A pharmaceutical composition for increasing the intestinal absorption area of ​​patients with short bowel syndrome

A technology of intestinal absorption and syndrome, applied in the field of medicine, can solve problems such as unclear mechanism of active ingredients, gastrointestinal irritation, and limited therapeutic effect

Inactive Publication Date: 2018-05-15
李昌生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, the exact mechanism of Buzhong Yiqi Decoction in the treatment of short bowel syndrome and its active ingredients are still unclear, and the oral preparation of Buzhong Yiqi Decoction with complex components will be irritating to the gastrointestinal tract of patients with short bowel syndrome. thereby limiting its therapeutic effect

Method used

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  • A pharmaceutical composition for increasing the intestinal absorption area of ​​patients with short bowel syndrome
  • A pharmaceutical composition for increasing the intestinal absorption area of ​​patients with short bowel syndrome
  • A pharmaceutical composition for increasing the intestinal absorption area of ​​patients with short bowel syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Oral solution for increasing the intestinal absorption area of ​​patients with short bowel syndrome and its preparation process

[0035] Prescription: Astragalus 60kg, Atractylodes macrocephala 20kg, Angelica 20kg, Chenpi 12kg, Ginger 12kg, Tsaoguo 6kg, Peach Grass 3kg.

[0036] Preparation Process:

[0037] 1) Pulverization: Take the prescribed amount of Astragalus membranaceus, Atractylodes macrocephala, Angelica sinensis, Tangerine peel, ginger, Tsaoguo, and Peachgrass, and pulverize them separately, pass through a 40-mesh sieve, and mix to obtain medicinal material powder;

[0038] 2) Extraction: Put the medicinal powder obtained in step 1) into the volatile oil extractor, add water to the medicinal powder at a ratio of 12 ml of water per gram of medicinal powder, soak for 4 hours to swell, and then use steam distillation to extract relative density below 1.0 For the volatile oil component, the extraction temperature is 75°C, the extraction time is 6 hour...

Embodiment 2

[0041] Example 2 Oral solution for increasing the intestinal absorption area of ​​patients with short bowel syndrome and its preparation process

[0042] Prescription: Astragalus 100kg, Atractylodes macrocephala 40kg, Angelica 30kg, Chenpi 15kg, Ginger 15kg, Tsaoguo 5kg, Prunus chinensis 2kg.

[0043] Preparation Process:

[0044] 1) Pulverization: Take the prescribed amount of Astragalus membranaceus, Atractylodes macrocephala, Angelica sinensis, Tangerine peel, ginger, Tsaoguo, and Peachgrass, and pulverize them separately, pass through a 40-mesh sieve, and mix to obtain medicinal material powder;

[0045] 2) Extraction: Put the medicinal powder obtained in step 1) into the volatile oil extractor, add water to the medicinal powder at a ratio of 12 ml of water per gram of medicinal powder, soak for 4 hours to swell, and then use steam distillation to extract relative density below 1.0 For the volatile oil component, the extraction temperature is 75°C, the extraction time is ...

Embodiment 3

[0048] Example 3 Oral solution for increasing the intestinal absorption area of ​​patients with short bowel syndrome and its preparation process

[0049] Prescription: Astragalus 110 kg, Atractylodes macrocephala 40 kg, angelica 50 kg, tangerine peel 18 kg, ginger 10 kg, tsaoguo 4 kg, and chrysanthemum 5 kg.

[0050] Preparation Process:

[0051] 1) Pulverization: Take the prescribed amount of Astragalus membranaceus, Atractylodes macrocephala, Angelica sinensis, Tangerine peel, ginger, Tsaoguo, and Peachgrass, and pulverize them separately, pass through a 40-mesh sieve, and mix to obtain medicinal material powder;

[0052] 2) Extraction: Put the medicinal powder obtained in step 1) into the volatile oil extractor, add water to the medicinal powder at a ratio of 12 ml of water per gram of medicinal powder, soak for 4 hours to swell, and then use steam distillation to extract relative density below 1.0 For the volatile oil component, the extraction temperature is 75°C, the ext...

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Abstract

The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for increasing the intestinal absorption area of ​​patients with short bowel syndrome. The pharmaceutical composition is prepared from pharmaceutically acceptable excipients and Astragalus, Atractylodes Rhizome, Angelica, Tangerine Peel, Ginger, Tsaoguo, and Prunus chinensis. The active ingredients of peach grass are preferably volatile oil components. Its formulation is preferably an oral liquid formulation. The composition can significantly increase the intestinal absorption area and gland quantity of the short bowel syndrome rat model, and improve the intestinal absorption function of the model rat.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for increasing the intestinal absorption area of ​​patients with short bowel syndrome. Background technique [0002] Short bowel syndrome (Short bowel syndrome) refers to that after extensive resection or desertion of the small intestine due to various reasons, the effective nutrient absorption area of ​​the intestine is significantly reduced, which leads to the inability of the remaining functional intestine to maintain the nutritional needs of patients or infants and children. The growth demand makes the patients suffer from symptoms mainly including diarrhea, acid-base / water / electrolyte disorders, and various nutrient absorption and metabolism disorders. The severity and prognosis of the disease depend on factors such as the length and location of the residual intestine, whether the ileocecal valve and colon are preserved, and whether the intest...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P1/00A61P1/14A61P1/08A61P1/12
Inventor 李昌生张晶孙铁峰高继友
Owner 李昌生
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