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Apparatus and methods for analyzing the output of microfluidic devices

A technology of microfluidic devices and microfluidic channels, applied in the field of microfluidics, can solve problems such as not easy to modify for monitoring, complex optical devices, etc.

Active Publication Date: 2017-08-29
THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these techniques require complex optics and are not easily modified to monitor more than one channel

Method used

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  • Apparatus and methods for analyzing the output of microfluidic devices
  • Apparatus and methods for analyzing the output of microfluidic devices
  • Apparatus and methods for analyzing the output of microfluidic devices

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Embodiment Construction

[0041] Aspects of the invention relate to apparatus and methods for analyzing the output of a microfluidic device.

[0042] The inventors have realized that it would be useful to provide a full analysis of the output of a microfluidic device. The present inventors have also realized that using a different micropatterned mask for each channel of the microfluidic device to encode the signal from the output, such as a droplet, enables the recovery of weak signals without the need for expensive and bulky photodetectors . The present inventors have also realized that the use of masks allows multiple channels to be monitored simultaneously, allowing increasingly complex experiments without the need for additional and expensive detection hardware such as lenses, lasers and complex fluid control hardware. In particular, the microfluidic devices of the present invention can use a single detector to measure droplets in multiple channels, even simultaneously, and do not require lenses o...

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Abstract

Microfluidic devices for analyzing droplets are disclosed. A described microfluidic device includes a substrate and a microfluidic channel formed on the substrate. The microfluidic channel includes passages where each passage has a mask pattern configured to modulate a signal of a droplet passing through that passage, such that droplets passing through the passages produce signals. The microfluidic device also includes a detector configured to detect the signals. Methods of analyzing droplets with a microfluidic device having a microfluidic channel formed on a substrate are disclosed. A described method includes passing droplets through the passages, modulating signals form the droplets using mask patterns formed on the passages; and detecting the signals.

Description

[0001] Cross References to Related Applications [0002] This PCT application claims priority to US Provisional Patent Application No. 62 / 037,273, filed August 14, 2014, the disclosure of which is hereby incorporated by reference in its entirety for all purposes. technical field [0003] The present invention relates to the field of microfluidics, and more particularly to devices and processes for analyzing the output of microfluidic devices, such as droplets. Background technique [0004] Droplet-based assays using microscale emulsions as isolated compartments to run multiple independent chemical reactions have gained popularity in recent years as platforms for a wide range of biomedical applications. Micron-sized droplets contain only (10-12L) picoliters of fluid, providing 10 6 doubled down. Further, microfluidics allows processing at up to 10 6 The rate to create droplets, thereby providing the number of compartments greater than 10 of the conventional technology 4 t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/63
CPCB01L3/502715G01N21/6428B01L3/502784B01L2300/0627B01L2300/0861B01L2300/0654G01N2015/1481G01N21/6486G01N2201/063G01N27/221G01N27/74G01N29/022
Inventor 大卫·伊萨多尔梅拉库·穆伦内·沃尔德马里亚姆
Owner THE TRUSTEES OF THE UNIV OF PENNSYLVANIA