90g, carmellose sodium 12.8g, silicon dioxide 0.8g, magnesium stearate 0.8g, docusate sodium 1.6g, according to the technical proposal The preparation method prepares 1000 tablets.

Embodiment 3

[0024] Embodiment 3, flunarizine hydrochloride 5.9g, lactose 70g, microcrystalline cellulose 80g, sodium carboxymethylcellulose 5g, silicon dioxide 0.8g, magnesium stearate 0.8g, docusate sodium 1.3g, press The preparation method described in the technical solution prepares 1000 tablets.

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Abstract

The invention relates to a flunarizine-hydrochloride pharmaceutical composition and a preparing method thereof, and belongs to the technical field of medicine making. The flunarizine-hydrochloride pharmaceutical composition in the technical scheme is characterized in that every one thousand compositions comprise 5.9 g of flunarizine hydrochloride, 62.5 g-82.5 g of lactose, 70 g-90 g of microcrystalline cellulose, 3.2-12.8 g of sodium carboxymethylcellulose, 0.8 g of silicon dioxide, 0.8 g of magnesium stearate and 1-1.6 g of docusate sodium. According to the flunarizine-hydrochloride pharmaceutical composition and the preparing method thereof, a tablet with the small resolving degree RSD is provided through reasonable compatibility, the prepared tablet is stable in long-term storage, and high-quality medicine is provided for a clinic.

Description

technical field [0001] The invention relates to a flunarizine hydrochloride pharmaceutical composition and a preparation method thereof, belonging to the technical field of pharmacy. Background technique [0002] Flunarizine hydrochloride is a calcium channel blocker that can prevent cell damage caused by intracellular pathological calcium overload caused by ischemia and other reasons. The drug was launched in my country in 1989. The drug has many advantages such as strong curative effect, good safety, low side effects, and good patient compliance. In the field of preventive treatment of typical (with aura) or atypical (without aura) migraine and symptomatic treatment of vertigo caused by vestibular dysfunction, flunarizine hydrochloride preparations are welcomed by doctors and patients, with global sales year by year rise. [0003] The commercially available flunarizine hydrochloride tablets are 5 mg (calculated as flunarizine), which belongs to small-scale preparations. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/495A61K9/20A61K47/26A61K47/20A61P25/06A61P1/08
CPCA61K9/2013A61K9/2018A61K31/495
Inventor 祁伟力孟庆举梁君刘人仆张永强
Owner DISHA PHARMA GRP
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