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New application of traditional Chinese medicine fennel

A technology of cumin and traditional Chinese medicine, which is applied to the new application field of traditional Chinese medicine cumin, can solve the problems of low efficiency, lack of practical value, inability to effectively overcome the natural barrier effect of the intestinal tract and the like

Active Publication Date: 2012-09-19
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the stability of protein drugs has been improved, it still cannot effectively overcome the natural barrier function of the intestinal tract. The absorption efficiency of protein drugs into the blood is very low, and the bioavailability usually does not exceed 1%. Sodium alginate drug-loaded microspheres Use alone still lacks practical value

Method used

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  • New application of traditional Chinese medicine fennel
  • New application of traditional Chinese medicine fennel
  • New application of traditional Chinese medicine fennel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Preparation of fennel sausage tract absorption enhancer decoction: The traditional Chinese medicine fennel was decocted according to the conventional method to obtain 0.3g / ml (dry weight / liquid) decoction, and the gavage dose was 0.5ml decoction / head Mice.

Embodiment 2

[0018] Example 2: Preparation of lysozyme sodium alginate microspheres: prepared by W / O emulsification-ion crosslinking method according to literature reference. The main preparation parameters are: sodium alginate concentration 5% (W / V), lysozyme concentration 1% (W / V), fructose concentration 2% (W / V). Properties of drug-loaded microspheres: spherical shape, smooth and round surface, less adhesion, no damage, good dispersion and stability, average particle size (9.45±3.1) μm, encapsulation efficiency 57.6%, drug loading It was 7.2%, and the enzyme activity was 76.1% of the initial lysozyme activity.

Embodiment 3

[0019] Example 3: Oral mode and dosage: mice were simultaneously gavage with fennel decoction and drug-loaded sodium alginate microspheres, once a day, the dosage of fennel decoction was 0.5 ml per mouse. The dose of drug-loaded sodium alginate microspheres is 14 mg / mouse.

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Abstract

The invention relates to a new application of traditional Chinese medicine fennel. Fennel can promote intestinal absorption of lysozyme protein in the orally-taken sodium alginate microspheres so as to increase the lysozyme blood concentration and remarkably improve the bioavailability of lysozyme.

Description

Technical field [0001] The invention relates to a new use of traditional Chinese medicine fennel, in particular to the application of traditional Chinese medicine fennel as an intestinal absorption enhancer in improving the efficiency of oral lysozyme intestinal absorption. Background technique [0002] Lysozyme (Lysozyme) is a protein-based biological enzyme with antibacterial, antiviral, immune regulation, hemostasis, swelling, and tissue repair functions. It is an important non-specific immune factor and has a wide range of applications in the medical field. Applications. [0003] The existing oral lysozyme drugs are mainly lozenges, powders and enteric-coated capsules. Their drug targets are mainly to directly act on pathogenic bacteria in the gastrointestinal tract, or to be used as drugs in vitro. The efficiency of in vivo absorption into the blood is very low. The use is very limited. Intravenous injection can effectively increase the blood concentration of lysozyme, an...

Claims

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Application Information

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IPC IPC(8): A61K36/23A61K38/47A61P37/02A61P31/04A61P31/12A61P43/00
Inventor 陈宇光何佳郭敏苏洁戴小峰
Owner SHANGHAI UNIV
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