Medical cold compress patch and preparation method thereof

A technology of cold compress and sodium hyaluronate, which is applied in the field of medicine, can solve the problems of infected wound parts, leakage of refrigerant, inconvenience in use, etc., and achieves the repair of damaged skin tissue, good biocompatibility, and lasting and uniform cooling. Effect

Inactive Publication Date: 2018-06-29
NANJING TZONE BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although ice pack cold compress physiotherapy has a remarkable therapeutic effect, it is restricted by the inherent characteristics of existing ice packs. There are still many defects and deficiencies in ice pack therapy: for example, when the ice pack freezes when it is filled with cold, the ice pack will solidify into lumps, and it is very difficult to target the ice pack in emergency use. It is difficult to fit completely, especially the joints or body curves; the ice pack needs to be filled with cold to use, and it needs to be frozen for a long time at low temperature, which is inconvenient to use; the ice pack is taken out of the refrigerator, and the temperature is relatively low. The patient will feel uncomfortable; there is basically no targeted treatment effect; the refrigerant in the ice pack may leak out and infect the wound site

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A medical cold compress containing hyaluronic acid, comprising the following components in mass percentage: sodium hyaluronate (0.1%), epidermal growth factor (0.1%), zinc-binding metallothionein (0.02%), aloe extract ( 3%), Vitamin E (1%), Glycerin (2%), Phenoxyethanol (0.3%), Ethylhexylglycerin (0.3%), Carbomer 940 (0.15%), Triethanolamine (0.08%), Make up to 100% with deionized water.

[0031] Among them, the molecular weight of high molecular weight sodium hyaluronate is 1.5×10 6 Da, the molecular weight of small molecular weight sodium hyaluronate is 5000Da.

[0032] The preparation method of above-mentioned medical cold compress is as follows:

[0033] (1) Mix sodium hyaluronate and carbomer with an appropriate amount of water, soak at room temperature, homogenize for 5 minutes, and stir at a speed of 300r / min for 30 minutes to fully swell and disperse evenly, as component one;

[0034] (2) Mix glycerin, vitamin E, phenoxyethanol, and ethylhexylglycerin, stir a...

Embodiment 2

[0040] A medical cold compress, comprising the following components by mass percentage: sodium hyaluronate (0.15%), epidermal growth factor (0.2%), zinc-binding metallothionein (0.04%), aloe extract (2%), vitamin E (3%), glycerin (4%), phenoxyethanol (0.2%), ethylhexylglycerin (0.3%), carbomer 940 (0.2%), triethanolamine (0.12%), deionized water supplement to 100%.

[0041] Among them, the molecular weight of high molecular weight hyaluronic acid is 1.6×10 6 Da, the molecular weight of small molecular weight sodium hyaluronate is 7000Da.

[0042] The preparation method of above-mentioned medical cold compress is as follows:

[0043](1) Mix sodium hyaluronate and carbomer with an appropriate amount of water, soak at room temperature, homogenize for 5 minutes, and stir at a speed of 300r / min for 30 minutes to fully swell and disperse evenly, as component one;

[0044] (2) Mix glycerin, vitamin E, phenoxyethanol, and ethylhexylglycerin, stir at 300r / min for 15min at room tempe...

Embodiment 3

[0050] A medical cold compress, comprising the following components by mass percentage: sodium hyaluronate (0.12%), epidermal growth factor (0.15%), zinc-binding metallothionein (0.08%), aloe extract (3%), vitamin E (4%), Glycerin (3%), Phenoxyethanol (0.2%), Ethylhexylglycerin (0.2%), Carbomer 940 (0.3%), Triethanolamine (0.2%), Deionized Water Complement to 100%.

[0051] Among them, the molecular weight of high molecular weight hyaluronic acid is 1.7×10 6 Da, the molecular weight of small molecular weight sodium hyaluronate is 9000Da.

[0052] The preparation method of above-mentioned medical cold compress is as follows:

[0053] (1) Mix sodium hyaluronate and carbomer with an appropriate amount of water, soak at room temperature, homogenize for 5 minutes, and stir at a speed of 300r / min for 30 minutes to fully swell and disperse evenly, as component one;

[0054] (2) Mix glycerin, vitamin E, phenoxyethanol, and ethylhexylglycerin, stir at 300r / min for 15min at room temp...

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Abstract

The invention relates to a medical cold compress patch and a preparation method thereof. The medical cold compress patch is prepared from the following components in percentage by mass: 0.05-0.2% of sodium hyaluronate, 0.002-0.2% of epidermal growth factor, 0.005-0.1% of zinc-binding metallothionein, 3-6% of aloe extract, 1-4% of vitamin E, 1-5% of glycerin, 0.2-0.4% of phenoxyethanol, 0.2-0.4% ofethylhexylglycerin, 0.1-0.3% of Carbomer 940, 0.08-0.2% of triethanolamine and the balance of deionized water based on 100%. The medical cold compress patch has the following advantages: (1) the cooling is uniform, lasting and mild; (2) the biocompatibility is high, and stimulation or toxic or side effects are avoided; (3) at the time of cold compress, an effect of repairing the damaged skin tissues is realized; the medical cold compress patch is safe and convenient to use; (4) unwell symptoms of closed soft tissues are relieved, including soft tissue sprain, contusion, cold compress paint after laser cosmetic surgery, eye fatigue, and the like.

Description

technical field [0001] The invention relates to a medical cold compress containing hyaluronic acid and a preparation method thereof, belonging to the field of medicine. Specifically, it is a cold compress product used for analgesia of closed soft tissue and local skin after laser surgery, and cold compress physiotherapy and its preparation process. Background technique [0002] Due to various reasons (such as acute soft tissue injury) and local skin due to laser surgery or cryotherapy, cold compress physiotherapy is usually required to reduce local skin temperature, reduce swelling, stop bleeding, and relieve pain, so as to achieve relief or treatment of the disease intended purpose. Cold compress is a kind of cold compress physiotherapy. Traditional cold compress methods include using ice water, ice cubes, alcohol, etc. Through these methods of cold compress, the cooling time is short, and it is inconvenient to use and consumes a lot. Simultaneously this type of product i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K9/06A61K47/10A61P29/00A61P27/02A61F7/02A61K38/16A61K36/068A61K36/896A61K36/886A61K31/728
CPCA61F7/02A61F2007/0219A61F2007/022A61F2007/0263A61K9/06A61K31/728A61K36/068A61K36/886A61K36/896A61K38/168A61K38/1808A61K47/10A61K2300/00
Inventor 金玉
Owner NANJING TZONE BIOLOGICAL SCI & TECH
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