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A kind of probe and its preparation method and application

A technology of probes and reactants, applied in the field of probes and their preparation, can solve problems such as threats to health, difficulty in rapid decomposition, long-term residue, etc., and achieve direct analysis, simple operation, and visible test results

Active Publication Date: 2019-04-26
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Especially heavy metal ions are not easy to decompose quickly after entering the environment so that they can remain in the environment for a long time; and after entering the human body, they seriously threaten human health

Method used

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  • A kind of probe and its preparation method and application
  • A kind of probe and its preparation method and application
  • A kind of probe and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: a kind of probe, the molecular formula of described probe is: C 40 h 45 N 4 Br, the structural formula of the probe is attached figure 1 Shown; NMR spectrum as attached Image 6 shown.

Embodiment 2

[0040] Embodiment 2: a kind of preparation method of the probe described in embodiment 1, its steps are as follows:

[0041] (1) Using 4-bromobenzaldehyde, 2-acetylpyridine, 4-pyridineethylene and brominated alkanes, ammonia water, palladium acetate, triphenylphosphine, triethylamine and dimethylformamide (DMF) as raw materials, at 3°C Stir for 2 hours, reflux for 22 hours, and stir at room temperature for 45 minutes to obtain a precipitate, filter it, and recrystallize in acetic acid to obtain a reactant;

[0042] (2) The reactant in step (1) was taken out and cooled to room temperature to produce a precipitate, which was filtered to obtain a solid, and then the solid was dried to obtain a probe.

Embodiment 3

[0043] Embodiment 3: a kind of preparation method of the probe described in embodiment 1, its steps are as follows:

[0044] (1) With 4-bromobenzaldehyde, 2-acetylpyridine, 4-pyridineethylene and brominated alkanes, ammonia water, palladium acetate, triphenylphosphine, triethylamine and dimethylformamide (DMF) at 0°C Stir for 3 hours, reflux for 18 hours, and stir at room temperature for 30 minutes to obtain a precipitate, filter it, and recrystallize in acetic acid to obtain a reactant;

[0045] (2) The reactant in step (1) was taken out and cooled to room temperature to produce a precipitate, which was filtered to obtain a solid, and then the solid was dried to obtain a probe.

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Abstract

The invention discloses a probe and a preparation method and application thereof. The preparation method includes mixing and stirring 4-bromobenzaldehyde, 2-acetylpyridine, 4-vinyl pyridine, brominated alkanes, ammonium hydroxide, palladium acetate, triphenyl phasphine, triethylamine and DMF (dimethylformamide) prior to reflux, stirring for 1 hour at a room temperature to obtain a precipitate, filtering and recrystallizing in acetic acid so as to obtain a reactant; taking the reactant out, cooling the reactant to the room temperature to generate a precipitate, filtering to obtain a solid and drying the solid so as to obtain the probe. The probe is capable of quantitatively analyzing Zn<2+> concentration in a solution and has the advantages of low quantitative analysis concentration, high anti-interference capability, simplicity in operation, visual results and simplicity and convenience in analysis.

Description

technical field [0001] The invention relates to a probe and its preparation method and application, in particular to a fluorescent probe and its preparation method and application. Background technique [0002] The pollution problem caused by metals and their related ions is a serious environmental and social problem. Especially heavy metal ions are not easy to decompose quickly after entering the environment so that they can remain in the environment for a long time; and after entering the human body, they seriously threaten human health. For example, zinc ion, which is the second most abundant transition metal ion, plays an important role in many physiological processes, such as structural and catalytic factors, signal transmission and regulation, gene expression regulation and cell apoptosis. Studies have shown that the imbalance of zinc ion metabolism is closely related to many serious neurological diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis, Pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D213/22C07D213/127C09K11/06G01N21/64
CPCC07D213/127C07D213/22C09K11/06C09K2211/1007C09K2211/1029G01N21/643
Inventor 倪新龙白青鸿夏宇龚雪张少威
Owner GUIZHOU UNIV
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