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Assessment method of bone turnover rate of forty-year-old or older women

A conversion rate, female technology, applied in biological testing, material testing products, etc., can solve the problems of difficult application, poor consistency, and difficult application of bone turnover rate evaluation methods, and achieve effective and accurate diagnosis and curative effect observation. Effect

Active Publication Date: 2017-02-15
EPITOPE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The design defect of Roche osteocalcin in the cut-off value makes it difficult to apply clinically, and the consistency with other clinical diagnoses (such as bone density detection) is poor
Therefore, the existing bone turnover rate evaluation methods are difficult to be effectively applied in clinical practice.

Method used

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  • Assessment method of bone turnover rate of forty-year-old or older women
  • Assessment method of bone turnover rate of forty-year-old or older women
  • Assessment method of bone turnover rate of forty-year-old or older women

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Establishing the critical value: Taking 131 healthy women aged 30-50 in a certain area of ​​my country as the statistical object, the content of osteocalcin-N-terminal peptide in serum was determined by the osteocalcin-N-terminal peptide assay kit (enzyme-linked immunoassay) , to establish the critical value of serum osteocalcin for women over 40 years old in this area, take D 1 =P 5 ,D 2 =P 95 , the results are shown in Table 1. Note: P 5 ,P 95 is the percentile point.

[0028] Table 1

[0029]

[0030] In 33 cases of women over 40 years old in this area, the content of osteocalcin-N-terminal peptide in serum was measured with osteocalcin-N-terminal peptide assay kit (enzyme-linked immunoassay), compared with that measured by bone densitometry (DXA) The bone density, the results are shown in Table 2.

[0031] Table 2

[0032]

[0033]

[0034] After statistical analysis, the bone turnover rate evaluation results are shown in Table 3.

[0035] table 3

...

Embodiment 2

[0041] Establishing the critical value: Taking 128 healthy women aged 34-44 in a certain area of ​​my country as the statistical object, the content of osteocalcin-N-terminal peptide in serum was determined with the osteocalcin-N-terminal peptide assay kit (enzyme-linked immunoassay) , to establish the critical value of serum osteocalcin for women over 40 years old in this area, take D 1 =P 5 ,D 2 =P 95 , the results are shown in Table 4. Note: P 5 ,P 95 is the percentile point.

[0042] Table 4

[0043]

[0044] In 36 cases of women over 40 years old in this area, the content of osteocalcin-N-terminal peptide in serum was measured with osteocalcin-N-terminal peptide assay kit (enzyme-linked immunoassay), compared with bone densitometry (DXA) measurement The bone density, the results are shown in Table 5.

[0045] table 5

[0046]

[0047]

[0048] After statistical analysis, the bone turnover rate evaluation results are shown in Table 6.

[0049] Table 6

...

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Abstract

The invention provides an assessment method of a bone turnover rate of forty-year-old or older women. The method comprises the following steps that 1, the content of osteocalcin in serum is determined to obtain a measured value Cs, wherein the unit name is ng / mL; 2, statistics is performed on the content of osteocalcin in serum of local 30-50-year-old women to obtain a first critical value D1 and a second critical value D2, wherein the unit name is ng / mL, D1 is larger than or equal to 1 and smaller than or equal to 8, and D2 is larger than or equal to 12 and smaller than or equal to 28; 3, the measured value Cs is compared with the first critical value D1 and the second critical value D2, wherein when the Cs is smaller than the D1, it is determined that the bone turnover rate is low; when the Cs is larger than or equal to the D1 and smaller than the D2, it is determined that the bone turnover rate is normal; when the Cs is larger than or equal to the D2, it is determined that the bone turnover rate is high.

Description

technical field [0001] The invention relates to a method for evaluating bone turnover rate. Background technique [0002] Osteocalcin is a protein composed of 49 amino acids. It is derived from bone tissue, synthesized by osteoblasts and secreted into bone. It is the main component of non-collagenous protein in bone tissue. Its function is to regulate and maintain bone calcium, and it can basically reflect recent osteoblast activity and bone turnover. Case. [0003] Intact osteocalcin (amino acids 1-49) is unstable in peripheral blood, and the amino acid chain between carboxy-terminal 43 and 44 is easily hydrolyzed by proteases. The large fragment (amino acids 1-43) after cleavage contains 43 amino acids, which is called the N-terminal molecular fragment of osteocalcin or osteocalcin-N-terminal peptide (N-MID), and the osteocalcin-N-terminal peptide is in Relatively stable in peripheral blood. Therefore, in order to accurately determine the content of osteocalcin in seru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/48
CPCG01N33/48
Inventor 高平
Owner EPITOPE BIOTECH