Targeting ligand-drug conjugate having cell endocytosis mediating function
A technology targeting ligands and conjugates, applied in the field of biomedical chemistry, can solve the problems of animal poisoning death, low curative effect, high toxicity, etc., and achieve the effects of enhancing drug efficacy, reducing drug toxicity, and ensuring stability
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[0027] The preparation method of the present invention is specifically described below in conjunction with the examples:
[0028] The present invention discloses a targeting ligand-drug conjugate with cell endocytosis mediating function. The drug conjugate includes a drug molecule and a linker coupled to the drug molecule. The drug conjugate The body also includes molecules with endocytosis mediation and ligands that specifically bind to cell surface receptors. The ligands can be polypeptides or small molecule ligands, but there are also some special ligands that also have endocytosis. Function and target receptor binding function (such as folic acid, P11, P12 polypeptides). The endocytosis mediating molecule and the ligand can be coupled with each other, then coupled with a drug molecule or a linker to form a drug conjugate, or separately coupled with one of the drug molecule and the linker to form a drug conjugate.
[0029] Wherein, the molecule with endocytosis mediating e...
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