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Application of streptococcus sanguis protein to preparation of drugs inhibiting candida albicans

A technology for Candida albicans and Streptococcus sanguis, applied in the field of Streptococcus sanguis protein, can solve the problems of high toxicity and side effects, easy to produce drug-resistant strains, etc.

Active Publication Date: 2017-04-26
马晟利
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Problems solved by technology

[0003] The present invention provides an application of Streptococcus sanguis protein in the preparation of drugs for inhibiting Candida albicans, so as to solve the problem of large toxic and side effects and easy to treat the existing chemically synthesized drugs such as azoles and polyenes in the treatment of Candida infection. The problem of developing drug-resistant strains

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  • Application of streptococcus sanguis protein to preparation of drugs inhibiting candida albicans
  • Application of streptococcus sanguis protein to preparation of drugs inhibiting candida albicans
  • Application of streptococcus sanguis protein to preparation of drugs inhibiting candida albicans

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[0029] 1. Extraction and effect determination method

[0030] 1.1 Preparation process of Streptococcus sanguis protein extract

[0031] Add the purified and identified Streptococcus sanguis (the standard strain of Streptococcus sanguis ATCC10556 was purchased from the Key Laboratory of Oral Biomedical Engineering, Ministry of Health, West China College of Stomatology, Sichuan, and this standard strain belongs to the public and can be purchased through normal commercial channels) into 8.5L In the BHI (ox heart and brain infusion) liquid culture medium (OXOID, England), under anaerobic conditions at 37°C, after constant temperature and static culture for 48 hours, immediately place the suspension of Streptococcus sanguis bacteria at 4°C, 12000r / Centrifuge for 30 minutes in a low-temperature high-speed centrifuge for 30 minutes, collect the bacterial precipitate, dissolve it with 1×PBS (phosphate buffer saline), and centrifuge again. Repeat the above lysis centrifugation proces...

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Abstract

The invention discloses application of streptococcus sanguis protein to preparation of drugs inhibiting candida albicans and relates to application of streptococcus sanguis protein on drugs. The problems that azole type and polyenoid type chemical synthesis drugs are large in toxic and side effects in treatment of candidal infection and drug-resistant strain bacteria can be generated easily are solved. The streptococcus sanguis mixed protein is used for preparing the drugs inhibiting the candida albicans. The streptococcus sanguis protein makes the cell morphology of the candida albicans change and the membrane permeability increased, the adhesive effect and the gemmation of the candida albicans are inhibited, and generation of hyphae is interdicted. According to the application, streptococcus sanguis extracts are used for funguses antagonism, and it is verified that the streptococcus sanguis extracts have a high inhibiting effect on funguses.

Description

technical field [0001] The invention relates to a Streptococcus sanguis protein, in particular to the application of the Streptococcus sanguis protein in medicine. Background technique [0002] Fungi widely exist in nature and are the number one killer of human health. They can attack different parts of the human body to cause diseases, such as the oral cavity, upper respiratory tract, intestinal tract, vagina, skin, etc. The fatality rate of deep fungal infections is as high as 70% to 80%. In recent years, with the widespread clinical application of drugs such as antibiotics, glucocorticoids, and immune preparations, and the widespread development of various medical technologies such as radiotherapy, peritoneal dialysis, and surgery, the population of immunocompromised patients is expanding day by day. The number of fungal infections is increasing day by day, causing the infection rate of candida to rise continuously, and the clinical harm is relatively strong. However, t...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02A61K35/74A61P31/10
CPCA61K35/74A61K38/02A61K2300/00
Inventor 马晟利孙辉李惠葛文玉
Owner 马晟利
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