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Development of dietary therapy in cancer

A cancer, high-fat diet technology, applied in the field of high-fat diet such as low-sugar high-fat diet in advanced cancer treatment, composition or combination of diet therapy, and composition or combination of prevention or treatment of cancer, can solve the problem of large side effects, no problem Significant improvement in prognosis, etc.

Inactive Publication Date: 2018-04-17
OSAKA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In recent years, early detection of resectable gastric cancer, colorectal cancer and other tumors has significantly improved the life prognosis of patients. However, pancreatic cancer, gallbladder cancer, lung cancer, etc. are mostly discovered in the late stage of cancer, and sometimes they are used at the same time. Chemotherapy and radiotherapy that damage QOL have not significantly improved the prognosis (National Cancer Surveillance Statistics 2000-2002 Survival Rate Report, National Cancer Research Center)

Method used

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  • Development of dietary therapy in cancer
  • Development of dietary therapy in cancer
  • Development of dietary therapy in cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0199] Next, preferred embodiments of the present invention will be described. It should be understood that the embodiments provided below are provided for better understanding of the present invention, and the scope of the present invention is not limited to the following descriptions. Therefore, it is obvious that those skilled in the art can make appropriate changes within the scope of the present invention with reference to the contents of this specification. In addition, it should be understood that the following embodiments of the present invention may be used alone or in combination.

[0200] (Cancer Treatment Based on High Fat Diet)

[0201] In one aspect, the present invention provides a composition for treating cancer comprising a high fat diet, or a combination thereof. In the present invention, by introducing a high-fat diet, it is possible to treat a wide range of types and degrees of cancer, including advanced cancers that are currently extremely difficult to r...

Embodiment 1

[0247] The effectiveness of the ketogenic formula against cancer was evaluated using a colon26 cell-transplanted cancer model in mice.

[0248] (material and method)

[0249] Colon26 cells (5x10) of the large intestine (colon) cancer cell line were subcutaneously transplanted into the flanks of 30 male CDF1 mice aged 7 weeks 5 indivual). After transplantation, the mice were divided into a control group and a KF group (ketogenic formula group) with 10 mice as a group. The animals in the control group were fed refined feed AIN-93G, and the animals in the KF group were fed the ketogenic formula between the Colon26 cell transplantation and 21 days. The ketogenic formula used 817-B provided by Meiji Co., Ltd. The composition of the ketogenic formulation (817-B) is shown in Table 2A below. The energy balance of the main components of each sample is shown in Table 2B.

[0250] [Table 2A]

[0251]

[0252] [Form 2B]

[0253] Table 2B: Feed Composition (Energy Balance)

[02...

Embodiment 2

[0259] To test the ketone body increasing effect of medium-chain fatty acid oil. Make three healthy adults ingest ketogenic formula or placebo food (a composition with the same composition as the ketogenic formula, and all lipids are long-chain fatty acid oils (excluding medium-chain fatty acid oils)), and measure blood ketones after ingestion body concentration, it was confirmed that the ketogenic formula was better than the placebo food to increase the concentration of ketone bodies in the blood ( Image 6 ). The ketogenic formula can increase ketone bodies in the ketogenic diet, but it has been proven that it is not only effective for animals but also for humans. In addition, it is preferable to use a medium-chain fatty acid as a lipid to obtain an effect of increasing ketone bodies.

[0260] In this example, a separate facility open inquiry test was conducted on 5 patients. Subject patients were selected according to the following criteria.

[0261] (adaptation benchma...

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Abstract

The invention provides new compositions or combinations thereof for the treatment of cancer. More specifically, the invention provides compositions or combinations thereof for cancer treatment including a high-fat diet. Specifically, the high-fat diet is characterized by having approximately 120 g / day or more, or approximately 70% or more of the total daily energy, from fat, based on a real weightof 50 kg. The diet is preferably a carbohydrate-restricted high-fat diet, and more preferably provided by a ketone formula and / or MCT oil. The dietary therapy by a high-fat diet of the present invention is provided along with surgical treatment, chemotherapy or radiation therapy, or combinations thereof.

Description

technical field [0001] The present invention relates to technical fields related to compositions or combinations for preventing or treating cancer. In more detail, the present invention relates to compositions or combinations for providing dietary therapy for cancer treatment. If further defined, it relates to the use of a high-fat diet, such as a low-sugar high-fat diet, in the treatment of advanced cancer. Background technique [0002] In recent years, early detection of resectable gastric cancer, colorectal cancer and other tumors has significantly improved the life prognosis of patients. However, pancreatic cancer, gallbladder cancer, lung cancer, etc. are mostly discovered in the late stage of cancer, and sometimes they are used at the same time. Chemotherapy and radiation therapy that damage QOL have not significantly improved the prognosis (National Cancer Surveillance Statistics 2000-2002 Survival Rate Report, National Cancer Research Center, China). [0003] In re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/22A61K31/7016A61P35/00A61P43/00
CPCA61K45/00A61K31/22A61K31/7016A23L33/30A23L33/115A61P35/00A23V2002/00A61K31/225A23V2200/308A23V2200/332A23V2200/3322
Inventor 萩原圭祐芦田欣也殿内秀和中村健太郎
Owner OSAKA UNIV
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