Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Liquid composition for oral use and method for improving resilience to freezing thereof

A composition and restorative technology, which can be used in oral care, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of emulsification damage and freeze restorability, etc., and achieve suppression of irritation, excellent freeze restorability, good The effect of usability

Active Publication Date: 2017-02-22
LION CORP
View PDF10 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the composition of the emulsion, the water phase and the oil phase are in a mixed state through the emulsifier. Due to long-term storage, mechanical vibration, rapid temperature change, etc., the aggregation and coalescence of the emulsion are easy to occur. Emulsion destruction
The appearance of liquid preparations changes due to emulsification damage and causes quality problems. Although the above-mentioned patent documents also propose suggestions for improving storage stability, especially for those that have improved appearance recovery when frozen and thawed under low-temperature harsh conditions room
[0004] In addition, the above-mentioned patent documents do not mention the recoverability when frozen under low-temperature harsh conditions.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Liquid composition for oral use and method for improving resilience to freezing thereof
  • Liquid composition for oral use and method for improving resilience to freezing thereof
  • Liquid composition for oral use and method for improving resilience to freezing thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0056] A known method can be used for the preparation method of the emulsion.

[0057] For example, after mixing a specified amount of nonionic surfactant, polyol as a dispersant, and half an amount of water with a homogeneous mixer, add an oily component to form an emulsion, and finally add the remaining water to prepare O / W type emulsion. Thereafter, the prepared emulsion can be adjusted in average particle size using a high-pressure homogenizer.

[0058] In emulsification using a high-pressure homogenizer, the average particle size can be adjusted according to the difference in shear force. When the emulsified particles are micronized, the temporal stability is further improved. As the high-pressure homogenizer, it is possible to use a microfluidizer (manufactured by Microfluidic Technology International Co., Ltd.), a Gaulin homogenizer (manufactured by Rannie Gaulin), an ultimaizer (Altima). Machinery Co., Ltd. (Suginomasin Co., Ltd.), etc., are not limited to these mod...

Embodiment 1～18

[0100] [Examples 1-18, Comparative Examples 1-10]

[0101] The liquid oral compositions (mouthwashes) shown in Tables 1 to 4 were prepared by conventional methods, and the appearance stability (freeze recovery) during freezing and thawing, the refreshing feeling after use in the oral cavity, and the Is there any irritation. Moreover, about the liquid oral cavity composition which mixed isopropylmethylphenol shown in Table 3, 4, biofilm bactericidal ability was further evaluated by the following method. The results are collectively described in Tables 1-4.

[0102] In addition, the preparation method and composition of the emulsion used are as follows. The prepared emulsions A1 to A5 were mixed in the amounts shown in the table.

[0103]

[0104] An O / W type emulsion of the following composition was prepared by the following method. In addition, stirring using a homomixer uses a well-known high-pressure homogenizer (pressure condition 30-100 MPa), and the operation of pou...

Embodiment 19～24

[0183] The liquid oral compositions (mouthwashes) of Examples 19 to 24 shown in Table 5 were prepared in the same manner as above, and the appearance stability (freeze recovery) during freezing and thawing, and the stability after oral use were evaluated in the same manner as above. Refreshing feeling, irritating feeling during use, biofilm bactericidal ability, and whether there is a pungent taste during use are evaluated by the following methods. Moreover, the presence or absence of a pungent taste was evaluated similarly to Example 10 shown in Table 3, and the result is described in Table 5 together with the above-mentioned result.

[0184] In addition, the spices a to f used in Examples 19 to 24 all contain clove oil and thyme oil, and the contents of clove oil and thyme oil in the compositions of each example are shown in Table 5.

[0185] (5) Evaluation method for presence or absence of pungent taste during use

[0186] 10 panelists contained 10 mL of each liquid oral c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
The average particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
Login to View More

Abstract

Provided is a liquid composition for oral use with outstanding stability of external appearance when frozen and thawed (resilience to freezing), and which imparts an agreeable sensation when used, containing an emulsion (A) in which the oil component is a liquid at 25 DEG C, and N-acyl taurate (B), wherein the content of N-acyl taurate (B) is 0.2-0.8 mass%. Also provided is a method for improving the resilience to freezing of the liquid composition for oral use by including 0.2-0.8 mass % of N-acyl taurate (B) in a liquid composition for oral use containing the emulsion (A) in which the oil component is a liquid at 25 DEG C.

Description

technical field [0001] The present invention relates to a liquid oral composition mixed with an emulsion and a method for improving its freeze recovery. The liquid oral composition has excellent appearance stability (freeze recovery) when frozen and thawed, and can also impart good sense of use. Background technique [0002] Conventionally, as a technique for mixing an emulsion into a liquid oral composition, a technique of mixing a specific emulsion in order to suppress ethanol stimulation of an ethanol mixed preparation has been proposed (Patent Document 1: Japanese Patent Application Laid-Open No. 2005-179231 ) , Improve the retention of medicinal ingredients and improve the technology of action (Patent Document 2: Japanese Patent Laid-Open No. 2005-179231, Patent Document 3: Japanese Patent Laid-Open No. 11-335253, Patent Document 4: Japanese Patent No. Publication No. 5043588, Patent Document 5: Japanese Patent Laid-Open No. 2011-168506, Patent Document 6: Japanese Pat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K8/46A61K8/06A61K8/34A61K8/37A61K8/92A61Q11/00
CPCA61Q11/00A61K8/345A61K8/375A61K8/466A61K8/922A61K8/062A61K2800/21
Inventor 数野惠子赤羽康宏加藤妥治新仓祐司
Owner LION CORP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com