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Sterile liquid change device for cell thawing and method for cell thawing liquid change by sterile liquid change device

A cell and cleaning solution technology, applied in the field of medical devices, can solve the problems of limiting the time and effective area of ​​stem cell transportation in the resuscitation state, and restricting the development of the clinical application industry of stem cells, so as to achieve the effect of facilitating operation and application of force and prolonging service life.

Pending Publication Date: 2018-07-13
博品(上海)生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Current technical defects: On the one hand, because hospitals usually do not have cell aseptic operation rooms, if they are transported in conventional cryopreservation bottles, there will be risks to the health and safety of stem cell therapy; on the other hand, if cell resuscitation is used to complete in the company, After being transported to the hospital, living cells in the resuscitated state have extremely high requirements on external environmental conditions such as liquid temperature, carbon dioxide concentration, and vibration stability, so although a lot of manpower and material resources are often spent during transportation, it is still unavoidable. cell loss
These two aspects limit the transportation time and effective area of ​​the stem cells in the recovery state, and ultimately restrict the development of the stem cell clinical application industry.

Method used

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  • Sterile liquid change device for cell thawing and method for cell thawing liquid change by sterile liquid change device
  • Sterile liquid change device for cell thawing and method for cell thawing liquid change by sterile liquid change device
  • Sterile liquid change device for cell thawing and method for cell thawing liquid change by sterile liquid change device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] See attached Figure 1-4 :

[0042] A sterile liquid exchange device for cell resuscitation, including a base 1, a bracket 2, a liquid exchange mechanism, and a resuscitation bottle 3;

[0043] The resuscitation bottle has a circular structure, including the upper bottle 4 and the lower bottle 5; the thread 6 is set outside the lower port of the upper bottle, and the thread is set inside the upper port of the lower bottle (not shown in the figure), and the upper bottle and the lower bottle are connected by threads; the upper end of the upper bottle A rubber sealing plug 7 is provided, and a cell filter 8 is provided at the lower end; the upper end of the lower bottle is opened, and a sealing piston 9 is provided at the lower end;

[0044] The base is provided with a fixed rod 10 and a through hole 11. The fixed rod is an L-shaped structure, one side is connected to the base for rotation, and the other side is provided with an opening 12. The fixed rod is connected to t...

Embodiment 2

[0048] Aseptic liquid exchange device for cell recovery, including base, bracket, liquid exchange mechanism, and recovery bottle;

[0049] See attached Figure 5-8 , the resuscitation bottle is a circular structure, including the upper bottle 4 and the lower bottle 5; the thread 6 is set outside the lower port of the upper bottle, and the thread is set inside the upper port of the lower bottle (not marked in the figure), and the upper bottle and the lower bottle are connected by threads; the upper bottle The upper end is provided with a rubber sealing plug 7, and the lower end is provided with a cell strainer 8; the upper end of the lower bottle is open, and the lower end is provided with a sealing piston 9, and the outer side of the upper port of the lower bottle is provided with a peripheral groove 23, and the inner wall of the lower port of the upper bottle is provided with a circle of card slots 24. The cell strainer is stuck in the slot, the depth of the slot is 0.5 mm, t...

Embodiment 3

[0053] Aseptic liquid exchange device for cell recovery, including base, bracket, liquid exchange mechanism, and recovery bottle;

[0054] The resuscitation bottle has a circular structure, including an upper bottle and a lower bottle; threads are provided on the outside of the lower port of the upper bottle, threads are provided on the inside of the upper port of the lower bottle, and the upper bottle and the lower bottle are connected by threads; the upper end of the upper bottle is provided with a rubber sealing plug, and the lower end is provided with a Cell strainer; the upper end of the lower bottle is opened, and the lower end is provided with a sealing piston. The bottom of the sealing piston is installed on the piston rod of the cylinder according to the existing method, and the movement of the sealing piston can be controlled by the cylinder. There is a peripheral groove outside the upper port of the lower bottle. There is a circle of slots on the inner wall of the lo...

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Abstract

The invention discloses a sterile liquid change device for cell thawing and a method for cell thawing liquid change by the sterile liquid change device. The device comprises a base, a supporting frame, a liquid change mechanism and a thawing bottle, the thawing bottle comprises an upper bottle and a lower bottle, and the upper bottle and the lower bottle are in threaded connection. The upper end of the upper bottle is provided with a rubber seal plug while the lower end of the upper bottle is provided with a cell filter screen, and the upper end of the lower bottle is open while the lower endof the lower bottle is provided with a seal piston. By innovative design of the upper and lower bottle structures and the cell filter screen, cryopreservation, thawing, cleaning and replacement in thebottle can be realized. By adoption of the sterile liquid change device, low-temperature long-time remote stable transport can be realized, sterile convenience liquid change in hospitals is realized,and accordingly stem cell thawing and liquid change in a natural environment are realized prior to application to injection, and problems of failure in thawing in hospitals, requirement of a strict sterile environment for operation and the like in the prior art are solved.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a medical stem cell aseptic liquid exchange device in an open environment and a method for cell resuscitation and liquid exchange using the device. Background technique [0002] Stem cells are primitive cells with self-replication and multi-directional differentiation potential in the human body. Under certain conditions, they can be induced to differentiate into more than 220 functional cells such as nerve cells, liver cells, and cardiomyocytes that constitute the human body. They are the origin cells of our body. It is the original cell that forms various tissues and organs in the human body. The aging and pathological changes of the body are caused by the decline in the quantity and quality of stem cells. Therefore, stem cell therapy has been widely used clinically, and it is the most basic raw material and means for treating various intractable diseases in the 21st c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/34C12M1/24C12M1/00
CPCC12M23/08C12M41/12
Inventor 徐俊祁旻龙黄昆镝朱良周小龙汪光明
Owner 博品(上海)生物医药科技有限公司
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