Self-anticoagulation developable small-caliber artificial intravascular stent and preparation method thereof

Abstract

The invention relates to a self-anticoagulation developable small-caliber artificial intravascular stent and a preparation method thereof. A provided artificial intravascular stent material is prepared from a nanofiber with a core-shell structure, and the nanofiber is prepared by taking a contrast agent and polycaprolactone as core-layer raw materials and taking an anticoagulant and polycaprolactone as shell-layer raw materials. The aperture of the small-aperture artificial intravascular stent prepared from the artificial intravascular stent material is smaller than 6 mm, the self-anticoagulation performance is remarkably improved, the long-term blood vessel patency rate is remarkably increased, and thrombus formation by vascular anastomotic stoma can be effectively inhibited. Meanwhile, the small-caliber artificial intravascular stent further has excellent developing capacity, the degradation condition of the intravascular stent can be conveniently monitored after an operation, bloodvessel positioning is carried out on postoperative reexamination of a patient, and discomfort brought to a human body due to injection of a contrast agent in a reexamination process is avoided. The small-caliber artificial intravascular stent provided by the invention has a good application prospect in a vascular transplantation operation.

Description

technical field [0001] The invention belongs to the field of vascular stents, and in particular relates to a self-anticoagulant and developable small-diameter artificial vascular stent and a preparation method thereof. Background technique [0002] Cardiovascular disease is one of the common diseases that endanger human health. Patients suffer from vascular injury caused by trauma, arteriosclerosis and vascular embolism. Among them, coronary heart disease is one of the main cardiovascular diseases that endanger human life and health at present, and its incidence rate is getting higher and higher, and the patients are getting younger. Coronary heart disease, also known as coronary atherosclerotic heart disease, is caused by atherosclerotic lesions in the coronary arteries of the human body, resulting in narrowing of the inside of the blood vessels. In severe cases, they are all blocked, resulting in myocardial ischemia, hypoxia or necrosis. At present, the treatment methods ...

AI Technical Summary

Problems solved by technology

Most of the artificial vascular stents synthesized by these materials are large-caliber (aperture greater than 6mm) artificial vascular stents, which have achieved remarkable results in surgical treatment and interventional treatment of large-caliber vessels. However, for small-caliber vessels (aperture less than 6mm, Such as extremity arteries, coronary arteries, etc.), there are still many serious problems, and satisfactory clinical results have not been obtained.

[0005] In clinical application, the main problem of small-caliber artificial vascular stents is that platelet aggregation is easily caused when blood contacts the lumen, and thrombosis is easy to form at the vascular anastomosis, which endangers the safety of the operation and the life of the patient, and reduces the long-term patency of the blood vessels.

In addition, postoperative reexamination is usually required after the operation to monitor the condition of the artificial blood vessel in the body, and the blood vessel is soft tissue, which is generally located in a deeper position in the human body. Ordinary CT imaging or MRI imaging of small-diameter artificial blood vessel stents Poor ability

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