Lubiprostone solid dispersion and preparation method thereof
A technology of solid dispersion and lubiprostone, which is applied in the field of lubiprostone solid dispersion and its preparation, can solve the problems related to the undiscovered solid dispersion of lubiprostone, etc., and solve the problem of organic solvent residue , the effect of improving the dissolution rate
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Embodiment 1
[0018] Embodiment 1 lubiprostone solid dispersion and preparation method thereof
[0019] Put 8 mg of lubiprostone, 24,000 mg of poloxamer 188 and 240,000 mg of polyethylene glycol 4000 melted in a water bath at 50-60°C in an evaporating dish, add appropriate amount of distilled water and stir until lubiprostone and poloxamer 188 and polyethylene glycol 4000 were dissolved in water to form a clear solution, which was freeze-dried until the sample was completely dried, and packed into 1000 capsules.
Embodiment 2
[0020] Embodiment 2 lubiprostone solid dispersion and preparation method thereof
[0021] Put 24 mg of lubiprostone, 72,000 mg of poloxamer 188 and 720,000 mg of polyethylene glycol 4000 melted in a water bath at 50-60°C in an evaporating dish, add an appropriate amount of distilled water and stir until lubiprostone and poloxamer 188 and polyethylene glycol 4000 were dissolved in water to form a clear solution, which was freeze-dried until the sample was completely dried, and packed into 1000 capsules.
Embodiment 3
[0022] Embodiment 3 lubiprostone solid dispersion and preparation method thereof
[0023] Put 8 mg of lubiprostone and 240,000 mg of polyethylene glycol 4000 melted in a water bath at 50-60°C in an evaporating dish, add an appropriate amount of distilled water and stir until both lubiprostone and polyethylene glycol 4000 are dissolved in water and form a clear The solution was freeze-dried until the sample was completely dried, and packed into 1000 capsules.
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