Iron-based magnetic nano-particles regionally modified intraocular lens and preparation method and application thereof

Abstract

The invention provides an iron-based magnetic nano-particles regionally modified intraocular lens and a preparation method and application thereof. The intraocular lens comprises an intraocular lens body and iron-based magnetic nano-particles for coating of a connection layer, which is connected to the equatorial region of the intraocular lens body. The intraocular lens is obtained through hydroxyl modification of the equatorial region of the intraocular lens body and chemical bonding of the iron-based magnetic nano-particles. The intraocular lens has no influence on optical performance of the intraocular lens body, has good biocompatibility, can controllably kill lens epithelial cells at real time, and can effectively reduce recurrence rate of cataract so as to solve the great clinic problem of after-cataract. The intraocular lens enables chemicals to selectively act on the lens epithelial cells rather than damage other intraocular tissues. The invention provides a new idea, a new approach and a new method for prevention of after-cataract.

Description

technical field

[0001] The invention belongs to the technical field of intraocular lens, relates to an intraocular lens and its preparation method and application, in particular to an iron-based magnetic nanoparticle domain-modified intraocular lens for preventing and / or treating post-cataract and its preparation method and use. Background technique

[0002] Cataract lens opacity, commonly known as cataract, with the aging of the global population, the incidence rate and the total number of affected population are increasing. Cataract has become the world's first blinding eye disease. Among the 40-45 million blind people in the world, 46% of them are blinded by cataract. At present, there are 6.7 million cataract patients in my country, and about 1.3 million new cataract-blind people are added every year. Cataracts cause blurred vision or even blindness, causing great inconvenience and pain to cataract patients. Surgical removal of the cataract lens and intraocular intraoc...

Examples

Embodiment 1

[0063] an intraocular lens such as figure 1 shown. The intraocular lens includes an intraocular lens body and ferric oxide nanoparticles coated with a silicon dioxide layer on the surface, and the silicon dioxide layer is bonded to the equatorial part of the intraocular lens body; the particles of the ferric oxide nanoparticles are The diameter is 8nm; the thickness of the silicon dioxide layer is 22nm; the material of the intraocular lens body is hydrophilic acrylate polymer.

[0064] The preparation method of described intraocular lens comprises the steps:

[0065] (1) Cover the surface outside the equatorial part of the intraocular lens body with 3M adhesive tape, and use plasma surface treatment to modify the equatorial part of the intraocular lens body with hydroxyl groups, wherein the discharge gas source for the plasma surface treatment is argon , the discharge power is 29.6W, and the plasma treatment time is 5min;

[0066] (2) Soak the intraocular lens body with the...

Embodiment 2

[0092] an intraocular lens such as figure 1 shown. The intraocular lens includes an intraocular lens body and ferric oxide nanoparticles coated with a silicon dioxide layer on the surface, and the silicon dioxide layer is bonded to the equatorial part of the intraocular lens body; the particles of the ferric oxide nanoparticles are The diameter is 3nm; the thickness of the silicon dioxide layer is 5nm; the material of the intraocular lens body is silicone gel.

[0093] The preparation method of described intraocular lens comprises the steps:

[0094] (1) Cover the surface outside the equatorial part of the intraocular lens body with 3M tape, and use plasma surface treatment to modify the equatorial part of the intraocular lens body with hydroxyl groups, wherein the discharge gas source of the plasma surface treatment is nitrogen, The discharge power is 14W, and the plasma treatment time is 600min;

[0095] (2) Soak the intraocular lens body modified with hydroxyl groups at ...

Embodiment 3

[0101] an intraocular lens such as figure 1 shown. The intraocular lens includes an intraocular lens body and ferric oxide nanoparticles coated with a silicon dioxide layer on the surface, and the silicon dioxide layer is bonded to the equatorial part of the intraocular lens body; the particles of the ferric oxide nanoparticles are The diameter of the silicon dioxide layer is 30nm, and the thickness of the silicon dioxide layer is 25nm; the material of the intraocular lens body is hydrogel.

