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Triterpenoid saponin pharmaceutical compound, preparations and application thereof

A technology of pharmaceutical compounds and triterpene saponins, applied in drug combinations, steroids, organic chemistry, etc., can solve the problems of no anti-tumor drug reports, etc., and achieve a significant inhibitory effect

Inactive Publication Date: 2018-01-26
YUNNAN BOTANEE BIO TECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no triterpene saponins with anti-tumor activity have been found from the branches and leaves of Camellia yunnanensis, and there are no reports of anti-tumor drugs made from them as active ingredients

Method used

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  • Triterpenoid saponin pharmaceutical compound, preparations and application thereof
  • Triterpenoid saponin pharmaceutical compound, preparations and application thereof
  • Triterpenoid saponin pharmaceutical compound, preparations and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Preparation and structural identification of antitumor active triterpene saponins from Camellia yunnanensis:

[0022] The branches and leaves of Camellia reticulata were collected from Yunnan and cultivated in various places, dried and pulverized (5.0 kg), extracted three times with 75% ethanol under reflux, combined extracts, concentrated and recovered under reduced pressure to obtain a crude extract. After the crude extract was dissolved in warm water, n-butanol was added for extraction three times, and the n-butanol layer was concentrated under reduced pressure to obtain 500 g of n-butanol extract. Mix the sample with 700g of silica gel (80-100 mesh), pack 2kg of silica gel (200-300 mesh) into the column, and perform gradient elution in the chloroform-methanol-water system (1:0:0→100:1:0→40:1: 0→20:1:0→10:1:0→8:2:0.2→7:3:0.5→1:1:0.5). Detected with TCL thin-layer plate, and finally got 3 parts: Fr.1 (90g), Fr.2 (110g) and Fr.3 (70g). Fr.2 Repeated silica gel column...

Embodiment 2

[0049] The triterpene saponin pharmaceutical compound preparation is:

[0050] Yunnan camellia triterpene saponin compound 1 or compound 2 or compound 3 or compound 4 or compound 5 or compound 6 or compound 7 as a single compound and lactose or starch, or seven compounds are combined with excipient lactose or starch, Be mixed and make powder in the ratio of 9:1 by weight;

[0051] Yunnan camellia triterpene saponin compound 1 or compound 2 or compound 3 or compound 4 or compound 5 or compound 6 or compound 7 is combined with dextrin, or lactose, or starch, or magnesium stearate, or seven compounds Then mix it with dextrin, or lactose, or starch, or magnesium stearate in a ratio of 5:1 or 8:1 or 10:1 by weight, then granulate and tablet;

[0052] Yunnan camellia triterpene saponin compound 1 or compound 2 or compound 3 or compound 4 or compound 5 or compound 6 or compound 7 is combined with dextrin, or lactose, or starch, or magnesium stearate, or seven compounds Finally, wit...

Embodiment 3

[0057] (1) The cytotoxic activity test method of compound 1-7 of the present invention:

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PUM

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Abstract

Belonging to the technical field of drugs, the invention relates to a triterpenoid saponin pharmaceutical compound, preparations and application thereof. The triterpenoid saponin pharmaceutical compound includes Camellia reticulate triterpenoid saponin compound 1 or compound 2 or compound 3 or compound 4 or compound 5 or compound 6 or compound 7. Single compound of the compounds 1-7, or a combination of the 7 compounds, and dextrin, or lactose, or starch, or magnesium stearate, or water for injection are prepared in a weight ratio of 9:1, 1:5-1:10, 5:1, 3:1 by a conventional preparations. Thetriterpenoid saponin compound can be applied to preparation of pharmaceutical preparations for treatment or prevention of leukemia, lung cancer, liver cancer, breast cancer and colon cancer. The triterpenoid saponin compound provided by the invention has significant inhibitory activity on the 5 tumor strains of leukemia, lung cancer, liver cancer, breast cancer and colon cancer, and provides new drugs and new ways for comprehensive utilization of Camellia reticulate and development of drugs for treatment and prevention of the cancers.

Description

technical field [0001] The invention relates to a triterpene saponin pharmaceutical composition and its preparation and application, belonging to the technical field of medicines. Background technique [0002] Yunnan Camellia (Camellia reticulata Lindl.) is an evergreen tree plant of the family Theaceae Camellia, also known as Yunnan Camellia and Nanshan Camellia, shrubs to small trees, sometimes up to 15 meters, with glabrous twigs. Leaves broadly elliptic, apex sharp or acute, base cuneate or round, upper part dark green and shiny after drying, lower part dark brown, glabrous; petiole 8-13 mm long, glabrous; flowers terminal, red , sessile. It is mainly distributed in Yunnan Province of my country, and has a cultivation history of more than 1,000 years. It is the most famous one among the "Eight Famous Flowers" in Yunnan. It is sweet in taste and cool in nature. Return liver, stomach, large intestine channel. It has the effects of cooling blood and stopping bleeding, d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J17/00A61K31/704A61P35/00A61P35/02
Inventor 刘海洋何黎郭振宇倪伟马骁
Owner YUNNAN BOTANEE BIO TECH GRP CO LTD
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