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A multi-substituent naphthalene compound with antibacterial activity in aloe and its preparation method and application

An antibacterial activity, multi-substituted technology, applied in the field of preventing tobacco material liquid from spoilage and multi-substituted naphthalene compounds

Active Publication Date: 2020-08-14
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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This compound has not been reported so far

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  • A multi-substituent naphthalene compound with antibacterial activity in aloe and its preparation method and application
  • A multi-substituent naphthalene compound with antibacterial activity in aloe and its preparation method and application
  • A multi-substituent naphthalene compound with antibacterial activity in aloe and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The aloe samples were from Kunming, Yunnan, and the species was Aloe vera.

[0048] A preparation method of a multi-substituent naphthalene compound with antibacterial activity in aloe, comprising the following steps:

[0049] Step (1), extraction of extract: use dried aloe as raw material, crush aloe to 30-50 meshes, use 80% methanol aqueous solution as extraction solvent, soak and extract 3 times, soak for 24 hours each time, The weight ratio of the extraction solvent used each time to the aloe is 3:1, the combined extract is filtered, and the filtrate is concentrated into an extract;

[0050] Step (2), silica gel column chromatography: the medicinal extract is first dissolved in acetone that is 1.5 times the weight of the medicinal extract, then mixed with 80 mesh silica gel that is 0.8 times the weight of the medicinal extract, and then loaded for column chromatography. The column silica gel is 160 mesh, and the method of packing the silica gel column is dry packin...

Embodiment 2

[0055] The aloe samples were from Kunming, Yunnan, and the species was Aloe vera.

[0056] A preparation method of a multi-substituent naphthalene compound with antibacterial activity in aloe, comprising the following steps:

[0057] Step (1), extraction of extract: use dried aloe as raw material, crush aloe to 30-50 mesh, use methanol as extraction solvent, soak and extract 5 times, soak for 72 hours each time, the weight of each extraction solvent and aloe The ratio is 5:1, the combined extracts are filtered, and the filtrate is concentrated into an extract;

[0058] Step (2), silica gel column chromatography: the medicinal extract is first dissolved with methanol that is 3 times the weight of the medicinal extract, then mixed with 100 mesh silica gel that is 1.2 times the weight of the medicinal extract, and then loaded for column chromatography. The column silica gel is 300 mesh, and the method of silica gel column packing is dry packing, and the weight of silica gel used...

Embodiment 3

[0063] The aloe samples were from Kunming, Yunnan, and the species was Aloe vera.

[0064] A preparation method of a multi-substituent naphthalene compound with antibacterial activity in aloe, comprising the following steps:

[0065] Step (1), extraction of extract: use dried aloe as raw material, crush aloe to 30-50 mesh, use 80% ethanol aqueous solution as extraction solvent, soak and extract 4 times, soak for 48 hours each time, The weight ratio of the extraction solvent used each time to the aloe is 4:1, the combined extract is filtered, and the filtrate is concentrated into an extract;

[0066] Step (2), silica gel column chromatography: the extract is first dissolved in acetone or methanol that is 2.5 times the weight of the extract, then mixed with 90 mesh silica gel that is 0.9 times the weight of the extract, and then loaded for column chromatography, wherein , the packing silica gel is 220 mesh, and the method of silica gel packing is dry packing, and the weight of ...

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Abstract

The invention relates to a multi-substituent-group naphthalene compound with antibacterial activity in aloe as well as a preparation method and an application of the naphthalene compound and belongs to the chemical technical field of natural products. The structural formula of the compound is shown in formula (I) in the description. The compound is prepared from traditional edible and medicinal plant aloe as a raw material through extraction, silica gel column chromatography and high-pressure liquid-phase chromatographic separation and purification. Activity tests prove that the compound has a better antibacterial effect and can effectively inhibit growth of microorganisms in a feed liquid and prolong the expiration date of the tobacco feed liquid after being added to the tobacco feed liquid and has good application prospects.

Description

technical field [0001] The invention belongs to the technical field of natural product chemistry, and in particular relates to a multi-substituent naphthalene compound extracted for the first time from the traditional medicine and food homologous plant aloe. At the same time, the invention also relates to a preparation method of the compound and its application in preventing corruption and deterioration of tobacco material liquid and prolonging the shelf life of tobacco tobacco material liquid. Background technique [0002] Aloe vera is a perennial evergreen herb belonging to the family Liliaceae. It is native to the Mediterranean Sea and Africa. Because it is easy to grow and is an ornamental plant with both flowers and leaves, it is very popular among the public. According to textual research, there are more than 300 varieties of wild aloe vera, and the aloe varieties with medicinal value mainly include: foreign aloe vera, curacao aloe vera, cape aloe vera, yuanjiang aloe ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C45/78C07C49/84A24B15/30
CPCA24B15/303C07C45/78C07C49/84
Inventor 孔维松刘欣李晶耿永勤李雪梅米其利刘志华王明峰者为周敏杨光宇胡秋芬李干鹏
Owner CHINA TOBACCO YUNNAN IND
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