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Application of N-acetylated chitohexaose for inhibiting proliferation of tumor cells

A technology for tumor cell proliferation and chitohexaose transformation, which is applied in the application field of N-acetylated chitohexaose to inhibit tumor cell proliferation, and can solve the problems of inhibition, effective treatment of tumors without fundamental breakthrough, recurrence and other problems.

Active Publication Date: 2018-03-06
南通中国科学院海洋研究所海洋科学与技术研究发展中心 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] For a long time, there has been no fundamental breakthrough in the effective treatment of tumors in clinical medicine. The conventional treatment methods are surgery, radiotherapy, and chemotherapy. Although they can play a certain role, they often cause malignant problems such as metastasis and recurrence, and eventually lead to exhaustion of life
At present, although most antineoplastic drugs have a certain inhibitory and killing effect on tumor cells, they often also affect the metabolism of normal cells, causing rapid weight loss, and the thymus and spleen are significantly reduced, showing that antineoplastic drugs inhibit the immune function of the body.

Method used

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  • Application of N-acetylated chitohexaose for inhibiting proliferation of tumor cells
  • Application of N-acetylated chitohexaose for inhibiting proliferation of tumor cells
  • Application of N-acetylated chitohexaose for inhibiting proliferation of tumor cells

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Embodiment Construction

[0023] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the content of the present invention, those skilled in the art may make various changes or modifications to the present invention, and these equivalent forms also fall within the scope of the present invention.

[0024] An application of N-acetylated chitosan to inhibit the proliferation of tumor cells, the sugar residue at the reducing end of the N-acetylated chitosan is N-acetylglucosamine, and at the same time retains the second sugar from the reducing end The residue should be the structure of glucosamine, and the structural formula of the N-acetylated chitosan is as shown in formula I:

[0025]

[0026] In the N-acetylated chitohexaose, N-acetylation at the redu...

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Abstract

The invention discloses an application of N-acetylated chitohexaose for inhibiting the proliferation of tumor cells. The sugar residue at the reducing end of the N-acetylated chitohexaose is N-acetylglucosamine and the sugar residue at the 2th site from the reducing end has a glucosamine structure. A natural non-toxic chitosan oligosaccharide is used as a lead compound and through selective N-acetylation and ion exchange chromatography separation, a specific structural component of N-acetylated chitohexaose having strong anti-tumor activity is screened. The N-acetylated chitohexaose has a great significance to develop efficient and low-toxic marine anti-tumor innovative drugs.

Description

technical field [0001] The invention relates to the field of marine chemical engineering, in particular to an application of N-acetylated chitosan to inhibit tumor cell proliferation. Background technique [0002] For a long time, there has been no fundamental breakthrough in the effective treatment of tumors in clinical medicine. The conventional treatment methods are surgery, radiotherapy, and chemotherapy. Although they can play a certain role, they often cause malignant problems such as metastasis and recurrence, and eventually lead to The exhaustion of life. At present, although most anti-tumor drugs have a certain inhibitory and killing effect on tumor cells, they often also affect the metabolism of normal cells, causing rapid weight loss, and the thymus and spleen are significantly reduced, showing that anti-tumor drugs inhibit the immune function of the body. Therefore, finding natural antitumor drugs without toxic and side effects is an urgent problem to be solved ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61P35/00A61P35/02
CPCA61K31/722
Inventor 李克成李鹏程邢荣娥刘松于华华陈晓琳秦玉坤李荣锋王雪芹
Owner 南通中国科学院海洋研究所海洋科学与技术研究发展中心
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