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Adsorbing agent used for adsorbing toxins in renal failure patients and preparation method of adsorbing agent

A technology of adsorbent and endotoxin, which is applied in the field of medicine, can solve the problems of high frequency of dialysis, achieve the effect of increasing blood circulation, improving the quality of life, and having no toxic and side effects

Inactive Publication Date: 2017-10-20
吴越
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As the number of patients with chronic renal failure increases, the complications caused by it also increase, such as hypertension, anemia, heart failure, pericarditis, cardiomyopathy, hydroelectric disturbance, etc.; the main treatment method is dialysis , kidney transplantation and drug therapy, etc. Among them, dialysis is still the main clinical method for the treatment of chronic renal failure, but dialysis requires long-term maintenance treatment and the frequency of dialysis is high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] The present invention provides a preparation method for absorbing toxin adsorbent in patients with renal failure, comprising the following steps:

[0027] S101: Select an adsorbent with a particle size of 1 mm to 1.5 mm, and then perform low-temperature skeleton carbonization treatment. Wherein, the conditions of low-temperature skeleton carbonization are: temperature is 350°C-500°C, time is 2h-3h; the raw material components of the adsorbent include: 10-15 parts by weight of activated carbon and 5-8 parts by weight of cationic resin.

[0028] S102: The adsorbent after the low-temperature skeleton carbonization treatment is subjected to a medium-temperature impurity removal treatment in an inert gas atmosphere. Wherein, the medium-temperature impurity removal treatment specifically includes: the temperature is 500°C-600°C, and the time is 2h-3h.

[0029] S103: Perform pore-forming treatment on the adsorbent after the medium-temperature impurity removal treatment under ...

Embodiment 1

[0035] The present invention provides a preparation method for absorbing toxin adsorbent in patients with renal failure, comprising the following steps:

[0036] S101: Select an adsorbent with a particle size of 1 mm to 1.5 mm, and then conduct a low-temperature skeleton carbonization treatment at 500° C. for 2 hours. Wherein, the raw material components of the adsorbent include, by weight, 15 parts by weight of activated carbon and 5 parts by weight of cationic resin.

[0037] S102: The adsorbent after the low-temperature skeleton carbonization treatment is subjected to a medium-temperature impurity removal treatment at 500° C. for 3 hours in an inert gas atmosphere.

[0038] S103: Perform pore-forming treatment at 650° C. on the adsorbent after the treatment of removing impurities at a medium temperature under the action of a mixed gas. Among them, the mixed gas includes carbon dioxide and water vapor with a volume ratio of 1:10.

[0039] S104: Perform pore activation trea...

Embodiment 2

[0041] The present invention provides a preparation method for absorbing toxin adsorbent in patients with renal failure, comprising the following steps:

[0042] S101: Select an adsorbent with a particle size of 1 mm to 1.5 mm, and then conduct a low-temperature skeleton carbonization treatment at 350° C. for 3 hours. Wherein, the raw material components of the adsorbent include: 10 parts by weight of activated carbon and 8 parts by weight of cationic resin.

[0043] S102: The adsorbent after the low-temperature skeleton carbonization treatment is subjected to a medium-temperature impurity removal treatment at 600° C. for 3 hours in an inert gas atmosphere.

[0044] S103: Perform pore-forming treatment at 500° C. on the adsorbent after the treatment of removing impurities at a medium temperature under the action of a mixed gas. Wherein, the mixed gas includes carbon dioxide and water vapor with a volume ratio of 1:1.

[0045] S104: Perform pore activation treatment on the adso...

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Abstract

The invention relates to an adsorbing agent for adsorbing toxins in renal failure patients and a preparation method of the adsorbing agent. The preparation method comprises the following steps: step 101: an adsorbing agent with particle sizes of 1mm-1.5mm is chosen, and then low-temperature skeleton carbonization treatment is performed; step 102: after the low-temperature skeleton carbonization treatment is finished, the obtained adsorbing agent is subjected to medium-temperature impurity removing treatment in an inert gas atmosphere; step 103: after the medium-temperature impurity removing treatment is finished, the obtained adsorbing agent is subjected to pore preparing treatment under the action of mixed gases; and step 104: after the pore preparing treatment is finished, pore activation treatment is performed, after the pore activation treatment is finished, biological compatibility treatment is performed, and therefore the adsorbing agent used for adsorbing the toxins in the renal failure patients is obtained. The adsorbing agent provided in the invention can effectively adsorb intestinal uremia toxin-like substances, so the toxin content in blood is reduced, and the toxicity effect of the toxins entering the blood is reduced; and patient diseases are effectively relieved, meanwhile, the efficiency of dialysis is remarkably improved, the frequency of the dialysis is reduced, and patient life quality is improved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an adsorbent for absorbing toxins in patients with renal failure and a preparation method thereof. Background technique [0002] Patients with renal failure will gradually lose their physiological functions as the kidney function, and the continuous failure will cause the continuous accumulation of toxins in the body and cause more serious complications. Most of the toxins in the body come from the decomposition of food by the intestinal flora, and enter the blood to synthesize toxic substances with corresponding toxins (such as indoxyl sulfate, p-cresol sulfate, creatinine, urea nitrogen, etc.). It is easy to combine with protein in the blood, and it is difficult to remove it by ordinary blood purification methods. In recent years, the number of patients who have to undergo dialysis due to decreased renal function has shown a tendency to gradually increase. [0003] Renal failure inclu...

Claims

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Application Information

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IPC IPC(8): B01J20/20B01J20/30A61K33/44A61P39/00A61P13/12
CPCB01J20/20A61K33/44
Inventor 吴越
Owner 吴越
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