A staggered release double sustained-release coating multifunctional small-caliber artificial blood vessel and preparation method thereof

Abstract

The invention is a multi-functional small-caliber artificial blood vessel with staggered release double sustained-release coatings, including artificial blood vessels. The inner and outer surfaces of the artificial blood vessels are sprayed with double-layer coatings, and the inner coating of the double-layered coatings is PTX sustained-release PDMS. Coating PTX-PDMS, the outer coating of the double-layer coating is a biodegradable polylactic-glycolic acid copolymer nanoparticle slow-release coating PLGA-NPs that encapsulates the VEGF gene. Small-diameter PET blood vessels consisting of an inner layer of PTX-PDMS coating and an outer layer of PLGA-NPs slow-release coating that encapsulates VEGF gene, so as to achieve early implantation of VEGF gene transfection and expression to promote rapid endothelialization of the inner wall of the blood vessel, and PTX to continue in the later period. The purpose of sustained release to inhibit subsequent intimal hyperplasia ensures that the multifunctional artificial blood vessel produces a synergistic effect between promoting endothelial cell migration, proliferation and maturation and inhibiting medial vascular smooth muscle cell proliferation, thereby ensuring good vascular endothelialization after implantation And long-term patency, can promote the significant improvement of long-term patency of small-diameter artificial blood vessels.

Description

technical field [0001] The invention relates to a medical artificial blood vessel and a preparation method thereof, in particular to a multifunctional small-caliber artificial blood vessel with a double slow-release coating at staggered time and a preparation method thereof. Background technique [0002] According to statistics, there are more than 30 million patients with peripheral vascular occlusive disease (PAD) and more than 1 million patients with end-stage renal disease in China, of which the number of patients with end-stage renal disease is increasing by 120,000 every year. In order to save the limbs of PAD patients and maintain the "life access" of patients with end-stage renal disease, vascular reconstruction or the establishment of arteriovenous access is the most important treatment method, and a large number of patients need to use small-caliber artificial blood vessels due to the limitation of autologous blood vessels. Blood vessels (SDVPs, diameter ≤6cm). Ho...

AI Technical Summary

Problems solved by technology

These studies have solved the problem of endothelialization of the inner wall of artificial blood vessels to varying degrees. CD34 antibody and VEGF curing are facing problems such as difficult control of endothelial cell proliferation, imperfect slow-release technology, and late anastomotic intimal hyperplasia, especially the latter has yet to be resolved

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