Compound ks513, compositions comprising the same and uses thereof
A compound and composition technology, which can be used in pharmaceutical combinations, medical preparations containing active ingredients, applications, etc., can solve problems such as no anti-inflammatory activity, anti-allergic activity, anti-asthma activity, and anti-COPD activity.
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[0084] The following reference examples, examples and experimental examples are intended to further illustrate the present invention without limiting its scope.
reference example 1
[0085] Reference example 1. Analyzer
[0086] Melting point was measured by melting point measuring device (Koflermicrohostage) (without correction); optical rotation was measured by Jasco P-1020 polarimeter; UV data was measured by UV-VIS 2450 spectrometer; FT-IR spectrum was measured by Jasco FT / IR-4200 ; NMR spectra were determined by Varian UNITY 400MHz FT-NMR spectrometer using TMS as internal standard; HRESIMS was determined by Waters Q-TOF Premier spectrometer; and HPLC was performed by Gilson HPLC using UV / VIS-155 detector and pump 305 in the experiments analyze.
Embodiment 1
[0087] Example 1: Preparation of new compound (KS513) from Pseudolysimachion rotundum var. subintegrum
[0088] 1-1. Preparation of Crude Extract
[0089] 4.0 kg of dried Pseudolysimachion rotundum var. subintegrum (according to GAP, KRIBB0020697, KRIBB's plant extract bank, cultivated in Soi-myeon Eumseong-gun Chungcheongbuk-do, 244, Korea; Taejeon, Korea) was cut into small pieces, and mixed with 10 L methanol mixture. The mixture was stirred at room temperature for 24 hours and extracted twice at 78° C. under reflux for 12 hours to collect the filtrate. Filter the extract with filter paper to remove residue. The collected filtrate was concentrated by a rotary evaporator (EYELA, N-2100, Japan) at 55°C-65°C under reduced pressure, and dried with a freeze dryer to obtain 397.4 g of dried crude extract.
[0090] 1-2. Preparation of purified extract
[0091] 200 g of the dried crude extract was dissolved in a mixed solvent (25% MeOH-water) and further purified by using prepa...
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