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Vonoprazan fumarate dispersible tablets and preparation method thereof

A technology of vornorazan fumarate and vornola fumarate is applied in the directions of medical preparations without active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve problems such as slow onset of action, etc. To achieve the effect of less intestinal residue, fast disintegration and fast absorption

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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect needs to be activated after concentrated activation of the stomach wall, the onset of effect is slow, and the maximum curative effect is reached after multiple administrations (usually after one week). The duration of action is affected by the half-life of the plasma drug. The half-life effect of

Method used

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  • Vonoprazan fumarate dispersible tablets and preparation method thereof
  • Vonoprazan fumarate dispersible tablets and preparation method thereof
  • Vonoprazan fumarate dispersible tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0020] prescription:

[0021]

[0022] Preparation:

[0023] (1) Mix Vonorazan fumarate powder (200 mesh) and sucrose powder (150 mesh) in equal increments to obtain mixture A;

[0024] (2) Pass the remaining auxiliary materials through a 200-mesh sieve, and mix them uniformly in equal increments to obtain mixture B;

[0025] (3) Mix mixture A and mixture B uniformly according to the method of equal increase, and then directly compress into tablets.

Embodiment 2

[0027] prescription:

[0028]

[0029] Preparation:

[0030] (1) Mix Vonorazan fumarate powder (200 mesh) and lactose powder (150 mesh) in equal increments to obtain mixture A;

[0031] (2) Pass the remaining auxiliary materials through a 200-mesh sieve, and mix them uniformly in equal increments to obtain mixture B;

[0032] (3) Mix mixture A and mixture B uniformly according to the method of equal increase, and then directly compress into tablets.

Embodiment 3

[0034] prescription:

[0035]

[0036] Preparation:

[0037] (1) Mix Vonorazan fumarate powder (200 mesh) and lactose powder (150 mesh) in equal increments to obtain mixture A;

[0038] (2) Pass the remaining auxiliary materials through a 200-mesh sieve, and mix them uniformly in equal increments to obtain mixture B;

[0039] (3) Mix mixture A and mixture B uniformly according to the method of equal increase, and then directly compress into tablets.

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PUM

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Abstract

The invention discloses vonoprazan fumarate dispersible tablets, used for treating gastric and duodenal ulcers. The vonoprazan fumarate dispersible tablets are prepared from vonoprazan fumarate, with the addition of adjuvant materials. The vonoprazan fumarate dispersible tablets are rapid in disintegration and absorption, high in bioavailability, convenient to take, low in content of intestinal residues, light in side effects, sweet in taste and fragrant; and especially, the dispersible tablets are easy to improve the medication compliance of patients.

Description

technical field [0001] The invention relates to a new formulation of vonoprazan fumarate, in particular to vonoprazan fumarate tablets and a preparation method thereof. Background technique [0002] Vonoprazan fumarate is a pyrrole derivative developed by Takeda, Japan. It is a potassium ion competitive acid blocker, which reduces gastric acid secretion by inhibiting the binding of K to H, K-ATPase. [0003] Excessive secretion of gastric acid can cause peptic ulcer. Proton pump inhibitors are commonly used clinically. Proton pump inhibitors are divided into irreversible and reversible types according to their binding mode with H+K+-ATPase. Now the main clinical application is irreversible. This type of inhibitor has the phenomenon of acid breakthrough at night, which affects the curative effect, resulting in a failure to achieve a good therapeutic effect. Vonorazan is a new type of reversible PPI-potassium ion competitive acid blocker. [0004] The concentration distribu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4439A61K47/20A61K47/34A61K47/22A61K47/26A61P1/04
CPCA61K9/0056A61K9/2013A61K9/2018A61K9/2031A61K31/4439A61K47/10A61K47/20A61K47/22A61K47/26
Inventor 王雪峰韩亮
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