Liquid composition for oral use and method for improving resilience to freezing thereof

A composition and restorative technology, which can be used in oral care, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of emulsification damage and freeze restorability, etc., and achieve suppression of irritation, excellent freeze restorability, good The effect of usability

Active Publication Date: 2017-02-22
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the composition of the emulsion, the water phase and the oil phase are in a mixed state through the emulsifier. Due to long-term storage, mechanical vibration, rapid temperature change, etc., the aggregation and coalescence of the emulsion are easy to occur. Emulsion destruction
The appearance of liquid preparations changes due to emulsification damage and causes qua

Method used

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  • Liquid composition for oral use and method for improving resilience to freezing thereof
  • Liquid composition for oral use and method for improving resilience to freezing thereof
  • Liquid composition for oral use and method for improving resilience to freezing thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0056] A known method can be used for the preparation method of the emulsion.

[0057] For example, after mixing a predetermined amount of nonionic surfactant, polyol as a dispersant, and half of water with a homomixer, adding oily ingredients to form an emulsion, and finally adding the remaining water to prepare O / W Type emulsion. Thereafter, the prepared emulsion can be adjusted to the average particle size using a high-pressure homogenizer.

[0058] In emulsification using a high-pressure homogenizer, the average particle size can be adjusted according to the difference in shear force. If the emulsified particles are made into fine particles, the stability over time is further improved. The high-pressure homogenizer can use a microfluidizer (manufactured by Microfluidics International Co., Ltd.), a Gaulin homogenizer (manufactured by Rannie Gaulin Co., Ltd.), and ultimaizer (made by Rannie Gaulin). It is not limited to these models, as long as the principle is the same, any m...

Example

[0100] [Examples 1-18, Comparative Examples 1-10]

[0101] The liquid oral compositions (mouthwashes) shown in Tables 1 to 4 were prepared by a conventional method, and the appearance stability during freezing and thawing (freeze recovery), the refreshing feeling after use in the oral cavity, and the time of use were evaluated by the following methods Is there any stimulation? In addition, with respect to the liquid oral composition mixed with isopropyl methylphenol shown in Tables 3 and 4, the biofilm bactericidal ability was further evaluated by the following method. The results are shown in Tables 1 to 4.

[0102] In addition, the preparation method and composition of the emulsion used are as follows. The prepared emulsions A1 to A5 were mixed in the amounts shown in the table.

[0103]

[0104] The O / W emulsion of the following composition was prepared by the following method. In addition, a well-known high-pressure homogenizer (pressure condition 30-100 MPa) was used for sti...

Example

[0182] [Examples 19-24]

[0183] The liquid oral compositions (mouthwashes) of Examples 19 to 24 shown in Table 5 were prepared in the same manner as described above, and the appearance stability during freezing and thawing (freeze recovery) and the oral cavity after use were evaluated in the same manner as described above. Refreshing feeling, irritation during use, and biofilm sterilization ability were evaluated by the following method to evaluate whether there was acrid taste during use. In addition, the presence or absence of pungency in Example 10 shown in Table 3 was evaluated in the same manner, and the results are described in Table 5 together with the above results.

[0184] In addition, the fragrances a to f used in Examples 19-24 all contain clove oil and thyme oil. The content of clove oil and the content of thyme oil in the composition of each example are shown in Table 5.

[0185] (5) Evaluation method for spicy taste during use

[0186] Ten panelists put 10 mL of each ...

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Abstract

Provided is a liquid composition for oral use with outstanding stability of external appearance when frozen and thawed (resilience to freezing), and which imparts an agreeable sensation when used, containing an emulsion (A) in which the oil component is a liquid at 25 DEG C, and N-acyl taurate (B), wherein the content of N-acyl taurate (B) is 0.2-0.8 mass%. Also provided is a method for improving the resilience to freezing of the liquid composition for oral use by including 0.2-0.8 mass % of N-acyl taurate (B) in a liquid composition for oral use containing the emulsion (A) in which the oil component is a liquid at 25 DEG C.

Description

technical field [0001] The present invention relates to a liquid oral composition mixed with an emulsion and a method for improving its freeze recovery. The liquid oral composition has excellent appearance stability (freeze recovery) when frozen and thawed, and can also impart good sense of use. Background technique [0002] Conventionally, as a technique for mixing an emulsion into a liquid oral composition, a technique of mixing a specific emulsion in order to suppress ethanol stimulation of an ethanol mixed preparation has been proposed (Patent Document 1: Japanese Patent Application Laid-Open No. 2005-179231 ) , Improve the retention of medicinal ingredients and improve the technology of action (Patent Document 2: Japanese Patent Laid-Open No. 2005-179231, Patent Document 3: Japanese Patent Laid-Open No. 11-335253, Patent Document 4: Japanese Patent No. Publication No. 5043588, Patent Document 5: Japanese Patent Laid-Open No. 2011-168506, Patent Document 6: Japanese Pat...

Claims

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Application Information

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IPC IPC(8): A61K8/46A61K8/06A61K8/34A61K8/37A61K8/92A61Q11/00
CPCA61Q11/00A61K8/345A61K8/375A61K8/466A61K8/922A61K8/062A61K2800/21
Inventor 数野惠子赤羽康宏加藤妥治新仓祐司
Owner LION CORP
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