Anticancer preparation containing Apatuoxin F and/or G, and preparation method and application thereof

A technology of apatoxine and preparations, applied in the field of anticancer preparations containing apatoxine F and/or G and preparation thereof, can solve the problems of pancreatic damage, side effects of apatoxine A and the like, and achieve strong killing effect of action

Inactive Publication Date: 2017-10-20
约瑟夫伯恩(北京)医院管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the Apatoxine family, it was found that Apatoxine A, F and G have a strong effect of killing cancer cells, but Apatoxine A has obvious side effects, such as pancreatic damage, etc.

Method used

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  • Anticancer preparation containing Apatuoxin F and/or G, and preparation method and application thereof
  • Anticancer preparation containing Apatuoxin F and/or G, and preparation method and application thereof
  • Anticancer preparation containing Apatuoxin F and/or G, and preparation method and application thereof

Examples

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preparation example Construction

[0051] The present invention provides a kind of preparation method that comprises the anticancer preparation of Apatuxin F and / or G, comprises the following steps:

[0052] Step 1: Use one or both of Apatosine F and G (i.e. Apatosine F, Apatosine G, or Apatosine F and G) with dimethyl sulfoxide (analytical pure or Pharmaceutical grade, the mass fraction is above 99%) dissolved, and the concentration of apatuxine F and / or G after dissolution meets 2-100mg / ml, (preferably 10-30mg / ml, more preferably 10mg / ml);

[0053] Step 2: Prepare the dimethyl sulfoxide dissolved with Apatuxine F and / or G into a powder injection, the particle size of the powder injection is 40-120 microns, preferably (60-80 microns);

[0054] Step 3: Add polyoxyethylene castor oil propylene glycol mixed solution equal to the volume of dimethyl sulfoxide used for dissolving to the powder injection, the mixed solution is polyoxyethylene castor oil (analytical pure or pharmaceutical grade) and analytical Pure o...

Embodiment 1

[0070] The present embodiment provides an anticancer preparation comprising apatuxin F, and the preparation process of the formula of the anticancer preparation is as follows:

[0071] Step 1: Dissolve Apatuxine F in dimethyl sulfoxide, and the concentration of Apatuxine F after dissolution should meet 2mg / ml;

[0072] Step 2: Prepare the dimethyl sulfoxide dissolved with Apatoxine F into a powder injection, the particle size of the powder injection is 40 microns;

[0073] Step 3: Add polyoxyethylene castor oil propylene glycol mixed liquid of polyoxyethylene castor oil propylene glycol mixture with the volume of dimethyl sulfoxide equal to the volume of dimethyl sulfoxide used in the previous dissolution to the powder injection, and mix well to obtain the product containing apatoxine F Anticancer agents. The oxyethylene castor oil-propylene glycol mixture is a mixture of polyoxyethylene castor oil (analytical pure or pharmaceutical grade) and propylene glycol (analytical pur...

Embodiment 2

[0076] The present embodiment provides an anticancer preparation comprising apatuxin F, and the preparation process of the formula of the anticancer preparation is as follows:

[0077] Step 1: Dissolve Apatuxine F in dimethyl sulfoxide, and the concentration of Apatuxine F after dissolution should meet 10 mg / ml;

[0078] Step 2: Prepare the dimethyl sulfoxide dissolved with Apatoxin F into a powder injection, the particle size of which is 60 microns;

[0079] Step 3: Add polyoxyethylene castor oil propylene glycol mixed liquid of polyoxyethylene castor oil propylene glycol mixture with the volume of dimethyl sulfoxide equal to the volume of dimethyl sulfoxide used in the previous dissolution to the powder injection, and mix well to obtain the product containing apatoxine F Anticancer agents. The oxyethylene castor oil-propylene glycol mixture is a mixture of polyoxyethylene castor oil (analytical pure or pharmaceutical grade) and propylene glycol (analytical pure or pharmaceu...

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Abstract

The invention relates to an anticancer preparation containing Apatuoxin F and / or G, and a preparation method and application thereof. The anticancer preparation comprises Apatuoxin F and / or G, dimethyl sulfoxide, polyoxyethylated castor oil and propylene glycol, wherein a volume ratio of polyoxyethylated castor oil to propylene glycol is (20-80): (80-20), the mass concentration of Apatuoxin F and / or G is 2 to 100 mg / ml, and the mass concentration of dimethyl sulfoxide is 1.1 g / ml. The anticancer preparation containing Apatuoxin F and / or G is dissolved in normal saline, a glucose-normal saline solution or a glucose solution ccording to a volume ratio of 1: (9-125) so as to form an anticancer intravenous injection. The anticancer preparation containing Apatuoxin F and / or G provided by the invention has treatment effect on colorectal carcinoma and pancreatic carcinoma and low side reaction.

Description

technical field [0001] The invention relates to an anticancer drug, in particular to an anticancer preparation containing apatuxin F and / or G, a preparation method and application thereof. Background technique [0002] The recently released large-scale global cancer survey shows that in 2015, there were 17.5 million cancer patients and 8.7 million deaths worldwide. Compared with 2005, the incidence of cancer increased by 33% in 2015. [0003] In 2015, the top 10 cancers with the highest incidence worldwide were: lung cancer, liver cancer, gastric cancer, colorectal cancer, breast cancer, leukemia, esophageal cancer, pancreatic cancer, brain tumor and cervical cancer. [0004] In 2015, the top 10 cancers in my country were lung cancer, gastric cancer, liver cancer, breast cancer, colorectal cancer, esophageal cancer, leukemia, lymphoma, bladder cancer, and uterine cancer. [0005] In 2015, the top 10 cancer mortality rates in my country were: lung cancer, liver cancer, gast...

Claims

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Application Information

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IPC IPC(8): A61K31/429A61K45/06A61P35/00
CPCA61K31/429A61K45/06A61K2300/00
Inventor 邵家驹廖文强
Owner 约瑟夫伯恩(北京)医院管理有限公司
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