Early prediction marker for gestational diabetes mellitus and detection method thereof
A technology of markers and diabetes, which is applied in the direction of biological testing, material inspection products, etc., can solve the problems of not being able to predict markers of gestational diabetes, and achieve the effects of avoiding adverse effects, high prediction accuracy, and simple operation
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Embodiment 1
[0021] The serum samples of target 1 were collected at 12-16 weeks of pregnancy, and the serum samples of patients with gestational diabetes mellitus and healthy controls were compared and analyzed by high-throughput proteomics method and enzyme-linked immunosorbent technology. The results were obtained: Compared with the serum of healthy pregnant women, 33 serum differential proteins were obtained in the serum of patients with gestational diabetes, of which 14 expressed proteins were up-regulated and 19 expressed proteins were down-regulated, see Table 1 below for details.
[0022] Table 1 Comparison table of serum differential protein between target 1 and healthy pregnant women in early pregnancy (12-16 weeks)
[0023]
[0024]
Embodiment 2
[0026] The serum samples of target 2 were collected at 12-16 weeks of gestation, and the serum samples of patients with gestational diabetes mellitus and healthy controls were compared and analyzed by high-throughput proteomics method. The results were obtained: Compared with the serum of healthy pregnant women, 3 serum differential proteins were obtained in the serum of patients with gestational diabetes mellitus, of which 2 expressed proteins were up-regulated and 1 expressed protein was down-regulated, as shown in Table 2 below.
[0027] Table 2 Comparison table of serum differential protein between target 2 and healthy pregnant women in early pregnancy (12-16 weeks)
[0028]
Embodiment 3
[0030] The serum samples of target 3 were collected at 12-16 weeks of pregnancy, and the serum samples of patients with gestational diabetes mellitus and healthy controls were compared and analyzed by enzyme-linked immunosorbent immunoassay and protein chip technology. The results were obtained: Compared with the serum of healthy pregnant women, 4 serum differential proteins were obtained in the serum of patients with gestational diabetes mellitus, of which 2 expressed proteins were up-regulated and 2 expressed proteins were down-regulated, see Table 3 below for details.
[0031] Table 3 Comparison Table of Serum Difference Protein between Target 3 and Healthy Pregnant Women in Early Pregnancy (12-16 Weeks)
[0032]
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