Clean kitasamycin extraction process

Abstract

The invention belongs to an antibiotic production process and particularly relates to a clean kitasamycin extraction process. The clean kitasamycin extraction process comprises the steps of fermentation broth acidification, filtration, extraction, raffinate recovery and the like. In an existing production process, extracted raffinate is subjected to harmless treatment and then is always and directly discharged. According to the clean kitasamycin extraction process, it is considered that the main component of the raffinate is water based on relevant production technology study, the raffinate can be reused for the production process after being treated properly, the sewage treatment cost can be better reduced while water resources are saved in use, and accordingly production benefits are improved. The process overcomes the technical prejudice on direct discharge of production wastewater to some degree. Compared with existing production processes, the clean kitasamycin extraction process is lower in improvement cost and is simple. Due to the fact that the wastewater discharge proportion can be obviously reduced, the production cost can be reduced and the environmental protection benefits and production benefits are more remarkable, and the antibiotic production process has better practicability and a popularization and application value.

Description

technical field [0001] The method belongs to the production process of antibiotics, and specifically relates to a clean extraction process of kitasamycin. Background technique [0002] In the prior art, the preparation of antibiotics by microbial fermentation is a relatively common and common production process, and its main production process includes: microbial fermentation, filtration, extraction and crystallization, refining, refining and other processes. Among them, solvent extraction is a commonly used method in the extraction process of antibiotics, and it is the most widely used. [0003] During the preparation of antibiotics, due to the needs of the production process, a large amount of high-concentration organic wastewater is often produced in the process of antibiotic separation, extraction, refining and purification, and these wastewaters have: high COD content (COD is generally 5000-80000mg / L Between), high SS concentration (500-25000mg / L), high chroma, large p...

AI Technical Summary

Problems solved by technology

[0003] During the preparation of antibiotics, due to the needs of the production process, a large amount of high-concentration organic wastewater is often produced in the process of antibiotic separation, extraction, refining and purification, and these wastewaters have: high COD content (COD is generally 5000-80000mg / L Between), high SS concentration (500-25000mg / L), high chroma, large pH fluctuation, intermittent discharge, etc., so the cost of harmless treatment is high, and the treatment is difficult. Therefore, it is extremely necessary to prepare by fermentation Properly improve the production process of antibiotics to reduce the cost of pollution control

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