Novel activating agent for immune cell amplification and preparation method thereof

Abstract

The invention discloses a novel activating agent for immune cell amplification and a preparation method thereof. The novel activating agent is prepared from the following ingredients in parts by weight: 20 to 26 percent of biological conductive nanometer fiber, 1 to 3 percent of power generation cells, 3 to 4 percent of gel mixed solution, 9 to 11 percent of composite agonists, 12 to 14 percent ofartificial cell membranes, 0.3 to 0.8 percent of cell membrane activators, 8 to 10 percent of specific antibodies and the balance of culture base solution. A great part of biological conductive nanometer fiber is used for performing loading on the composite agonists; then, the artificial cell membranes are used for coating; finally, after the treatment and activation by cell membrane activating materials, a specific antibody is combined; the power generation cells and the gel mixed solution are planted on the other small part of biological conductive nanometer fiber; then, the two parts of biological conductive nanometer fiber are put into a culture base solution to form the novel activating agent for immune cell amplification. Generally, the novel activating agent can improve the in vitro proliferation rate of immune cells by 10 to 15 times.

Description

technical field [0001] The invention belongs to the fields of bioengineering and biomedicine, and in particular relates to a novel activator for immune cell expansion and a preparation method thereof. Background technique [0002] Immune cell is a common name for white blood cells, including lymphocytes and various phagocytes, etc., and specifically refers to lymphocytes that can recognize antigens and generate specific immune responses. Lymphocytes are the basic components of the immune system and are widely distributed in the body. Mainly T lymphocytes and B lymphocytes are activated by antigen stimulation, divide and proliferate, and produce specific immune responses. In addition to T lymphocytes and B lymphocytes, there are four types of K lymphocytes and NK lymphocytes. T lymphocytes are a multifunctional cell population. In addition to lymphocytes, cells involved in the immune response include plasma cells, granulocytes, mast cells, antigen-presenting cells, and cell...

AI Technical Summary

Problems solved by technology

[0004] However, the effect of the activator for immune cell expansion in the prior art is not ideal, the number of cultivated and expanded immune cells is low and the quality is poor, and the components of the used activator are imported back into the patient's body along with the immune cells, which is likely to cause adverse reactions

Images