A novel compound isolated from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the composition comprising the same for preventing or treating allergy disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and the use thereof
A TECHNOLOGY FOR ALLERGIC DISEASES, CORONARY OBSTRUCTIVE APPLICATIONS TO NOVEL COMPOUNDS ISOLATED FROM PSEUDOLYSIMACHION ROTUNDUM VAR.SUBINTEGRUM CONTAINING LARGE ACTIVE INGREDIENTS FOR THE PREVENTION OR TREATMENT OF ALLERGIC DISEASES, INFLAMMARY DISEASES, ASTHMA OR CORONARY OBSTRUCTIVE Pulmonary disease compositions containing the compounds and their fields of use, capable of solving the problems of not exhibiting anti-inflammatory activity, anti-allergic activity, anti-asthma activity, and anti-COPD activity
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[0093] The following reference examples, examples and experimental examples are intended to further illustrate the present invention without limiting its scope.
reference example 1
[0094] Reference example 1. Analyzer
[0095]Melting point was measured by melting point measuring device (Koflermicrohostage) (without correction); optical rotation was measured by Jasco P-1020 polarimeter; UV data was measured by UV-VIS 2450 spectrometer; FT-IR spectrum was measured by Jasco FT / IR-4200 ; NMR spectra were determined by Varian UNITY 400MHz FT-NMR spectrometer using TMS as internal standard; HRESIMS was determined by Waters Q-TOF Premier spectrometer; and HPLC was performed by Gilson HPLC using UV / VIS-155 detector and pump 305 in the experiments analyze.
Embodiment 1
[0096] Example 1: Preparation of new compound (KS534) from Pseudolysinachion rotundum var. subintegrum
[0097] 1-1. Preparation of Crude Extract
[0098] 2.0 kg of dried Pseudolysimachion rotundum var.subintegrum (according to GAP, KRIBB0020697, KRIBB's plant extract bank, cultivated in Soi-myeon Eumseong-gun Chungcheongbuk-do, 244, Korea; Taejeon, Korea) was cut into small pieces, and mixed with 10 L 40% ethanol mix. The mixture was stirred at room temperature for 24 hours and reflux extracted at 78° C. for 12 hours three times to collect the filtrate. Filter the extract with filter paper to remove residue. The collected filtrate was concentrated under reduced pressure at 55°C-65°C by a rotary evaporator (EYELA, N-2100, Japan), and dried with a freeze dryer to obtain 198.7 g of dried crude extract.
[0099] 1-2. Preparation of purified extract
[0100] 20 g of the dried crude extract was dissolved in a mixed solvent (25% MeOH-water) and further purified by using preparat...
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