A kind of hydroxypropyl methylcellulose plant hollow capsule

A technology of hydroxypropyl methylcellulose and plant hollow capsules, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations of inactive ingredients, etc., can solve problems such as hindering the development of pharmaceutical dosage forms, and achieve low loss on drying and destructive properties. Small, fast effects

Active Publication Date: 2020-03-17
ANHUI HUANGSHAN CAPSULE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This cannot meet the needs of special drugs that require rapid disintegration, hindering the development of certain drug dosage forms

Method used

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  • A kind of hydroxypropyl methylcellulose plant hollow capsule
  • A kind of hydroxypropyl methylcellulose plant hollow capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1.0kg HPMC is dissolved in the mixed solvent of 80% acetone and 20% water by volume fraction, is mixed with the HPMC solution that mass fraction is 10%, then makes 10% HPMC solution go through into capsule process.

[0023] Capsulation process comprises the following steps:

[0024] 1) Under normal temperature and pressure, put 10% HPMC solution into the sol tank, and keep stirring to make a glue solution. During this process, the sol tank does not need to be heated or vacuumized;

[0025] 2) Filter the glue in the sol tank through the filter bag into the glue barrel, and the glue in the glue barrel will go through color matching, standing, airtight and natural defoaming in order to prepare before dipping in glue;

[0026] 3) Pour the glue after natural defoaming into the glue tray, the temperature of the glue tray is 20-30°C, and then use the mold to dip the glue in the glue tray to prepare the sample. Through the continuous volatilization of the organic solvent aceton...

Embodiment 2

[0029] 1.0kg HPMC is dissolved in the mixed solvent of 90% acetone and 10% water by volume fraction, is mixed with mass fraction and is the HPMC solution of 33%, then makes the HPMC solution of 33% through the capsule-making described in embodiment 1 process.

Embodiment 3

[0031] 1.0kg HPMC is dissolved in the mixed solvent of 85% acetone and 15% water by volume fraction, is mixed with mass fraction and is the HPMC solution of 20%, then makes the HPMC solution of 20% through the capsule-making described in embodiment 1 process.

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Abstract

The invention discloses a hydroxypropyl methyl cellulose plant empty capsule which is prepared through the following method: dissolving hydroxypropyl methyl cellulose in a mixed solvent of an organic solvent and water, preparing a hydroxypropyl methyl cellulose solution with the mass percentage of 10 to 33 percent, and making capsules by using the hydroxypropyl methyl cellulose solution, wherein the organic solvent is ethyl alcohol and / or acetone. The hydroxypropyl methyl cellulose plant empty capsule has the advantages that the capsule is disintegrated fast, is not brittle and has extremely low weight loss on drying; furthermore, according to the preparation method of the capsule, no heating is needed, so that energy consumption is reduced; no gelatinizer is added, so that influence on disintegration due to the gelatinizer is avoided; the capsule is cured and molded only through volatilization of the organic solvent, so that the hydroxypropyl methyl cellulose plant empty capsule is suitable for filling of certain medicines having special requirements.

Description

technical field [0001] The invention relates to the technical field of auxiliary materials in pharmaceutical preparations, in particular to a hydroxypropylmethylcellulose (HPMC) plant hollow capsule. Background technique [0002] Hollow capsules are widely used in the preparation of medicines, health care products and functional foods because of their effective isolation of drug odors and the convenience of taking them. [0003] Most of the existing hollow capsules use animal gelatin as the main raw material, but for special drugs that require rapid disintegration and are prone to cross-linking reactions with proteins, it is not suitable to use gelatin hollow capsules for filling, and HPMC plant hollow capsules need to be used instead of gelatin Empty capsule filling. HPMC is a high molecular polymer obtained by modifying cellulose. It has good mechanical properties, chemical stability and water vapor resistance, and is a good raw material for preparing plant hollow capsule...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/38
CPCA61K9/4816A61K47/38
Inventor 刘松林余超彪柳有成刘国攀
Owner ANHUI HUANGSHAN CAPSULE CO LTD
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