Traditional Chinese medicine compound composition with anti-tumor activity and preparation method and application thereof

A technology of anti-tumor activity and composition, which is applied in the direction of anti-tumor drugs, drug combinations, and medical preparations containing active ingredients, etc., which can solve the problems of large adverse reactions, high toxicity of chemotherapy drugs, and low survival rate of patients, and achieve The effects of strengthening the body's immune function, inhibiting the growth of tumor cells, and improving the quality of life

Inactive Publication Date: 2017-09-12
江苏亚邦中药饮片有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, the current drugs for treating tumors mainly include chemical drugs. However, due to the high toxicity of chemotherapy drugs, they can not selectively kill white blood cells, lymphocytes and other

Method used

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  • Traditional Chinese medicine compound composition with anti-tumor activity and preparation method and application thereof
  • Traditional Chinese medicine compound composition with anti-tumor activity and preparation method and application thereof
  • Traditional Chinese medicine compound composition with anti-tumor activity and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0033] 2. the preparation method of the Chinese medicine compound composition with antitumor activity of the present invention, comprises the following steps:

[0034] (1) Get 150 parts of Radix Astragali by weight, 20 parts of Dendrobium officinale, 45 parts of Malancao, 60 parts of Saponaria thorn, 40 parts of Passepartout, 20 parts of Ornithus fragrans, 30 parts of Catgrass, 20 parts of Tiankuizi , 30 parts of schisandra, 30 parts of burnet, 30 parts of madder, 30 parts of chrysanthemum, 20 parts of mallow seed, 20 parts of shijianchuan, 20 parts of leaking reed, 40 parts of licorice, add 8 times the amount of total medicinal materials to ethanol reflux extraction 3 times, the combined extracts were concentrated under reduced pressure to obtain a concentrate;

[0035] (2) Take 20 parts of hives, 8 parts of leeches and 40 parts of Gorgon fruit in parts by weight, add 8 times the amount of water of the total medicinal materials to extract twice, combine the extracts, and conc...

Embodiment 5

[0069] Example 5 In Vitro Anticancer Experiment

[0070] Cell lines: Human breast cancer, brain cancer and prostate cancer were provided by Pharmacology Laboratory of Nanjing University of Traditional Chinese Medicine; 96-well plate was purchased from Costar Company; RMPI1640 medium was purchased from Gibco Company; DMEM medium was purchased from Gibco Company; newborn bovine serum was purchased from From Hangzhou Sijiqing Company; Thiazole Blue (MTT) and DMSO were purchased from Amresco;

[0071] The experimental equipment used in the following examples is as follows:

[0072] Experimental equipment: ultra-clean bench (Suzhou purification model SW-CJ-IFD), CO 2 Incubator (SANYO model: XD-101), microplate reader BIO-RAD (Model NO.550Serial NO.16971).

[0073] The experimental method used in the following examples is as follows:

[0074] Experimental method: use the improved MTT method to conduct an in vitro anti-tumor cell experiment on the traditional Chinese medicine comp...

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Abstract

The invention discloses a traditional Chinese medicine compound composition with anti-tumor activity and a preparation method and application thereof. The traditional Chinese medicine compound composition is prepared from the following components in parts: 50 to 150 parts of radix astragali seu hedysari, 5 to 25 parts of herba dendrodii officinalis, 20 to 65 parts of herba kalimeridis, 30 to 90 parts of spina gleditsiae, 20 to 60 parts of fructus liquidambaris, 10 to 40 parts of honeycomb, 15 to 45 parts of herba rabdosiae, 15 to 45 parts of radix ranunculi ternati, 10 to 40 parts of radix semiaquilegiae, 10 to 30 parts of fructus schisandrae chinensis, 10 to 30 parts of radix sanguisorbae, 3 to 12 parts of hirudo, 10 to 40 parts of radix rubiae, 15 to 45 parts of rhizoma paridis, 10 to 30 parts of chingma abutilon seed, 10 to 20 parts of herba salviae Chinensis, 10 to 20 parts of uniflower swisscentaury root, 20 to 60 parts of liquorice root and 30 to 60 parts of semen euryales. Proofed by anti-tumor experiment, the traditional Chinese medicine compound composition has the advantages that the proportional ratio is scientific and reasonable, the strong killing function on multiple malicious tumor cells is realized, the poor reaction is low, the safety is good, and the application range is wide.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a compound traditional Chinese medicine composition with anti-tumor activity and its preparation method and application. Background technique [0002] Tumor has become the number one killer threatening human existence in the 21st century. China is one of the countries with high incidence of cancer in the world, and it shows a rapid growth trend every year. Clinically, the current drugs for treating tumors mainly include chemical drugs. However, due to the high toxicity of chemotherapy drugs, they can not selectively kill white blood cells, lymphocytes and other human immune cells while killing tumor cells. As a result, patients often suffer from autoimmune diseases. Complicated infection due to low ability, severe adverse reaction, low survival rate and high cost. [0003] Traditional Chinese medicine has unique advantages in the treatment of tumors. Natural drugs represented by...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P35/00A61K35/64A61K35/62
CPCA61K35/62A61K35/63A61K36/185A61K36/28A61K36/481A61K36/483A61K36/484A61K36/53A61K36/57A61K36/62A61K36/71A61K36/739A61K36/74A61K36/79A61K36/896A61K36/8984A61K2236/33A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 李志成程海波孙东东沈卫星李柳曹岗谭佳妮徐长亮苗筠杰范汇森
Owner 江苏亚邦中药饮片有限公司
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