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A kind of preparation method of grass coral extract liposome hydrogel

A technology of hydrogel and coral, which is applied in the field of preparation of liposome hydrogel of grass coral extract, to achieve the effect of improving user experience, significant effect and long treatment cycle

Active Publication Date: 2021-07-02
广西呈鸣生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the use of liposome formulations of drugs as transdermal formulations has been reported

Method used

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  • A kind of preparation method of grass coral extract liposome hydrogel
  • A kind of preparation method of grass coral extract liposome hydrogel
  • A kind of preparation method of grass coral extract liposome hydrogel

Examples

Experimental program
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Embodiment 1

[0024] According to one aspect of the present invention, this embodiment provides a kind of preparation method of liposome hydrogel of Herba Corona extract, comprising the following steps:

[0025] (1), preparation of coral coral extract liposomes: take 5g of lecithin, 2.5g of cholesterol, 3g of laurocaprolactone and 0.5g of coral coral extract and dissolve them in 120mL chloroform solution and put them under 10°C and a pressure of -0.065 Rotate slowly under the condition of MPa. After the chloroform is completely evaporated, add a sodium alginate solution with a concentration of 1% and a volume of 80mL for mixing, then place it on a shaker and shake it for 1h, and put it into a low-temperature ultrasonic instrument for ultrasonic dispersion for 1min. Until the mixed solution becomes a clear and transparent light yellow lipid colloid solution;

[0026] (2) Preparation of hydrogel: Stir continuously for 25min at a temperature of 35°C, at a stirring speed of 20r / min, and slowly ...

Embodiment 2

[0028] According to one aspect of the present invention, this embodiment provides a kind of preparation method of liposome hydrogel of Herba Corona extract, comprising the following steps:

[0029] (1), preparation of coral coral extract liposomes: take 15g of lecithin, 5g of cholesterol, 1g of laurocaprolactone and 2g of coral coral extract and dissolve them in 150mL chloroform solution and under 5°C and pressure of -0.09MPa After the chloroform is completely evaporated, add a sodium alginate solution with a concentration of 1% and a volume of 100mL for mixing, then place it on a shaker and shake it for 2 hours, then put it in a low-temperature ultrasonic instrument for ultrasonic dispersion for 3 minutes until mixed The solution becomes a clear and transparent light yellow lipid colloid solution;

[0030] (2) Preparation of hydrogel: Stir continuously for 45min at a temperature below 45°C, at a stirring speed of 50r / min, and at the same time slowly add a concentration of 0.1...

Embodiment 3

[0032] According to one aspect of the present invention, this embodiment provides a kind of preparation method of liposome hydrogel of Herba Corona extract, comprising the following steps:

[0033](1), preparation of coral coral extract liposomes: take 12g of lecithin, 4g of cholesterol, 2.8g of laurocaprolactone and 1.2g of coral coral extract and dissolve them in 130mL chloroform solution and put them under 10°C and a pressure of -0.075 Rotate slowly under the condition of MPa. After the chloroform is completely evaporated, add a sodium alginate solution with a concentration of 1% and a volume of 100mL for mixing, then place it on a shaker and shake it for 1.5h, then put it into a low-temperature ultrasonic instrument for ultrasonic dispersion for 2min , until the mixed solution becomes a clear and transparent light yellow lipid colloid solution;

[0034] (2) Preparation of hydrogel: Stir continuously for 30min at a temperature of 40°C, at a stirring speed of 35r / min, and at...

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Abstract

The invention discloses a method for preparing a liposome hydrogel of a coral coral extract. Firstly, lecithin, cholesterol, laurocapram and a coral coral extract are dissolved in 100mL-150mL chloroform solution and heated at a temperature below 10°C. Rotate the evaporation slowly under the condition of ‑0.065MPa~‑0.09MPa. After the chloroform is completely evaporated, add the sodium salt solution for mixing, then place it on a shaker and shake it for 1h~2h, then put it into a low-temperature ultrasonic instrument for ultrasonic dispersion for 1min~ 3min, until the mixed solution becomes a clear and transparent lipid colloid solution; then keep stirring at a temperature below 45°C, and at the same time slowly add calcium salt solution dropwise to the above-mentioned clear and transparent lipid colloid solution, dropwise within 30min After the addition is completed, continue to stir slowly evenly, then transfer to a packaging container for packaging and molding, then seal it with a clean sealing film, and place it in a frozen environment for sealed storage, that is, the required liposome hydrogel of the grass coral extract is prepared. glue. The paper body hydrogel of the invention has a remarkable effect on treating pharyngitis.

Description

technical field [0001] The invention belongs to the technical field of health care and medicine, and in particular relates to a method for preparing a liposome hydrogel of a coral coral extract. Background technique [0002] As a type of preparation, liposomes can improve the therapeutic effect of drugs and reduce the adverse reactions of some drugs. For the improvement of formulations, liposomes with targeting properties can be prepared to further reduce the impact of drugs on healthy cells. However, since the structure of the liposome is easily damaged by the influence of the external environment, and the phospholipids in the liposome are also easily oxidized to cause liposome rupture, these are difficult to meet the stability requirements of pharmaceutical preparations, which also Make the application of liquid liposome be severely restricted. And though freeze-dried liposome can overcome the shortcoming of liquid liposome aspect stability. However, the price of freeze-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K9/06A61K36/185A61P11/04
CPCA61K9/06A61K9/127A61K36/185A61K47/28A61P11/04
Inventor 覃淑芬覃淑宁
Owner 广西呈鸣生物科技有限公司
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