Application of ART (artesunate) as anti-leukemia-tumor drug

A technology of artesunate and leukemia, applied in the field of medical and health care, can solve the problems of poor radiotherapy/chemotherapy and short survival time of leukemia tumors

Inactive Publication Date: 2017-08-18
AFFILIATED HOSPITAL OF ZUNYI MEDICAL COLLEGE
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0010] In order to solve the technical problems of leukemic tumors treated by Western medicine in the prior art, such as damage to the human body, poor radiotherapy/chemotherapy effects, and short survival time after treatment, the present invention provides the application of ar

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  • Application of ART (artesunate) as anti-leukemia-tumor drug
  • Application of ART (artesunate) as anti-leukemia-tumor drug
  • Application of ART (artesunate) as anti-leukemia-tumor drug

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Embodiment Construction

[0019] Below in conjunction with accompanying drawing, the present invention will be further described:

[0020] The application of artesunate as an anti-leukemia tumor drug is characterized in that: the artesunate is used as a chemotherapy drug for leukemia tumor targeting inhibition of STAT3.

[0021] Further, when the artesunate is used as a chemotherapeutic drug targeting leukemia tumors to inhibit STAT3, the combination of artesunate and artesunate also includes chemotherapeutic drugs such as cytarabine, daunorubicin, nordauroxin Amycin, doxorubicin, homocentiline, asparaginase, pegasparaginase, all-trans retinoic acid, arsenic trioxide, dexamethasone, choose one or more of the above-mentioned ones to form with artesunate Combination drugs.

[0022] Further, the application of artesunate as an anti-leukemia tumor drug is characterized in that: the anti-leukemia tumor drug is a group of traditional Chinese medicine extracts, which also includes ursolic acid.

[0023] Urs...

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Abstract

The invention provides an application of ART (artesunate) as an anti-leukemia-tumor drug and relates to the field of medical health. ART is taken as a chemotherapeutic drug with targeted inhibition of STAT3 for leukemia tumor. Expression level of STAT3 can be inhibited rapidly and effectively, so that leukemia treatment is realized, ART has a strong inhibition effect on THP-1 cell proliferation and can induce THP-1 apoptosis, and the fact that ART can remarkably reduce protein level of STAT3 and activate Caspase8 and Caspase3 protein simultaneously to induce apoptosis is further proved. Intraperitoneal injection of ART into a THP-1 cell transplantation tumor mouse model discovers that ART can obviously inhibit tumor growth and down-regulate the expression level of STAT3 in tumor tissue. Experiments prove that ART plays an anti-tumor effect on THP-1 by down-regulating expression of STAT3 and activating apoptotic proteins Caspase8 and Caspase3 simultaneously.

Description

technical field [0001] The invention relates to the field of medical and health care, in particular to a drug that has basically no toxic and side effects on the human body and has an excellent effect. The drug refers to a chemotherapy drug that uses artesunate as a targeted inhibitor of STAT3 for leukemia tumors. Background technique [0002] In recent years, with various internal and external factors such as high work pressure, environment, food, and radioactive substances, the number of cancer patients has been showing a rapid growth trend. Leukemia is a malignant disease of hematopoietic stem / progenitor cells. The main feature is the abnormal proliferation of primitive and immature cells in bone marrow and peripheral blood. The clinical manifestations are anemia, hemorrhage, infection and fever, visceral infiltration, abnormal metabolism, etc. Most cases are acute and severe, and the prognosis is dire. life threatening. There are chemotherapy, induced differentiation (...

Claims

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Application Information

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IPC IPC(8): A61K31/357A61K31/56A61K31/122A61P35/00A61P35/02
CPCA61K31/122A61K31/357A61K31/56A61K2300/00
Inventor 陈艳谭梅
Owner AFFILIATED HOSPITAL OF ZUNYI MEDICAL COLLEGE
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