22 results about "Hydroxybenzoates" patented technology

The present application provides a reversible thermochromic microcapsule pigment which is easily changed to a colored state from a colorless state by heating at a temperature in a living environment temperature range or a temperature close to a daily life temperature, and is sensitively recovered to the colorless state again. The reversible thermochromic microcapsule pigment of the present application is formed by enclosing a reversible thermochromic composition in a microcapsule, the reversible thermochromic composition comprising (A) an electron-donating colored organic compound, (B) a 4-hydroxybenzoic acid ester compound represented by the following general formula (1) as an electron-accepting compound (in the formula, R represents a linear or branched alkyl group having 12 to 22 carbon atoms), (C) a chain hydrocarbon compound or the like as a reaction medium in which reversible electron transfer reactions based on the above (A) and (B) occur, (D) a linear dibasic acid compound having 3 to 22 carbon atoms, and (E) an aromatic hydrocarbon compound or the like having a melting point of 50°C or higher.

Cosmetic composition comprising(i) bemotrizinol (bis-ethylhexyloxyphenol methoxyphenyl triazine),(ii) a water-soluble organic UV filter or a salt thereof,(iii) at least one inorganic UV filter,wherein the cosmetic composition is free of the UV filters from the group consisting of hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI diethylamino hydroxybenzoyl hexyl benzoate), 2,2′-Methylenbis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol](bisoctrizole), 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate (INCI Homosalate), polysilicone-15, and 2-hydroxy-4-methoxybenzophenone (INCI benzophenone-3) and a method for increasing the water resistance of a cosmetic composition comprising bis-ethylhexyloxyphenol methoxyphenyl triazine (bemotrizinol), zinc oxide, and titanium dioxide comprising the step of adding a water-soluble organic UV filter or a salt thereof to the cosmetic composition.

Provided is a stabilized polymer composition comprising a silyl-modified polymer material to be stabilized and a stabilizer composition comprising at least one hindered phenol antioxidant and at least one hindered hydroxybenzoate; and optionally at least one hindered amine light stabilizer, and / or at least one UV absorber and / or at least one moisture scavenger making it possible to enhance the thermal stability of the silyl-modified polymers based formulations, for applications such as sealants, coatings and adhesives. The present invention also relates to a use of said stabilizer composition as stabilizer in sealants, adhesives and / or coatings based on at least one silyl-modified polymer and to a method of improving thermal stability of silyl-modified polymer based adhesives, sealants and / or coatings comprising adding of at least one said stabilizer composition to a stabilized polymer composition comprising a silyl-modified polymer.

To provide an eye drop-type eyewash composition and the like having excellent antiseptic properties.SOLUTION: The eye drop-type eyewash composition contains 0.005-0.03 w / v% of allantoin and does not contain any antiseptic agents selected from quaternary ammonium salt-based antiseptic agents, p-hydroxybenzoic acid esters, chlorobutanol, and sorbic acid.SELECTED DRAWING: None

To provide an adhesive layer which has good adhesive force to various adherends even in the case of a thin film and little change in adhesive force with time.SOLUTION: There is provided an adhesive layer obtained by crosslinking an adhesive composition comprising a polyester-based resin (i) having structural moieties derived from polycarboxylic acids (a) and a structural moiety derived from a polyol component (b), wherein the adhesive layer has a thickness of 18 μm or less and contains 60 mol% or more of structural moieties derived from aliphatic dicarboxylic acids (a1) having 8 or less carbon atoms of the structural moieties derived from the polycarboxylic acids (a).SELECTED DRAWING: None

This invention discloses a sustainable fuel digital tracer system, comprising at least two chemical tracers added at predetermined concentration ratios, which constitute a unique identification code for each batch of fuel. The at least two chemical tracers are selected from methoxyacrylate compounds, or at least one is selected from methoxyacrylate compounds, with the remainder selected from at least one of benzoate compounds, p-hydroxybenzoate compounds, and sorbate compounds. The tracers of this invention are all pure organic small molecules free of metals and halogens, achieving "harmless passage" to the engine after combustion. This system can accurately decode fuel at low concentrations, possesses excellent cross-fuel versatility, and cleverly meets the shelf-life requirements of marine fuels, achieving low-cost, high-precision fuel authenticity verification and accurate traceability.

