Application of ART (artesunate) as anti-leukemia-tumor drug

Abstract

The invention provides an application of ART (artesunate) as an anti-leukemia-tumor drug and relates to the field of medical health. ART is taken as a chemotherapeutic drug with targeted inhibition of STAT3 for leukemia tumor. Expression level of STAT3 can be inhibited rapidly and effectively, so that leukemia treatment is realized, ART has a strong inhibition effect on THP-1 cell proliferation and can induce THP-1 apoptosis, and the fact that ART can remarkably reduce protein level of STAT3 and activate Caspase8 and Caspase3 protein simultaneously to induce apoptosis is further proved. Intraperitoneal injection of ART into a THP-1 cell transplantation tumor mouse model discovers that ART can obviously inhibit tumor growth and down-regulate the expression level of STAT3 in tumor tissue. Experiments prove that ART plays an anti-tumor effect on THP-1 by down-regulating expression of STAT3 and activating apoptotic proteins Caspase8 and Caspase3 simultaneously.

Description

technical field [0001] The invention relates to the field of medical and health care, in particular to a drug that has basically no toxic and side effects on the human body and has an excellent effect. The drug refers to a chemotherapy drug that uses artesunate as a targeted inhibitor of STAT3 for leukemia tumors. Background technique [0002] In recent years, with various internal and external factors such as high work pressure, environment, food, and radioactive substances, the number of cancer patients has been showing a rapid growth trend. Leukemia is a malignant disease of hematopoietic stem / progenitor cells. The main feature is the abnormal proliferation of primitive and immature cells in bone marrow and peripheral blood. The clinical manifestations are anemia, hemorrhage, infection and fever, visceral infiltration, abnormal metabolism, etc. Most cases are acute and severe, and the prognosis is dire. life threatening. There are chemotherapy, induced differentiation (...

AI Technical Summary

Problems solved by technology

[0010] In order to solve the technical problems of leukemic tumors treated by Western medicine in the prior art, such as damage to the human body, poor radiotherapy / chemotherapy effects, and short survival time after treatment, the present invention provides the application of artesunate as an anti-leukemic tumor drug, which can be greatly improved. Improve the inhibition of leukemia tumors during treatment, improve the effective rate of treatment and cure rate of patients, prolong the survival time of patients, and reduce the recurrence rate after cure

Images