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Method for extracting and purifying total anthraquinone from rheum officinale

A technology of total anthraquinone and rhubarb, applied in the field of medicine, to achieve the effects of rapid extraction, saving production time and stable physical and chemical properties

Inactive Publication Date: 2017-12-01
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main methods for extracting total anthraquinones from rhubarb reported in the literature include reflux method, ultrasonic method, etc., but there is no literature report on the extraction of total anthraquinones from rhubarb by flash extraction.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 50 g of rhubarb coarse powder, extract twice with flash extraction, add 9 times the amount of 50% ethanol for the first time, and add 6 times the amount of 50% ethanol for the second time, and filter the extract with four layers of gauze. Under the above chromatographic conditions, the total anthraquinone content of rhubarb in the extract was determined and the extraction rate and extract rate were calculated.

Embodiment 2

[0026] Weigh 50 g of rhubarb coarse powder, extract twice by flash extraction, add 9 times the amount of 70% ethanol for the first time, and add 6 times the amount of 70% ethanol for the second time, and filter the extract with four layers of gauze. Under the above chromatographic conditions, the total anthraquinone content of rhubarb in the extract was determined and the extraction rate and extract rate were calculated.

Embodiment 3

[0028] Weigh 50 g of rhubarb coarse powder, extract twice by flash extraction, add 9 times the amount of 90% ethanol for the first time, and add 6 times the amount of 90% ethanol for the second time, and filter the extract with four layers of gauze. Under the above chromatographic conditions, the total anthraquinone content of rhubarb in the extract was determined and the extraction rate and extract rate were calculated.

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Abstract

The invention relates to a method for extracting and purifying total anthraquinone from rheum officinale. According to the method, rheum officinale is extracted by adopting a flash extraction method, the extracted solution is concentrated, acid is added into the concentrated solution for hydrolysis, then the hydrolysate is purified by adopting a macroporous adsorption resin, and thus the high-purity free total anthraquinone of rheum officinale is obtained. The preparation process is easy and convenient to operate, and is energy-saving and environmentally friendly, no residue of a toxic solvent exists in the product, and the method is suitable for the industrial production of the free total anthraquinone of rheum officinale by adopting rheum officinale.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a method for extracting and purifying active components of traditional Chinese medicines, in particular to extracting free total anthraquinones from rhubarb and a method for purifying the same. Background technique [0002] Rhubarb is an important commonly used traditional Chinese medicine, which has the effects of purging heat and dredging intestines, cooling blood and detoxifying, removing blood stasis and dredging menstruation. Modern research shows that rhubarb has multiple pharmacological effects such as catharsis, liver protection and gallbladder, antibacterial, antiviral, anti-inflammatory, blood circulation and hemostasis, blood lipid lowering, anti-tumor, etc., while aloe-emodin, rhein, chrysophanol, emodin and The total anthraquinones of rhubarb such as emodin methyl ether are the main active ingredients of rhubarb pharmacological effects. [0003] Patent application number 20141...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K125/00
CPCA61K36/708A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 汤淮波易伟郭林
Owner XIANGTAN UNIV
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