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Prophylactic agent for pneumococcal infection

A technology for prevention of pneumococcus and infection, applied in the direction of bacteria, lactobacilli, antibacterial drugs, etc., can solve the problem of not seeing pneumococcus, etc., and achieve the effect of preventing aggravation and preventing infection

Inactive Publication Date: 2016-11-09
MEIJI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there have been no reports that lactic acid bacteria other than the B240 strain contribute to the prevention of pneumococcal infection and the prevention of aggravation of the infection.

Method used

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  • Prophylactic agent for pneumococcal infection
  • Prophylactic agent for pneumococcal infection
  • Prophylactic agent for pneumococcal infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 〔Preparation of fermented product〕

[0037] Lactobacillus bulgaricus strain R-1 was added as a starter bacterium to a solution (fermented milk mix) prepared mainly with skim milk powder, and fermented at 37° C. for 16 hours. The amount of exopolysaccharides in the fermented product (fermented milk) was measured, and the dose to mice was calculated. In addition, in the method for measuring the amount of extracellular polysaccharides, the fermented product is deproteinized with trichloroacetic acid, and polysaccharides (exopolysaccharides) are precipitated and purified by ethanol precipitation. Then, the amount of the precipitated polysaccharides (exopolysaccharides) was measured by HPLC in gel filtration mode. In addition, the fermented product (fermented milk) contained 725 μg / g exopolysaccharides and 1.7×10 9 CFU / g of lactic acid bacteria.

[0038] 〔Validation of the lung infection model (1)〕

[0039] (infection to lung of mouse)

[0040] In C57BL / 6 mice (female, ...

Embodiment 2

[0044] 〔Validation of the lung infection model (2)〕

[0045] (infection to upper respiratory tract of mouse)

[0046] In C57BL / 6 mice (female, 8-week-old, n=9 or 10), throughout the test period, the fermented milk administration group was orally administered (once / day, before administration) 21 days and after administration) a fermentation product of Lactobacillus bulgaricus R-1 strain (50 μg / mouse of exopolysaccharides). In addition, a solution (fermented milk Mix) prepared with skim milk powder as a main component was orally administered to the control group. On day 22 from the start of these oral administrations, nasal inoculation (1×10 7 CFU / mouse) Streptococcus pneumoniae 1121 strain suspension. Then, after the pneumococcus inoculation, the number of attached bacteria in the upper airway (the number of pneumococci attached to the upper airway) was compared among the groups.

[0047] However, the number of attached bacteria in the upper respiratory tract was measured a...

Embodiment 3

[0051] Add Lactobacillus delbrueckii ssp.bulgaricus OLL1073R-1 and Streptococcus thermophilus extracted from Meiji Lactobacillus bulgaricus yoghurt as starter bacteria to a mixture containing dairy products, sugar, and raw material water , and ferment. Liquid sugar, granulated sugar, pectin, and raw material water are added to this fermented product (cultivation) to manufacture drink-type yoghurt. When a panel of 10 people ingested this yoghurt, all 10 people evaluated that the flavor was good.

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PUM

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Abstract

[Problem] To provide a composition for preventing the infection by a pneumococcus and preventing or inhibiting the infection from becoming severe during the occurrence of the infection. [Solution] A fermentation product of Lactobacillus delbrueckii ssp. Bulgaricus strain OLL1073R-1 which preferably contains living bodies of the bacterium, is used as a prophylactic agent for pneumococcal infection. The fermentation product is, for example, yoghurt or a lactic acid bacterium beverage. When a normal person ingests the fermentation product, it becomes possible to prevent the infection by a pneumococcus and to prevent or inhibit the infection from becoming severe during the occurrence of the infection.

Description

technical field [0001] The present invention provides a prophylactic agent for pneumococcal infection, that is, a composition for preventing pneumococcal infection, preventing and suppressing the aggravation of the infection. Background technique [0002] Streptococcus pneumoniae, also known as pneumococcus, can cause respiratory infections such as pneumonia and systemic infections when infected. In particular, there are many cases of death due to pneumococcal infection in the elderly, infants and the like. In addition, in the case of pneumococcal infection, penicillin-type antibiotics are administered. In addition, vaccines are usually administered to prevent pneumococcal infection. [0003] However, in the administration of antibiotics, a sufficient therapeutic effect may not be expected due to the emergence of resistant bacteria. In addition, the administration of vaccines has the disadvantages that side effects may occur and high costs are required. Therefore, safe a...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P11/00A61P31/04C12N1/20C12R1/225C12R1/46
CPCC12N1/20A61K35/744A61K35/747A23L33/135A23C9/1238A23V2002/00A23L7/00A23L5/00A23L21/00A61P11/00A61P31/04C12R2001/225C12N1/205A23V2400/123A61K2300/00A23V2200/314A23V2200/3202
Inventor 中村茂树大岛一浩河野茂池上秀二
Owner MEIJI CO LTD
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