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A method for establishing hplc fingerprint of Cyclocarya granules

A fingerprint spectrum and a technology for establishing a method are applied in the field of establishing the HPLC fingerprint spectrum of Qingqianliu granules to achieve the effects of strong operability, ensuring safety and effectiveness, and good repeatability.

Active Publication Date: 2021-02-23
广西中道医药科技有限公司
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  • Application Information

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Problems solved by technology

However, there is no literature report on the research on the HPLC fingerprints of Cyclocarya granules. The present invention establishes the HPLC fingerprints of Cyclocarya granules through high-performance liquid chromatography, and compares them with the Chinese medicine chromatographic fingerprint similarity evaluation system. It is of great significance to analyze it to provide a basis for distinguishing other varieties and quality control of Cyclocarya paliurus

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  • A method for establishing hplc fingerprint of Cyclocarya granules
  • A method for establishing hplc fingerprint of Cyclocarya granules
  • A method for establishing hplc fingerprint of Cyclocarya granules

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Embodiment 1

[0021] Instrument: Agilent high performance liquid chromatography.

[0022] Medicinal materials: Cyanocarya granules provided by Guangxi Zhuangyao Pharmaceutical Engineering Technology Research Center; Cyclocarya caraliac as a reference drug provided by Guangxi Alili Health Science and Technology Co., Ltd.

[0023] Reagents: mobile phase A, acetonitrile is chromatographically pure, water is ultrapure water, and other reagents are analytically pure.

[0024] Preparation of the test solution: Accurately weigh 1.0g of Cyclocarya paliurus granules, place in a round-bottomed flask, add 50mL of petroleum ether, reflux for 2-3h, discard the petroleum ether, evaporate the dregs, add 20mL of acetonitrile precisely, weigh Determine the mass, ultrasonically dissolve for 30 minutes, make up the lost mass with acetonitrile, shake well, filter through a microporous membrane, and take the subsequent filtrate to obtain the test solution.

[0025] Preparation of the reference solution: Take C...

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Abstract

The present invention proposes a method for establishing the HPLC fingerprint of Cyclocarya granules, including the preparation of the test sample, the determination of chromatographic conditions, and the use of a high-performance liquid chromatograph for measurement to obtain the HPLC fingerprint of Cyclocarya granules, which is comprehensive and accurate The chemical information of Cyclocarya granules is expressed. The fingerprint has the characteristics of good separation and peak shape of common peaks, good repeatability, and strong operability, which can effectively control the quality of Cyclocarya granules.

Description

technical field [0001] The invention relates to the field of quality control of traditional Chinese medicine preparations, in particular to a method for establishing HPLC fingerprints of Cyanocarya granules. Background technique [0002] Cyclocarya paliurus is a plant of the Juglandaceae Cyclocarya genus. According to the records of "Chinese Materia Medica", it has the effects of dispelling wind, reducing inflammation and pain, killing insects and relieving itching. Folks mostly use its leaves as medicinal parts, which have a long history of use. Modern studies have shown that Cyclocarya paliurus leaves have the functions of promoting body fluid and quenching thirst, lowering blood sugar, lowering blood pressure, and prolonging life. It can be used to treat diabetes, high blood pressure, and neurasthenia. The existing literature reports that the content of quercetin and kaempferol in Cyclocarya paliurus is used as the quality control standard of medicinal materials, but bes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 赵立春钟余特王雪于培良李俊秀
Owner 广西中道医药科技有限公司
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