Disclosed is a thickener dispersion including a thickener including at least one among carboxymethyl cellulose and metal salt of the carboxymethyl cellulose, a change-over-time inhibitor, and an aqueous solvent. The change-over-time inhibitor includes at least one selected from the group consisting of phenoxyethanol, sodium azide, paraben, formaldehyde, 5-chloro-2-methyl-4-isothiazolin-3-one, sodium benzoate, ethylhexylglycerin, and 1,2-hexanediol. The thickener is included in an amount of 0.05 wt % to 3.5 wt % in the thickener dispersion, and the change-over-time inhibitor is included in an amount of 0.05 wt % to 3.0 wt % in the thickener dispersion.

The present invention pertains to a formulation designed for the treatment of acne, possessing potent antibacterial activity The invention additionally outlines a method for preparing this formulation tailored for acne treatment. The formulation, presented as a topical gel, incorporates a synergistic blend of doxycycline and riboflavin, along with key components such as carbopol, emollient, penetration enhancer, parabens, distilled water, and triethanolamine. Utilizing a 32 factorial design approach, the formulation is statistically optimized to achieve optimal characteristics. Notably, the formulation demonstrates a harmonious interaction between doxycycline and riboflavin, resulting in enhanced antibacterial efficacy. Furthermore, the formulation exhibits proven nonirritant properties and maintains stability during storage.

The invention relates to a poly (aromatic ester-ether)-based biodegradable material polyester and a preparation method thereof. The method comprises the following steps: firstly, taking 3-allyl-4-hydroxybenzoate and cyclohexyl-1, 4-dimethyl alcohol monovinyl ether as monomers, and synthesizing poly (aromatic ester-ether) dihydric alcohol through emulsion polymerization; and carrying out esterification and polycondensation on the polyester, organic dibasic acid, 2, 4-methyl dihydroxybenzoate, a polyfunctional cross-linking agent and a stabilizer under the action of a catalyst to prepare the novel poly (aromatic ester-ether)-based biodegradable material polyester. According to the method, traditional 1, 4-butanediol is replaced with methyl 2, 4-dihydroxybenzoate, so that cyclization side reaction is effectively inhibited, tetrahydrofuran is prevented from being generated, and consistency and stability of product quality are guaranteed. The obtained polyester material has excellent biodegradability and mechanical tensile property, and is suitable for plastic products such as mulching films, packaging bags and the like which need to be completely degraded and have enough mechanical strength requirements.

The invention belongs to the technical field of medicines, and particularly relates to application of UCM05 (naphthalene-1, 3-diyl di (3, 4, 5-trihydroxy benzoate) with the molecular formula of C24H16O10, the molecular weight of 464.38 and the CAS number of 1094451-90-7) in the aspect of inhibiting growth of gastrointestinal tumors. Through cell proliferation and clone formation experiments, it is verified for the first time that UCM05 can effectively inhibit growth of human esophageal cancer, colorectal cancer and gastric cancer cells. In a 4-nitroquinoline-1-oxide induced esophageal cancer Scyl2 knockout mouse model, the UCM05 is proved to be capable of remarkably inhibiting the progress of the esophageal cancer, and the inhibiting effect of the UCM05 is weakened under the SCYL2 gene knockout condition. The invention provides a new candidate drug and basis for clinical research, treatment and prevention of digestive tract tumors.