[0102] The preparation method of described intraocular lens comprises the steps:

[0103] (1) Cover the surface outside the equatorial part of the intraocular lens body with 3M adhesive tape, and use plasma surface treatment to modify the equatorial part of the intraocular lens body with hydroxyl groups, wherein the discharge gas source of the plasma surface treatment is volume ratio Nitrogen and oxygen are 1:1, the discharge power is 200W, and the plasma treatment time is 1min;

[010...

technical field

[0001] The invention belongs to the technical field of intraocular lens, relates to an intraocular lens and its preparation method and application, in particular to an iron-based magnetic nanoparticle domain-modified intraocular lens for preventing and / or treating post-cataract and its preparation method and use. Background technique

[0002] Cataract lens opacity, commonly known as cataract, with the aging of the global population, the incidence rate and the total number of affected population are increasing. Cataract has become the world's first blinding eye disease. Among the 40-45 million blind people in the world, 46% of them are blinded by cataract. At present, there are 6.7 million cataract patients in my country, and about 1.3 million new cataract-blind people are added every year. Cataracts cause blurred vision or even blindness, causing great inconvenience and pain to cataract patients. Surgical removal of the cataract lens and intraocular intraoc...

Examples

Embodiment 1

[0063] an intraocular lens such as figure 1 shown. The intraocular lens includes an intraocular lens body and ferric oxide nanoparticles coated with a silicon dioxide layer on the surface, and the silicon dioxide layer is bonded to the equatorial part of the intraocular lens body; the particles of the ferric oxide nanoparticles are The diameter is 8nm; the thickness of the silicon dioxide layer is 22nm; the material of the intraocular lens body is hydrophilic acrylate polymer.

[0064] The preparation method of described intraocular lens comprises the steps:

[0065] (1) Cover the surface outside the equatorial part of the intraocular lens body with 3M adhesive tape, and use plasma surface treatment to modify the equatorial part of the intraocular lens body with hydroxyl groups, wherein the discharge gas source for the plasma surface treatment is argon , the discharge power is 29.6W, and the plasma treatment time is 5min;

[0066] (2) Soak the intraocular lens body with the...

Embodiment 2

[0092] an intraocular lens such as figure 1 shown. The intraocular lens includes an intraocular lens body and ferric oxide nanoparticles coated with a silicon dioxide layer on the surface, and the silicon dioxide layer is bonded to the equatorial part of the intraocular lens body; the particles of the ferric oxide nanoparticles are The diameter is 3nm; the thickness of the silicon dioxide layer is 5nm; the material of the intraocular lens body is silicone gel.

[0093] The preparation method of described intraocular lens comprises the steps:

[0094] (1) Cover the surface outside the equatorial part of the intraocular lens body with 3M tape, and use plasma surface treatment to modify the equatorial part of the intraocular lens body with hydroxyl groups, wherein the discharge gas source of the plasma surface treatment is nitrogen, The discharge power is 14W, and the plasma treatment time is 600min;

[0095] (2) Soak the intraocular lens body modified with hydroxyl groups at ...

Embodiment 3

[0101] an intraocular lens such as figure 1 shown. The intraocular lens includes an intraocular lens body and ferric oxide nanoparticles coated with a silicon dioxide layer on the surface, and the silicon dioxide layer is bonded to the equatorial part of the intraocular lens body; the particles of the ferric oxide nanoparticles are The diameter of the silicon dioxide layer is 30nm, and the thickness of the silicon dioxide layer is 25nm; the material of the intraocular lens body is hydrogel.

[0102] The preparation method of described intraocular lens comprises the steps:

[0103] (1) Cover the surface outside the equatorial part of the intraocular lens body with 3M adhesive tape, and use plasma surface treatment to modify the equatorial part of the intraocular lens body with hydroxyl groups, wherein the discharge gas source of the plasma surface treatment is volume ratio Nitrogen and oxygen are 1:1, the discharge power is 200W, and the plasma treatment time is 1min;

[010...

Images