Anticancer preparation containing Apatuoxin F and/or G, and preparation method and application thereof
A technology of apatoxine and preparations, applied in the field of anticancer preparations containing apatoxine F and/or G and preparation thereof, can solve the problems of pancreatic damage, side effects of apatoxine A and the like, and achieve strong killing effect of action
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[0051] The present invention provides a kind of preparation method that comprises the anticancer preparation of Apatuxin F and / or G, comprises the following steps:
[0052] Step 1: Use one or both of Apatosine F and G (i.e. Apatosine F, Apatosine G, or Apatosine F and G) with dimethyl sulfoxide (analytical pure or Pharmaceutical grade, the mass fraction is above 99%) dissolved, and the concentration of apatuxine F and / or G after dissolution meets 2-100mg / ml, (preferably 10-30mg / ml, more preferably 10mg / ml);
[0053] Step 2: Prepare the dimethyl sulfoxide dissolved with Apatuxine F and / or G into a powder injection, the particle size of the powder injection is 40-120 microns, preferably (60-80 microns);
[0054] Step 3: Add polyoxyethylene castor oil propylene glycol mixed solution equal to the volume of dimethyl sulfoxide used for dissolving to the powder injection, the mixed solution is polyoxyethylene castor oil (analytical pure or pharmaceutical grade) and analytical Pure o...
Embodiment 1
[0070] The present embodiment provides an anticancer preparation comprising apatuxin F, and the preparation process of the formula of the anticancer preparation is as follows:
[0071] Step 1: Dissolve Apatuxine F in dimethyl sulfoxide, and the concentration of Apatuxine F after dissolution should meet 2mg / ml;
[0072] Step 2: Prepare the dimethyl sulfoxide dissolved with Apatoxine F into a powder injection, the particle size of the powder injection is 40 microns;
[0073] Step 3: Add polyoxyethylene castor oil propylene glycol mixed liquid of polyoxyethylene castor oil propylene glycol mixture with the volume of dimethyl sulfoxide equal to the volume of dimethyl sulfoxide used in the previous dissolution to the powder injection, and mix well to obtain the product containing apatoxine F Anticancer agents. The oxyethylene castor oil-propylene glycol mixture is a mixture of polyoxyethylene castor oil (analytical pure or pharmaceutical grade) and propylene glycol (analytical pur...
Embodiment 2
[0076] The present embodiment provides an anticancer preparation comprising apatuxin F, and the preparation process of the formula of the anticancer preparation is as follows:
[0077] Step 1: Dissolve Apatuxine F in dimethyl sulfoxide, and the concentration of Apatuxine F after dissolution should meet 10 mg / ml;
[0078] Step 2: Prepare the dimethyl sulfoxide dissolved with Apatoxin F into a powder injection, the particle size of which is 60 microns;
[0079] Step 3: Add polyoxyethylene castor oil propylene glycol mixed liquid of polyoxyethylene castor oil propylene glycol mixture with the volume of dimethyl sulfoxide equal to the volume of dimethyl sulfoxide used in the previous dissolution to the powder injection, and mix well to obtain the product containing apatoxine F Anticancer agents. The oxyethylene castor oil-propylene glycol mixture is a mixture of polyoxyethylene castor oil (analytical pure or pharmaceutical grade) and propylene glycol (analytical pure or pharmaceu...
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