To provide an eyewash composition having excellent antiseptic properties.SOLUTION: The eyewash composition contains allantoin and polyoxyethylene hardened castor oil, but does not contain any antiseptic agents selected from quaternary ammonium salt-based antiseptic agents, p-hydroxybenzoic acid esters, chlorobutanol, and sorbic acid.SELECTED DRAWING: None

To provide a formulation including components contributing to epidermal and dermal health.SOLUTION: The present invention provides a bacterium belonging to Staphylococcus epidermidis species, strain BG-S174, deposited as accession number NITE P-04075, which enhances expression of the ceramide synthase 3 gene and also enhances expression of the hyaluronan synthase 3 gene. A formulation prepared using this strain can enhance expression of the ceramide synthase 3 gene and also enhance expression of the hyaluronan synthase 3 gene.SELECTED DRAWING: None

To provide a topical composition which contains ceramide 2 and paraben and which can suppress separation.SOLUTION: Provided is a topical composition comprising: (A) ceramide 2; (B) paraben; and (C) a heparinoid.SELECTED DRAWING: None

A carrot extract or a fraction thereof of the present invention, particularly cis-4-hydroxycinnamyl 4-hydroxybenzoate derived therefrom, has anti-arthritis, anti-inflammatory, antioxidant, anti-aging, or anticancer effects, and thus can be effectively used in a pharmaceutical composition, a functional health food composition, or a treatment method. In addition, the present invention relates to 3-(4-Hydroxyphenyl)propyl 4-hydroxybenzoate derived from a novel carrot-derived compound cis-4-hydroxycinnamyl 4-hydroxybenzoate, and an effective method for preparing same.

The present invention relates to a solid oral pharmaceutical composition that includes: (a) an active pharmaceutical ingredient; (b) a nitrosamine inhibitor that includes linear or branched C1-C10 alkyl 3,4,5-trihydroxybenzoate; and (c) a pharmaceutically acceptable excipient. At least one of: (i) the active pharmaceutical ingredient includes at least one covalently bonded amine group that is subject to conversion to nitrosamine; or (ii) the solid oral pharmaceutical composition includes at least one amine, that is other than the amine group covalently bonded to / within the active pharmaceutical ingredient, and which is subject to conversion to nitrosamine. The nitrosamine inhibitor is present in an amount at least sufficient to reduce the amount of nitrosamine formed in the solid oral pharmaceutical composition, compared to the amount of nitrosamine formed in a comparative solid oral pharmaceutical composition that is free of the nitrosamine inhibitor.

An agent for three-dimensional (3D) printing includes at least 3 wt % active, based on a total weight of the agent, of a paraben selected from the group consisting of methyl paraben, ethyl paraben, propyl paraben, butyl paraben, isopropyl paraben, isobutyl paraben, heptyl paraben, benzyl paraben, salts thereof, and combinations thereof; and an aqueous vehicle. The aqueous vehicle includes up to 85 wt % active, based on the total weight of the agent, of a co-solvent package including at least one co-solvent present in an amount sufficient to increase a solubility of the paraben in the aqueous vehicle; and a balance of water.

The present invention provides a process for preparing an overbased alkaline earth metal alkylhydroxybenzoate, the process comprising the steps of reacting an alkylphenol with an alkali metal hydroxide in the presence of a diluent oil to produce an alkali metal alkylphenate; carboxylating the alkali metal alkylphenolate with carbon dioxide; acidifying the alkali metal alkylhydroxybenzoic acid salt to produce an alkylhydroxybenzoic acid; adding methanesulfonic acid, a monohydric alcohol, water, and an alkaline earth metal base to the alkylhydroxybenzoic acid to form an alkaline earth metal alkylhydroxybenzoate and at least one alkaline earth metal sulfonate; and reacting the alkaline earth metal alkylhydroxybenzoate with at least one acidic highly alkalized substance in the presence of at least one alkaline earth metal sulfonate and a monohydric alcohol.

