Unlock instant, AI-driven research and patent intelligence for your innovation.

Method and device for acquiring mutation site of corresponding gene of urogenital system

A reproductive system and gene locus technology, applied in the field of mutation site acquisition, can solve the problems of inability to simultaneously determine mutation status, limited number of mutation sites, biased prediction results, etc.

Inactive Publication Date: 2017-03-15
成都鑫云解码科技有限公司
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The existing determination of the mutation of the gene site in the urinary and reproductive system is usually to obtain the base mutation of the gene site at a specified position of the gene to be tested by chemical means. The number of mutation sites obtained by this method is Limited, usually only one or a few base mutations can be obtained, and the mutations of as many mutation sites as possible in the genes corresponding to the urinary and reproductive systems in the gene to be tested cannot be determined at the same time, so that the subsequent combination There may be large deviations in the prediction results of other information on the prevalence of urinary and reproductive diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method and device for acquiring mutation site of corresponding gene of urogenital system
  • Method and device for acquiring mutation site of corresponding gene of urogenital system
  • Method and device for acquiring mutation site of corresponding gene of urogenital system

Examples

Experimental program
Comparison scheme
Effect test

no. 1 example

[0032] The embodiment of the present application provides a method for obtaining mutation sites of genes corresponding to the urinary and reproductive system, which is used to obtain the base mutation status of the mutation sites of genes related to the urinary and reproductive system in the gene to be tested. See figure 2 , the method includes:

[0033] Step S110: Compare multiple short sequences of the gene to be tested with the reference genome to obtain preliminary mutation site information of the gene to be tested, and the preliminary mutation site information includes mutation bases of multiple preliminary mutation sites And the position information of each preliminary mutation site.

[0034] First, multiple short sequences of the gene to be tested are obtained, which can be output through a second-generation sequencing platform. Align the short sequence of the gene to be tested with the reference genome. For example, if the gene to be tested is a human gene, the ref...

no. 2 example

[0108] This embodiment provides a device 200 for acquiring mutation sites of genes corresponding to the urinary and reproductive systems. Please refer to Figure 4 , the device 200 includes:

[0109] The comparison module 210 is used to compare the data of multiple short sequences of the gene to be tested with the reference genome to obtain preliminary variation site information of the gene to be tested, and the preliminary variation site information includes a plurality of preliminary variation sites The mutated bases and the position information of each preliminary mutated site.

[0110] The filtering module 220 is used to delete the variable sites that do not meet the preset retention conditions among the multiple preliminary variable sites according to the preliminary variable site information, and delete the variable sites in the gene to be tested obtained after deletion as the detection point.

[0111] The comparison module 230 is used to compare the site to be tested ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a method and device for acquiring a mutation site of a corresponding gene of a urogenital system and relates to the technical field of biological information. The method comprises the following steps: carrying out data comparison on multiple short sequences of a to-be-detected gene with a reference genome, and obtaining preliminary variation site information of the to-be-detected gene; according to the preliminary variation site information, deleting variation sites which do not meet preset reservation conditions in multiple preliminary variation sites, and obtaining a to-be-detected site; comparing the to-be-detected site with multiple variation sites of the corresponding gene of the urogenital system in a gene bank of the urogenital system; and when a variation site which is the same in position and mutation bases in the gene bank of the urogenital system exists in the to-be-detected site, obtaining a site mutation condition of the corresponding gene of the urogenital system in the to-be-detected gene. The method and device which are provided by the invention have the advantage that mutation conditions of multiple variation sites related to the urogenital system in the variation sites in the to-be-detected gene can be obtained.

Description

technical field [0001] The present application relates to the field of biological information technology, in particular, to a method and device for acquiring mutation sites of genes corresponding to the urinary and reproductive systems. Background technique [0002] With the development and maturity of medicine, genomics and high-throughput sequencing technology, precision medicine (Precision Medicine) is also applied in countries around the world, becoming a new medical model. Precision medicine is a medical method for disease prevention and treatment that takes into account the differences in personal genes, environment and living habits, and formulates personalized and precise medical and health management plans based on each person's genetic information. [0003] The genetic background of each person is different. In this process, it is necessary to determine the mutation of each person's genome or some genes associated with the corresponding organ or location, so that f...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G06F19/18
CPCG16B20/00
Inventor 范振鑫郭涛芮曦
Owner 成都鑫云解码科技有限公司