Slightly irritant Lugol's solution and preparation method thereof

An irritant and Lugol's technology, which is applied in the field of compound iodine solution and its preparation, can solve the problems of high oral irritation and serious injury to people allergic to iodine, and achieve the effect of alleviating allergic reactions and improving the comfort of taking medicine

Inactive Publication Date: 2018-02-09
铜陵市东方矿冶机械有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it still has the disadvantages of greater irritation to the oral cavity and greater damage to people allergic to iodine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: slightly stimulating Lugol's solution, which comprises by weight: 2 parts of iodine, 4 parts of potassium iodide, 40 parts of deionized water, 10 parts of glucose and 3 parts of Shuanghuanglian.

[0012] The preparation method of slightly irritating Lugol's solution comprises the following steps: placing 4 parts of potassium iodide in a container, adding 2 / 3 of all deionized water and stirring to dissolve it, raising the temperature to 50° C. for 4 minutes to form a potassium iodide solution ; Mix 2 parts of iodine with the remaining amount of deionized water and put it into a centrifuge to centrifuge at a speed of 300r / min for 10min, then add 3 parts of Shuanghuanglian to the centrifuge, and centrifuge at a speed of 200r / min for 5min to form a suspension solution, add 10 parts of glucose to the potassium iodide solution, stir evenly, freeze to form a jelly within 2 minutes, add the jelly into the suspension, heat to 30°C and keep it warm.

Embodiment 2

[0013] Embodiment 2: slightly stimulating Lugol's solution, which comprises by weight: 3 parts of iodine, 6 parts of potassium iodide, 60 parts of deionized water, 15 parts of glucose and 5 parts of Shuanghuanglian.

[0014] The preparation method of slightly irritating Lugol's solution comprises the following steps: placing 6 parts of potassium iodide in a container, adding 2 / 3 of all deionized water and stirring to dissolve it, raising the temperature to 55° C. for 5 minutes to form a potassium iodide solution ; Mix 3 parts of iodine with the remaining amount of deionized water and put it into a centrifuge to centrifuge at a speed of 350r / min for 15 minutes, then add 5 parts of Shuanghuanglian to the centrifuge, and centrifuge at a speed of 250r / min for 7 minutes to form a suspension solution, add 15 parts of glucose to the potassium iodide solution, stir evenly, freeze to form a jelly within 3 minutes, add the jelly into the suspension, heat to 35°C and keep it warm.

Embodiment 3

[0015] Example 3: slightly irritating Lugol's solution, which includes by weight: 4 parts of iodine, 8 parts of potassium iodide, 80 parts of deionized water, 20 parts of glucose and 6 parts of Shuanghuanglian.

[0016] The preparation method of slightly irritating Lugol's solution comprises the following steps: placing 8 parts of potassium iodide in a container, adding 2 / 3 of all deionized water and stirring to dissolve it, raising the temperature to 60° C. for 6 minutes to form a potassium iodide solution ; Mix 4 parts of iodine with the remaining amount of deionized water and put it into a centrifuge to centrifuge at a speed of 400r / min for 20min, then add 6 parts of Shuanghuanglian to the centrifuge, and centrifuge at a speed of 300r / min for 10min to form a suspension solution, add 20 parts of glucose to the potassium iodide solution, stir evenly, and freeze to form a jelly within 4 minutes, add the jelly into the suspension and heat to 40°C, then keep it warm.

[0017] In...

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PUM

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Abstract

The invention discloses a slightly irritant Lugol's solution and a preparation method thereof. The slightly irritant Lugol's solution is prepared from components in parts by weight as follows: 2-4 parts of iodine, 4-8 parts of potassium iodide, 40-80 parts of deionized water, 10-20 parts of glucose and 3-6 parts of Shuanghuanglian. The slightly irritant Lugol's solution has the beneficial effectsthat by means of addition of glucose and Shuanghuanglian to the traditional Lugol's solution, on one hand, anaphylaxis of a patient with iodine allergy can be relieved, on the other hand, the irritantaction of the Lugol's solution on the oral cavity can be relieved while the bacteria killing and inhibiting effect of the Lugol's solution is guaranteed, and the drug taking comfort of the patient isimproved.

Description

technical field [0001] The invention relates to the field of medicaments, in particular to a compound iodine solution and a preparation method thereof. Background technique [0002] Compound iodine solution, also known as Lugol's solution, is mainly composed of 4.5% to 5.5% iodine, 9.5% to 10.5% potassium iodide, and a regulator of thyroid function. Small doses of iodine are used as raw materials for iodine supply to synthesize thyroxine, correct the excessive secretion of thyrotropin by the pituitary gland, and shrink the enlarged thyroid gland, which can treat endemic goiter. Large doses of iodine have an anti-thyroid effect, promoting the reduction of blood vessels in the thyroid gland and the hardening of glandular tissue. It is used for prevention and treatment of endemic goiter caused by iodine deficiency, relief of exophthalmos symptoms of hyperthyroidism, rescue of hyperthyroid crisis and preoperative preparation for thyroid surgery. However, due to its strong bact...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K9/08A61K47/26A61K33/18A61P5/16A61P31/04A61P31/10
CPCA61K33/18A61K9/0053A61K9/08A61K36/355A61K36/539A61K36/634A61K47/26A61K2300/00
Inventor 侯世祥
Owner 铜陵市东方矿冶机械有限责任公司
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