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Construction method of compound traditional Chinese medicine samples with chemical composition content difference

A technology of differential samples and compound traditional Chinese medicine, which is applied in measurement devices, scientific instruments, material separation, etc., to achieve the effect of less difficulty and high applicability

Inactive Publication Date: 2018-03-06
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to establish a sample construction method for compound Chinese medicine with differences in chemical composition content, and provide innovative method support for solving the problem of analysis of the connotation of compound Chinese medicine prescriptions and identification of active ingredient groups

Method used

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  • Construction method of compound traditional Chinese medicine samples with chemical composition content difference
  • Construction method of compound traditional Chinese medicine samples with chemical composition content difference
  • Construction method of compound traditional Chinese medicine samples with chemical composition content difference

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Compound Xueshuantong Capsules Composed of Radix Notoginseng, Danshen, Astragalus, and Scrophulariaceae with Different Chemical Composition Content Sample Construction

[0017] 1. Materials

[0018] (1) Instruments and reagents: CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd., KQ-250DE), vortex oscillator (Scientific Industries Vortex-Genie 2), rotary evaporator (Shanghai Yarong Biochemical Instrument Factory, RE-5205 / RE-2000B), oven (Millipore, UFB400), ultrapure water device (Millipore Simplicity), electronic analytical balance (Sartorius), refrigerator (Siemens), beaker, Erlenmeyer flask, distillation flask and other glass instruments; methanol, acetonitrile, Phosphoric acid (chromatographically pure), ultrapure water.

[0019] (2) Medicinal materials: Panax notoginseng, batch number: 161110; Danshen, batch number: 161110; Astragalus, batch number: 161110; Scrophulariaceae, batch number: 161110, provided by Guangdong Zhongsheng Pharmaceut...

Embodiment 2

[0034] Example 2: The sample construction of Naoshuantong Capsules composed of Puhuang, Chishao, Curcuma, Gastrodia elata, and Loulu with different chemical composition content

[0035] 1. Materials

[0036] (1) Instruments and reagents: CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd., KQ-250DE), vortex oscillator (Scientific Industries Vortex-Genie 2), rotary evaporator (Shanghai Yarong Biochemical Instrument Factory, RE-5205 / RE-2000B), oven (Millipore, UFB400), ultrapure water device (Millipore Simplicity), electronic analytical balance (Sartorius), refrigerator (Siemens), beaker, Erlenmeyer flask, distillation flask and other glass instruments; methanol, acetonitrile, Tetrahydrofuran, phosphoric acid (chromatographically pure), ultrapure water.

[0037] (2) Medicinal materials: Puhuang, batch number: 160604; Chishao, batch number: 160604; Curcuma, batch number: 160604; Gastrodia elata, batch number: 160604; Provided by Guangdong South China Pharmaceutical...

Embodiment 3

[0051] Example 3: Kouyanqing Granules Consisting of Five Flavors of Mountain Yinhua, Scrophulariaceae, Radix Asparagus, Ophiopogon japonicus, and Licorice with Different Chemical Composition Content Sample Construction

[0052] 1. Materials

[0053] (1) Instruments and reagents: CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd., KQ-250DE), vortex oscillator (Scientific Industries Vortex-Genie 2), rotary evaporator (Shanghai Yarong Biochemical Instrument Factory, RE-5205 / RE-2000B), oven (Millipore, UFB400), ultrapure water device (Millipore Simplicity), electronic analytical balance (Sartorius), refrigerator (Siemens), beaker, Erlenmeyer flask, distillation flask and other glass instruments; methanol, acetonitrile, Formic acid (mass spec pure), ultrapure water.

[0054] (2) Medicinal materials: Sanyinhua, batch number: 160815; Scrophulariaceae, batch number: 160815; Asparagus, batch number: 160815; The above medicinal materials were provided by Guangzhou Hutchi...

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Abstract

The invention discloses a construction method of compound traditional Chinese medicine samples with chemical composition content difference and further discloses a construction and detection method ofdifference samples of a compound thrombolysis capsule, a cerebral thrombolysis capsule and kouyanqing granules. The method comprises the following steps: taking each of components of a compound traditional Chinese medicine as an experimental factor, wherein the variation range of non-sovereign drug components is from 0% to 2 times of the content of the prescription, and the variation range of a sovereign drug is that the sum of the contents of the non-sovereign drug components are subtracted from 100%; determining an appropriate level figure with the ranges. All the components and the feedingcapacity are uniformly arranged; multiple groups of difference samples are prepared according to a standard technological process; fingerprint spectrums of all groups of difference samples are made,and the difference among the difference samples is verified by adopting a clustering method.

Description

technical field [0001] The invention relates to a method for constructing differential samples of compound traditional Chinese medicines. Background technique [0002] The overall curative effect of compound Chinese medicine is the result of the interaction between the active ingredient group and multiple targets. When the active ingredient group changes, its efficacy will also change accordingly. On this basis, according to the correlation between the ingredients and the efficacy, it is possible to distinguish and analyze the active ingredient groups in traditional Chinese medicine. Through the correlation between the content changes of various medicinal materials in compound Chinese medicine and the changes in their biological activities, the contribution, function and interaction of each medicinal material to the efficacy can be clarified, and the connotation of the composition of compound Chinese medicine can be scientifically analyzed. [0003] In order to better stud...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 姚宏亮刘宏苏薇薇李沛波吴忠王永刚彭维
Owner SUN YAT SEN UNIV
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