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A kind of pharmaceutical composition and application for preventing or treating ischemia/reperfusion injury

A technology of reperfusion injury and composition, which is applied in the field of biomedicine, can solve the problems of no prevention and treatment of ischemia, etc., and achieve the effects of reducing cerebral ischemia/reperfusion injury, enhancing compliance, and less irritation

Active Publication Date: 2020-04-07
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is no such treatment and treatment
At present, there is no report on the combined application of Enlikagen and Ponatinib in the prior art, especially the combined application of the two in the prevention and treatment of ischemia / reperfusion injury

Method used

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  • A kind of pharmaceutical composition and application for preventing or treating ischemia/reperfusion injury
  • A kind of pharmaceutical composition and application for preventing or treating ischemia/reperfusion injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] In the following, the amounts of enlicasen and ponatinib are expressed as equal amounts of enlicasen and ponatinib in free form without salt formation.

[0019] Animal experiment: the protective effect of the combination of Enlikagen and ponatinib on ischemic stroke

[0020] Implemented drugs: sodium carboxymethylcellulose (CMC-Na) was purchased from Shanghai Shanpu Chemical Co., Ltd.

[0021] The combination of Enlicagen and Ponatinib was made into a suspension using 0.5% sodium carboxymethylcellulose (CMC-Na) as a vehicle.

[0022] Experimental animals: 48 healthy male SD rats with a body weight of 250-300 g. The experimental animals were fed for one week in an environment with a temperature of 25° C., a relative humidity of 60%, free access to drinking water, and regular and quantitative amounts, and then administered orally according to the requirements of each group in the experiment.

[0023] Modeling method: The rat model of cerebral ischemia / reperfusion injury...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for preventing or treating ischemia / reperfusion injury. Active components of the pharmaceutical composition are composed of Emricasan and Ponatinibat the weight ratio of 1: (0.25-10). The pharmaceutical composition of the present invention can cooperatively prevent and treat ischemic stroke and can remarkably mitigate ischemia / reperfusion injury.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to a pharmaceutical composition for preventing or treating ischemia / reperfusion injury and its application. Background technique [0002] Ischemic stroke is a common and frequently-occurring disease that seriously endangers human health. It has become the first cause of disability and the third cause of death in the world. The incidence of ischemic stroke accounts for about 70-80% of cerebrovascular diseases. [0003] Cerebral ischemic injury is related to multiple mechanisms such as excessive formation of free radicals, excitatory amino acid toxicity, intracellular calcium overload, and inflammatory response. Regardless of the mechanism, the final outcome will lead to neuronal cell death, functional destruction, and cerebral infarction form. There are two main ways of cell death, apoptosis and necrosis. Neuronal apoptosis and necrosis exist simultaneously in cerebral ischemi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5025A61K31/197A61P9/10
CPCA61K31/197A61K31/5025A61K2300/00
Inventor 罗秀菊彭军田静刘斌彭靖杰李嘉辉付四海
Owner CENT SOUTH UNIV
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