Medicinal composition for treating atherosclerosis

A technology of atherosclerosis and composition, applied in the field of pharmaceutical composition for treating atherosclerosis, preventing and/or treating atherosclerosis

Active Publication Date: 2018-06-29
THE SEVENTH AFFILIATED HOSPITAL SUN YAT SEN UNIV SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, there is no report on the combined use of arginine and platelet aggrega

Method used

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Examples

Experimental program
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Embodiment Construction

[0025] The preferred implementation of the present invention is described in detail below, so that the advantages and features of the present invention can be more easily understood by those skilled in the art.

[0026] Therapeutic effect of drugs on hyperlipidemia model in rats fed with high-fat diet

[0027] 1.1 Experimental animals

[0028] 180 Wistar rats were randomly divided into 18 groups according to body weight, 10 rats in each group, respectively control group, hyperlipidemia group, arginine treatment group, aspirin treatment group, clopidogrel treatment group, sargrelate treatment group group, arginine + aspirin treatment group (4 matching groups); arginine + clopidogrel treatment group (4 matching groups), arginine + sagrelate treatment group (4 matching groups) . Control group: raise 90 days with common feed, common drinking water; Except control group, other each groups all raises 90 days with high-fat feed, common drinking water. The high-fat feed added 2% ch...

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PUM

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Abstract

The invention relates to a medicinal composition for treating atherosclerosis, and application of the medicinal composition. The medicinal composition comprises L-arginine, a platelet aggregation inhibitor and a pharmaceutically acceptable salt or ester thereof, and one or more pharmaceutically acceptable carriers, wherein the platelet aggregation inhibitor comprises aspirin, clopidogrel, sarpogrelate and pharmaceutically acceptable salts or esters thereof. The medicinal composition can be used for preventing and/or treating atherosclerosis, and is capable of reducing morbidity and mortality rates of atherosclerosis.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition for treating atherosclerosis and its application in preventing and / or treating atherosclerosis. Background technique [0002] Cardiovascular disease is one of the major diseases that endanger human health at present, and its high morbidity, disability and mortality have brought heavy burdens to the society and residents. Its most basic pathological process is atherosclerosis. [0003] The causes of atherosclerosis include accumulation of blood lipids, endothelial cell damage and inflammatory response. Impairment of endothelial function is the initiating link of atherosclerosis, which can reflect the severity of atherosclerosis development. Risk factors for atherosclerosis such as hyperlipidemia, hypertension, diabetes, smoking, and hyperuricemia first lead to impaired endothelial function, which is represented by endothelium-dependent vasodilation dysfunction....

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/198A61K31/616A61K31/4365A61K31/225A61P9/10
CPCA61K31/198A61K31/225A61K31/4365A61K31/616A61K45/06A61K2300/00
Inventor 郎济禄孙贤
Owner THE SEVENTH AFFILIATED HOSPITAL SUN YAT SEN UNIV SHENZHEN
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