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Magnetic microchip with graphic coding and preparation method and application thereof

A graphic coding and microchip technology, which can be applied to microstructure devices without moving elements, biochemical equipment and methods, bioreactors/fermenters for specific purposes, etc. Achieve the effect of expanding the scope of application, no need for precision equipment, and ensuring accuracy

Active Publication Date: 2017-10-27
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under the commonly used white light lighting conditions, the film system needs to be designed according to the light intensity distribution of the specific light source, and multiple high-precision coating processes are required to achieve the expected reflection effect. The process is difficult and the manufacturing cost is high.

Method used

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  • Magnetic microchip with graphic coding and preparation method and application thereof
  • Magnetic microchip with graphic coding and preparation method and application thereof
  • Magnetic microchip with graphic coding and preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0046] An aspect of the embodiment of the present application provides a method for preparing a magnetic microchip with graphic encoding, comprising:

[0047] providing a transparent substrate layer;

[0048] Covering the thin film formed by magnetic fluid on the transparent substrate layer;

[0049] removing at least a portion of the base carrier fluid from the thin film, thereby at least partially curing the thin film to form a magnetic fluid layer;

[0050] Processing the magnetic fluid layer to form an opaque microstructure that can be used as a graphic code;

[0051] The opaque microstructure is covered with a transparent material to form the magnetic microchip.

[0052] In some preferred embodiments, the preparation method comprises:

[0053] coating the magnetic fluid on the transparent substrate layer to form the thin film,

[0054] Heating removes at least a portion of the base carrier fluid from the thin film, thereby forming the magnetic fluid layer.

[0055] A...

Embodiment 1

[0198] Example 1: Surface modification and functionalization of magnetic microchips

[0199] 1) take figure 2 An appropriate amount of a magnetic microchip prepared by the process shown (for example, 50-5 million pieces, depending on specific needs, and the graphic code on each magnetic microchip can also be adjusted according to actual application requirements) is placed in a 1.5mL microcentrifuge tube.

[0200] 2) Wash twice with 95V / V% ethanol. After each wash, enrich the chip to the bottom of the centrifuge tube with a strong magnet or a special magnetic stand for microcentrifuge tubes, and then use a pipette to remove the supernatant.

[0201] 3) Add 1000 μl of 5 wt% aminosilane APDMS (prepared with 95% ethanol), oscillate sufficiently, sonicate for a while, and shake on a vortex shaker for 30 min.

[0202] 4) According to the method described in step 2), wash the chip 3 times with absolute ethanol.

[0203] 5) Wash once with N,N-dimethylformamide (DMF), and remove t...

Embodiment 2

[0214] Example 2 Multiple detection of nucleic acid markers: Taking high-risk human papillomavirus (HPV) as an example

[0215] Human papillomavirus (human papillomavirus HPV) belongs to the papillomavirus genus of the family Papovaviridae. At present, there are more than 200 subtypes of HPV known, which can be divided into 5 genera (alpha, beta, gamma, mu and nu) and 33 species according to their genome similarity. Alpha HPV mainly infects mucosal epithelial cells, among which more than a dozen HPVs are related to cancer, and are called high-risk HPVs. All current clinical HPV typing methods are based on the detection of HPV nucleic acid in clinical samples. HPV typing detection has important guiding significance in early screening of cervical cancer, postoperative follow-up and follow-up, triage of cytological test results, discovery of high-risk groups, and guidance of HPV vaccine research and use. At present, HPV typing detection methods such as membrane reverse hybridiz...

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Abstract

The invention discloses a magnetic microchip with graphic coding and a preparation method and application thereof. The magnetic microchip comprises the graphic coding and a transparent encapsulating material, wherein the graphic coding includes more than one opaque microstructure, the opaque microstructure mainly comprises colloidal aggregates formed by aggregation of magnetic solid particles, and the adjacent magnetic solid particles are at least isolated by organic molecules and / or inorganic molecules; and the transparent encapsulating material is at least used for packaging the transparent encapsulating material. The magnetic microchip can be manufactured through the micro-processing technique and has high processing precision and high repeatability, the difference between the different batches or the same batch of different individuals in size can be neglected, the magnetic microchip is convenient to use, and the accuracy of a detection result can be effectively guaranteed, so that the analytic quality can be greatly improved.

Description

technical field [0001] The application relates to a suspended microchip, in particular to a magnetic microchip with graphic code and its preparation process. Background technique [0002] Complex life activities are often the result of the synergy of a group of biomolecules as the core executive elements. The fingerprints left by many diseases at the molecular level are often jointly determined by multiple biomarkers. In other words, the "pattern characteristics" presented by multiple marker sets have a stronger correlation with specific physiological and pathological phenomena than a single molecule. It is estimated (Nature, 2011.469(7329): p.156-157), thousands of biomarkers have been recorded in about 150,000 documents, of which there are about 100-100 common markers approved for clinical use. 200 species. Compared with a single biomarker, a biomarker set composed of multiple characteristic molecules can be used in a more comprehensive, accurate and efficient manner fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B81C1/00C12M1/00
CPCB81C1/00103C12Q1/6837C12Q1/6834G01N33/54326G01N33/54346G01N33/553C12Q2563/103C12Q2563/107C12Q2563/143B81B1/00C12Q1/6816G01N33/54393
Inventor 李炯郑克孝陈超
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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