Cosmetic composition comprising (i) bemotrizinol (bis-ethylhexyloxyphenol methoxyphenyl triazine), (ii) a water-soluble organic UV filter or a salt thereof, (iii) at least one inorganic UV filter, wherein the cosmetic composition is free of the UV filters from the group consisting of hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl] benzoate (INCI diethylamino hydroxybenzoyl hexyl benzoate), 2,2' - M ethy I en bis [6- (2 H - benzotriazo I -2 -y I) -4- (1, 1,3,3 -tetra methyl butyl) phenol] (bisoctrizole), 3,3,5-Trimethy Icyclohexyl 2-hydroxybenzoate (I NCI Homosalate), polysilicone-15, and 2-hydroxy-4-methoxybenzophenone (I NCI benzophenone-3) and a method for increasing the water resistance of a cosmetic composition comprising bis-ethylhexyloxyphenol methoxyphenyl triazine (bemotrizinol), zinc oxide, and titanium dioxide comprising the step of adding a water-soluble organic UV filter or a salt thereof to the cosmetic composition.

A stabilized polymeric composition is disclosed comprising an organic polymeric material to be stabilized and a stabilizer composition comprising: at least one inorganic UV blocker, at least one hindered amine light stabilizer compound, at least one hindered phenol antioxidant compound, at least one phosphite or phosphonite compound, at least one thioester, and at least one flame retardant, wherein the stabilizer composition provides effective ultraviolet (UV) light stability, thermal stability, and gas fade resistance to the stabilized polymer even when hindered hydroxybenzoic acid esters, organic UV absorbers, acid scavengers, and / or dialkylhydroxylamines are not present.

The present disclosure is directed to a method of treating a disease or disorder selected from the group consisting of heart disease, neurodegenerative disease, migraine headache, neurodevelopmental disease, infertility, pulmonary disease, muscle disease, liver disease, pancreatic disease, oral disease, ophthalmic disease, hearing disease, diseases of pregnancy, diseases of prematurity, aging disorders, movement disorders, infectious disease, and any disease in which Coenzyme Q declines, in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of 4-hydroxymandelic acid (4-HMA), 4-hydroxybenzoate (4-HB), or a compound of Formula (I); where R1, R2, R3, and R4 are as described herein. The present disclosure is also directed to a method of improving wound healing in a subject and a method of treating a neurodevelopmental disorder with spastic paresis and brain white matter abnormalities.

The present invention provides a corrosion-inhibiting and viscosity-reducing composition, its preparation method, and application. The composition comprises an imidazoline compound, a parahydroxybenzoate compound, dimethyl carbonate, and polyacrylic acid, and maleic acid and a solvent. It is a corrosion inhibitor with both viscosity-reducing properties. The preparation method is simple, the raw materials are readily available, and the composition exhibits both viscosity-reducing and corrosion-inhibiting properties, making it suitable for application in oilfield corrosion protection.

The invention discloses an environment-friendly flame-retardant poly (aromatic ester-ether)-based biodegradable material polyester and a preparation method thereof. According to the method, 3-allyl-4-hydroxybenzoate, cyclohexyl-1, 4-dimethyl alcohol monovinyl ether and a specific halogen-free flame retardant allyl phosphate diester are taken as reaction monomers, and the environment-friendly flame-retardant poly (aromatic ester-ether) dihydric alcohol copolymer is synthesized through emulsion polymerization; and then, by taking the copolymer as a precursor, carrying out esterification and polycondensation on the copolymer, organic dibasic acid, a polyfunctional cross-linking agent and a stabilizer under the action of a catalyst to prepare the environment-friendly flame-retardant poly (aromatic ester-ether)-based biodegradable material polyester. According to the invention, the molecular design realizes the synergistic interaction of group enrichment effect and rigid structure effect for the first time, and breaks through the bottleneck of poor flame retardance of the traditional biodegradable material polyester; meanwhile, emission of corrosive gases such as dioxin and hydrogen halide during combustion is avoided, and the material is endowed with efficient biodegradability and green flame retardant property.