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Anti-tumor application of sophora subprostrate polysaccharide effective parts

An effective part, anti-tumor technology, applied in the field of medicine, can solve the problems of no acute toxicity and hepatotoxicity medicinal value, etc., achieve obvious application prospects and clinical application value, and significant anti-tumor effect

Active Publication Date: 2017-09-05
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there are no research reports on the acute toxicity and liver toxicity of the active part of bean root polysaccharide and the research report on the medicinal value of the part after the toxicity is reduced.

Method used

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  • Anti-tumor application of sophora subprostrate polysaccharide effective parts
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  • Anti-tumor application of sophora subprostrate polysaccharide effective parts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0024] Example: Preparation of effective fractions of polysaccharides from bean root

[0025] a) Take 8 kg of mountain bean root decoction pieces, soak in 48 kg of water for 60 minutes, then heat and reflux for 1 hour, filter the decoction at 200 mesh, add 48 kg of water to heat and reflux and decoct for 1 hour, filter the decoction with 200 mesh, combine the two second filtrate to obtain the decoction of the root of the mountain bean;

[0026] b) At 75-80°C, decompress and concentrate the decoction of the root of the mountain bean root to a concentration of 1.5kg / L, then heat it under normal pressure at 98°C for 1.5 hours, and then cool it to room temperature to obtain the root of the mountain root water extract;

[0027] c) adding ethanol with a volume fraction of 95% to the aqueous extract of the bean root obtained in step b), stirring while adding, until the final volume fraction of ethanol is 80%, standing still, and collecting the precipitate;

[0028] d) Carry out gra...

Embodiment 1

[0033] Weigh 8 kg of shredded mountain bean root, soak it overnight with 12 times the dosage of water, heat and extract for 2 hours, pour out the water, centrifuge while it is hot (3000r / min, 10min), continue to add 10 times and 8 times the dosage of water to heat the dregs respectively Extract for 1.5h and 1h, respectively pour out the water and centrifuge while it is hot, concentrate the water in reverse gradient to 1:1 (1g of crude drug is equivalent to 1mL), add ethanol with a volume fraction of 95% to make the alcohol content reach 80%. Centrifuge after overnight, add 1:50 hot water to dissolve the precipitate and then centrifuge, add 95% ethanol to the water solution to make the alcohol content reach 80%, let stand at low temperature overnight, centrifuge, add 95% ethanol to the precipitate, stir and then centrifuge, The precipitate was vacuum-dried (40° C.), and 257.6 g of the water-extracted and alcohol-precipitated part of the root of the mountain bean root was obtaine...

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Abstract

The invention discloses an anti-tumor application of sophora subprostrate polysaccharide effective parts. Alcohol precipitation of water extracts of sophora subprostrate is performed, the water extracts after alcohol precipitation are dried in a classified manner to obtain the sophora subprostrate polysaccharide effective parts. The mass percent of polysaccharide is larger than or equal to 65%, the mass percent of matrine is smaller than 0.5%, and the application is that the sophora subprostrate polysaccharide effective parts serve as active components to prepare anti-tumor medicines. Experiments show that the sophora subprostrate polysaccharide effective parts have remarkable anti-tumor activity, immunological enhancement effect, obvious application prospect and clinical application values and are safe and low in toxicity, so that the effective parts can be hopefully used for preparing anti-tumor medicines, and particularly, can be hopefully used for preparing anti-breast-cancer medicines and anti-lung cancer medicines.

Description

technical field [0001] The invention relates to the anti-tumor application of the effective part of the polysaccharide of bean root, which belongs to the technical field of medicine. Background technique [0002] Tumor is a global disease that seriously endangers human health. According to the "2012 Global Cancer Statistics" report released in 2015: In 2012, there were about 14.1 million new cancer cases worldwide, of which 8.2 million patients died of cancer, of which 57 65% of cancer patients and 65% of cancer deaths are from developing countries. In 2012, the number of cancer cases in China was 3.065 million, accounting for one-fifth of the global incidence; the number of cancer deaths was 2.205 million, accounting for one-quarter of the global cancer deaths. Therefore, it is imminent to find new anticancer drugs. [0003] Shandougen is the dry root and rhizome of Sophora tonkinensis Gagnep, a leguminous plant, mainly produced in Guangxi, Guangdong, Guizhou and other pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K31/715A61P35/00
CPCA61K31/715A61K36/489A61K2236/331A61K2236/51A61K2236/53
Inventor 邓中平金冰亮杨以阜陈春麟李春启
Owner SHANGHAI UNIV OF T C M
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