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Diabetes treatment product as well as preparation and application thereof

A technology for diabetes and products, applied in the field of drug research and development, can solve problems such as GLP-1 instability and achieve the effect of preventing absorption

Active Publication Date: 2018-02-13
徐天宏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many drug developments focus on the use of GLP-1 to treat diabetes, obesity and other diseases, but the natural GLP-1 in the human body is very unstable and can be degraded by dipeptidyl peptidase IV (DPP IV), with a half-life of only 1 to 2 minutes

Method used

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  • Diabetes treatment product as well as preparation and application thereof
  • Diabetes treatment product as well as preparation and application thereof
  • Diabetes treatment product as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] In this embodiment, a diabetes treatment product containing component B is prepared. The component B is an oral positioning release formulation that is released at the end of the ileum and colon, and the oral positioning release formulation contains nutrients.

[0097] In this embodiment, referring to the prior art, an oral positioning release formulation that is positioned and released at the terminal ileum and colon is prepared, and nutrients are positioned at the terminal ileum and colon for release. Oral localized release preparations prepared in the terminal ileum and colon for localized release are in the prior art. For example, reference may be made to the technology described in the invention patent application No. 201480003932.X.

[0098] Specifically, in this embodiment, thiolated chitosan (Thiolated Chitosan, TC) is used as a carrier material to prepare thiolated chitosan microspheres. Then, the nutrient components are dissolved or dispersed in the thiolated chito...

Embodiment 2

[0121] In this example, a diabetes treatment product containing component A and component B is prepared. The component B is an oral positioning release formulation that is released at the terminal ileum and colon (same as in Example 1); component A is an oral duodenum An intestinal positioning release preparation containing an intestinal mucosal viscous polymer in the oral duodenal positioning release preparation.

[0122] In this example, referring to the prior art, an oral duodenal positioning release formulation is prepared, and the intestinal mucosal viscous polymer is positioned to the duodenum for release, and the intestinal mucosal viscous polymer adheres to the duodenal mucosa. Shield and prevent the absorption of duodenum.

[0123] Specifically, in this embodiment, thiolated chitosan (Thiolated Chitosan, TC) is used as the intestinal mucosal viscous polymer to prepare thiolated chitosan microspheres. Then, the thiolated chitosan microspheres are wrapped in hydroxypropyl m...

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Abstract

The invention belongs to the field of research and development of drugs, and particularly relates to a diabetes treatment product as well as preparation and application thereof. The diabetes treatmentproduct contains an orally-taken locating release preparation which is located and released at terminal ileum and colon, and the orally-taken locating release preparation contains nutritional ingredients. Through broad and in-depth study, the condition that the diabetes treatment product can be adopted for enabling the nutritional ingredients to be located to the terminal ileum or the colon to bereleased, or combining simultaneously to enable an intestinal mucosa viscous polymer to be located to duodenum to be released, so as to adhere the intestinal mucosa viscous polymer to duodenum mucosato form a shield to prevent the absorptive action of the duodenum is discovered for the first time, and the diabetes treatment product can more perfectly simulate and achieve the effect of metabolicsurgery.

Description

Technical field [0001] The invention belongs to the field of drug research and development, and specifically relates to a diabetes treatment product and its preparation and application. Background technique [0002] At present, type 2 diabetes affects the health of more than 415 million people in the world. What is more serious is that the mortality rate related to diabetes will increase by more than 50% in the next 10 years. According to data released by my country’s Health and Family Planning Commission, the current prevalence of type 2 diabetes in adults with diabetes in China has reached 11.4%, soaring to the first place in the world, reaching 140 million people. Diabetes causes complications such as heart disease, kidney failure, The incidence of blindness, foot ulcers, etc. is also on the rise. In addition, 20% of the population in my country is in the pre-diabetes stage, and the glucose metabolism of these people has been abnormal. [0003] Type 2 diabetes mainly ranges fro...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K9/20A61K31/19A61K31/198A61K31/575A61K47/32A61K47/38A61K47/36A61P3/10A61P3/04A61P3/00A61P15/08
CPCA61K9/0002A61K9/0053A61K9/2081A61K9/5026A61K9/5036A61K9/5042A61K9/5073A61K31/19A61K31/198A61K31/575A61K2300/00
Inventor 徐天宏
Owner 徐天宏
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