Medical cold compress patch and preparation method thereof
A technology of cold compress and sodium hyaluronate, which is applied in the field of medicine, can solve the problems of infected wound parts, leakage of refrigerant, inconvenience in use, etc., and achieves the repair of damaged skin tissue, good biocompatibility, and lasting and uniform cooling. Effect
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Embodiment 1
[0030] A medical cold compress containing hyaluronic acid, comprising the following components in mass percentage: sodium hyaluronate (0.1%), epidermal growth factor (0.1%), zinc-binding metallothionein (0.02%), aloe extract ( 3%), Vitamin E (1%), Glycerin (2%), Phenoxyethanol (0.3%), Ethylhexylglycerin (0.3%), Carbomer 940 (0.15%), Triethanolamine (0.08%), Make up to 100% with deionized water.
[0031] Among them, the molecular weight of high molecular weight sodium hyaluronate is 1.5×10 6 Da, the molecular weight of small molecular weight sodium hyaluronate is 5000Da.
[0032] The preparation method of above-mentioned medical cold compress is as follows:
[0033] (1) Mix sodium hyaluronate and carbomer with an appropriate amount of water, soak at room temperature, homogenize for 5 minutes, and stir at a speed of 300r / min for 30 minutes to fully swell and disperse evenly, as component one;
[0034] (2) Mix glycerin, vitamin E, phenoxyethanol, and ethylhexylglycerin, stir a...
Embodiment 2
[0040] A medical cold compress, comprising the following components by mass percentage: sodium hyaluronate (0.15%), epidermal growth factor (0.2%), zinc-binding metallothionein (0.04%), aloe extract (2%), vitamin E (3%), glycerin (4%), phenoxyethanol (0.2%), ethylhexylglycerin (0.3%), carbomer 940 (0.2%), triethanolamine (0.12%), deionized water supplement to 100%.
[0041] Among them, the molecular weight of high molecular weight hyaluronic acid is 1.6×10 6 Da, the molecular weight of small molecular weight sodium hyaluronate is 7000Da.
[0042] The preparation method of above-mentioned medical cold compress is as follows:
[0043](1) Mix sodium hyaluronate and carbomer with an appropriate amount of water, soak at room temperature, homogenize for 5 minutes, and stir at a speed of 300r / min for 30 minutes to fully swell and disperse evenly, as component one;
[0044] (2) Mix glycerin, vitamin E, phenoxyethanol, and ethylhexylglycerin, stir at 300r / min for 15min at room tempe...
Embodiment 3
[0050] A medical cold compress, comprising the following components by mass percentage: sodium hyaluronate (0.12%), epidermal growth factor (0.15%), zinc-binding metallothionein (0.08%), aloe extract (3%), vitamin E (4%), Glycerin (3%), Phenoxyethanol (0.2%), Ethylhexylglycerin (0.2%), Carbomer 940 (0.3%), Triethanolamine (0.2%), Deionized Water Complement to 100%.
[0051] Among them, the molecular weight of high molecular weight hyaluronic acid is 1.7×10 6 Da, the molecular weight of small molecular weight sodium hyaluronate is 9000Da.
[0052] The preparation method of above-mentioned medical cold compress is as follows:
[0053] (1) Mix sodium hyaluronate and carbomer with an appropriate amount of water, soak at room temperature, homogenize for 5 minutes, and stir at a speed of 300r / min for 30 minutes to fully swell and disperse evenly, as component one;
[0054] (2) Mix glycerin, vitamin E, phenoxyethanol, and ethylhexylglycerin, stir at 300r / min for 15min at room temp...
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