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Method and device for acquiring gene mutation site corresponding to psychology and spirit

A technology of genetic sites and mutation sites, which is applied in the field of acquisition of mutation sites, can solve the problems of limited number of mutation sites, deviation of prediction results, and inability to simultaneously determine the mutation status of the gene mutation site to be tested, etc.

Inactive Publication Date: 2017-03-22
成都鑫云解码科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The existing determination of mutations of psychological and spiritual gene sites is usually to obtain the base mutations of a gene site at a specified position of the gene to be tested by chemical means, and the number of mutation sites obtained by this acquisition method is limited , usually only the mutation of a certain base or a few bases can be obtained, and the mutation of as many mutation sites as possible in the genes corresponding to psychology and spirit in the gene to be tested cannot be determined at the same time, so that the follow-up can be combined with other information There may be large deviations in the prediction results of the prevalence of mental and psychiatric diseases

Method used

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  • Method and device for acquiring gene mutation site corresponding to psychology and spirit
  • Method and device for acquiring gene mutation site corresponding to psychology and spirit
  • Method and device for acquiring gene mutation site corresponding to psychology and spirit

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no. 1 example

[0032] The embodiment of the present application provides a method for obtaining mutation sites of genes corresponding to psychology and spirit, which is used to obtain the base mutation status of mutation sites of genes related to psychology and spirit in the gene to be tested. See figure 2 , the method includes:

[0033] Step S110: Compare multiple short sequences of the gene to be tested with the reference genome to obtain preliminary mutation site information of the gene to be tested, and the preliminary mutation site information includes mutation bases of multiple preliminary mutation sites And the location information of each preliminary mutation site.

[0034] First, multiple short sequences of the gene to be tested are obtained, which can be output through a second-generation sequencing platform. Align the short sequence of the gene to be tested with the reference genome. For example, if the gene to be tested is a human gene, the reference genome is a human referen...

no. 2 example

[0108] This embodiment provides a device 200 for obtaining mutation sites of genes corresponding to psychology and spirit. Please refer to Figure 4 , the device 200 includes:

[0109] The comparison module 210 is used to compare the data of multiple short sequences of the gene to be tested with the reference genome to obtain preliminary variation site information of the gene to be tested, and the preliminary variation site information includes a plurality of preliminary variation sites The mutated bases and the position information of each preliminary mutated site.

[0110] The filtering module 220 is used to delete the variable sites that do not meet the preset retention conditions among the multiple preliminary variable sites according to the preliminary variable site information, and delete the variable sites in the gene to be tested obtained after deletion as the detection point.

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Abstract

The invention provides a method and device for acquiring a gene mutation site corresponding to psychology and spirit, and relates to the technical field of biological information. The method comprises: performing data comparison on multiple short sequences of a to-be-tested gene and a reference genome, thereby acquiring initial mutation site information of the to-be-tested gene; according to the initial mutation site information, canceling mutation sites, which do not meet preset preservation conditions, in multiple initial mutation sites, and using a mutation site, which is obtained after canceling, of the to-be-tested gene as a to-be-tested site; comparing the to-be-tested site with the multiple mutation sites of the gene corresponding to the psychology and spirit in a psychology and spirit gene pool; and when the to-be-tested site has a mutation site having the same position in the psychology and spirit gene pool and the same mutant base, acquiring the mutation situation of a gene site corresponding to the psychology and spirit in the to-be-tested gene. According to the method and device for acquiring the gene mutation site corresponding to the psychology and spirit, the mutation situation of the multiple mutation sites corresponding to the psychology and spirit in the mutation sites of the to-be-tested gene can be obtained.

Description

technical field [0001] The present application relates to the field of biological information technology, in particular, to a method and device for obtaining mutation sites of genes corresponding to psychology and spirit. Background technique [0002] With the development and maturity of medicine, genomics and high-throughput sequencing technology, precision medicine (Precision Medicine) is also applied in countries around the world, becoming a new medical model. Precision medicine is a medical method for disease prevention and treatment that takes into account the differences in personal genes, environment and living habits, and formulates personalized and precise medical and health management plans based on each person's genetic information. [0003] The genetic background of each person is different. In this process, it is necessary to determine the mutation of each person's genome or some genes associated with the corresponding organ or location, so that further analysis...

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Application Information

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IPC IPC(8): G06F19/18
CPCG16B20/00
Inventor 范振鑫何苗
Owner 成都鑫云解码科技有限公司